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1.5.1.39: FMN reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about FMN reductase [NAD(P)H], go to the full flat file.

Reaction

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FMNH2
+
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NAD(P)+
=
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FMN
+
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NAD(P)H
+
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H+

Synonyms

ChuY, EC 1.5.1.29, EC 1.6.8.1, flavin mononucleotide reductase, FMN reductase, fre, FRG, H2O-forming FOR, LrFOR, NAD(P)H-flavin reductase, NAD(P)H:FMN-oxidoreductase, NADH: FMN oxidoreductase, NADPH-dependent FMN reductase, NfoR, non-specific NAD(P)H-FMN reductase, pden_5119, Red, SsuE, two-component FMN-dependent monooxygenase, water forming NADH: FMN oxidoreductase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                EC 1.5.1.391.5.1.39 FMN reductase [NAD(P)H]

Expression

Expression on EC 1.5.1.39 - FMN reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.5.1.39

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
Pden_5119 transcript rises in response to oxidative stressors, respiratory chain inhibitors and terminal oxidase downregulation. The enzyme is induced by 0.05 mM methyl viologen, 0.5 mM diamide, and 0.11 mM t-butyl hydroperoxide. Expression of the Pden_5119 gene is oxidative stress inducible. Strains Pd9233 and Pd9311 contain aa3-type or cbb3-type cytochrome c oxidase, respectively, as the only terminal oxidase of the respiratory electron transfer chain, the flux capacity through terminal oxidase is reduced in strain Pd9311 compared to strain Pd9233 or wild-type strain, manifested by the much lower specific activity of TMPD oxidase found in the cytoplasmic membrane fraction. The pden_5119 transcript in Pd9311 cells but not in Pd9233 cells is elevated similarly as observed in the wild-type strain growing in the presence of electron transfer inhibitors. Downregulation of terminal oxidase thus indeed results in a similar outcome as chemical inhibition