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1.5.1.39: FMN reductase [NAD(P)H]

This is an abbreviated version!
For detailed information about FMN reductase [NAD(P)H], go to the full flat file.

Reaction

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FMNH2
+
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NAD(P)+
=
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FMN
+
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NAD(P)H
+
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H+

Synonyms

ChuY, EC 1.5.1.29, EC 1.6.8.1, flavin mononucleotide reductase, FMN reductase, fre, FRG, H2O-forming FOR, LrFOR, NAD(P)H-flavin reductase, NAD(P)H:FMN-oxidoreductase, NADH: FMN oxidoreductase, NADPH-dependent FMN reductase, NfoR, non-specific NAD(P)H-FMN reductase, pden_5119, Red, SsuE, two-component FMN-dependent monooxygenase, water forming NADH: FMN oxidoreductase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                EC 1.5.1.391.5.1.39 FMN reductase [NAD(P)H]

Engineering

Engineering on EC 1.5.1.39 - FMN reductase [NAD(P)H]

for references in articles please use BRENDA:EC1.5.1.39

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Y118A
site-directed mutagenesis, the structure of the Y118A SsuE Pi-helix is converted to an alpha-helix, similar to the FMN-bound members of the NADPH:FMN reductase family. Although the Pi-helix is altered, the FMN binding region remains unchanged. The mutant forms dimers in contrast to the wild-type
Y118H
site-directed mutagenesis, inactive mutant
G298A
-
site-directed mutagenesis, inactive mutant
H170A
-
site-directed mutagenesis, inactive mutant
H319A
-
site-directed mutagenesis, inactive mutant
M28A
-
site-directed mutagenesis, inactive mutant
N173A
-
site-directed mutagenesis, the mutant shows 66% reduced activity compared to wild-type enzyme
T29A
-
site-directed mutagenesis, the mutant shows 2.91fold increased activity compared to the wild-type enzyme
T29D
-
site-directed mutagenesis, the mutant shows 3.9fold increased activity compared to the wild-type enzyme
T29G
-
site-directed mutagenesis, the mutant shows 3.7fold increased activity compared to the wild-type enzyme
T29N
-
site-directed mutagenesis, the mutant shows 2.2fold increased activity compared to the wild-type enzyme
T29R
-
site-directed mutagenesis, the mutant shows 90% reduced activity compared to wild-type enzyme
T29Y
-
site-directed mutagenesis, the mutant shows 40% reduced activity compared to wild-type enzyme
Y341A
-
site-directed mutagenesis, inactive mutant
G298A
-
site-directed mutagenesis, inactive mutant
-
H170A
-
site-directed mutagenesis, inactive mutant
-
H319A
-
site-directed mutagenesis, inactive mutant
-
N173A
-
site-directed mutagenesis, the mutant shows 66% reduced activity compared to wild-type enzyme
-
additional information