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1.5.1.36: flavin reductase (NADH)

This is an abbreviated version!
For detailed information about flavin reductase (NADH), go to the full flat file.

Word Map on EC 1.5.1.36

Reaction

reduced flavin
+
NAD+
=
flavin
+
NADH
+
H+

Synonyms

AbeF, BaiH, BorF, C1-HpaH, DszD, FAD reductase, FerA, flavin mononucleotide reductase, flavin reductase, flavin:NADH oxidoreductase, FMN reductase, Frd188, frd2, fre, HpaC, LJ0548, LJ0549, LJ_0548, LJ_0549, LuxG, More, NAD(P)H-dependent H2O2-forming flavin reductase, NAD(P)H-flavin oxidoreductase, NAD(P)H:flavin oxidoreductase, NAD(P)H:flavin-oxidoreductase, NADH-dependent flavin reductase, NADH-flavin oxidoreductase, NADH: flavin oxidoreductase, NADH: flavinoxidore ductase/NADH oxidase, NADH:flavin oxidoreductase, NADH:FMN oxidoreductase, nfr1, nfr2, NOX, Pden2689, SMOB-ADP1

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.36 flavin reductase (NADH)

Inhibitors

Inhibitors on EC 1.5.1.36 - flavin reductase (NADH)

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
Acriflavine
Ag+
-
strong inhibition at 1 mM Ag+
AMP
mixed noncompetitive versus FMN, and competitive versus NADH
Cu2+
-
strong inhibition at 1 mM Cu2+
CuCl2
Fe2+
complete inactivation at 0.1 mM, 38% activity remains in presence of 10 mM EDTA
Hg2+
-
strong inhibition at 1 mM Hg2+
HgCl2
HpaB
-
presence and binding of HpaB reduced the enzyme activity of HpaC due to stabilization and reduced oxidation by O2 of FADH2
-
iodoacetate
1.0 mM, 9% inhibition
lumichrome
an FMN analogue completely lacking the ribityl side chain, competitive versus FMN, and mixed noncompetitive versus NADH
MarR
auto-inhibition by the C-terminal MarR domain, which might arise from steric hindrance
-
N-bromosuccinimide
N-ethylmaleimide
p-chloromercuriphenyl sulfonic acid
0.2 mM, 95% inhibition
p-chloromercuriphenylsulfonic acid
-
styrene oxide
slightly activating at 0.1 mM, inhibitory at 0.2 mM
ZnCl2
additional information
-