1.5.1.34: 6,7-dihydropteridine reductase
This is an abbreviated version!
For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.
Word Map on EC 1.5.1.34
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1.5.1.34
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tetrahydrobiopterin
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hydroxylase
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bh4
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hyperphenylalaninemia
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neurotransmitter
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phenylketonuria
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biopterin
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pterins
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dopamine
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quinonoid
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sepiapterin
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1.6.99.7
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cyclohydrolase
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6-pyruvoyl-tetrahydropterin
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5-hydroxytryptophan
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tetrahydropterin
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dihydrobiopterin
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l-dopa
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ptp
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folinic
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nadh-specific
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homovanillic
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pterin-4a-carbinolamine
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guthrie
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6-pyruvoyl
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dihydropterins
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gtpch
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medicine
- 1.5.1.34
- tetrahydrobiopterin
- hydroxylase
- bh4
- hyperphenylalaninemia
-
neurotransmitter
- phenylketonuria
- biopterin
- pterins
- dopamine
-
quinonoid
- sepiapterin
-
1.6.99.7
-
cyclohydrolase
- 6-pyruvoyl-tetrahydropterin
- 5-hydroxytryptophan
- tetrahydropterin
- dihydrobiopterin
- l-dopa
- ptp
-
folinic
-
nadh-specific
-
homovanillic
-
pterin-4a-carbinolamine
-
guthrie
-
6-pyruvoyl
- dihydropterins
- gtpch
- medicine
Reaction
Synonyms
7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)
ECTree
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Reference
Reference on EC 1.5.1.34 - 6,7-dihydropteridine reductase
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Kaufman, S.
Dihydropteridine reductase from sheep liver
Methods Enzymol.
142
97-103
1987
Ovis aries
Hasegawa, H.; Nakanishi, N.
Dihydropteridine reductase from bovine liver
Methods Enzymol.
142
103-110
1987
Bos taurus
Hasegawa, H.; Nakanishi, N.
NADPH-specific dihydropteridine reductase from bovine liver
Methods Enzymol.
142
111-116
1987
Bos taurus
Firgaira, F.A.; Cotton, R.G.H.; Jennings, I.; Danks, D.M.
Use of naphthoquinone adsorbent for the isolation of human dihydropteridine reductase
Methods Enzymol.
142
116-126
1987
Homo sapiens
Scrimgeour, K.G.; Cheema-Dhadli, S.
Dihydropteridine reductase from sheep brain
Methods Enzymol.
142
127-132
1987
Ovis aries
Williams, C.D.; Dickens, G.; Letendre, C.H.; Guroff, G.; Haines, C.; Shiota, T.
Isolation and characterization of dihydropteridine reductase from Pseudomonas species
J. Bacteriol.
127
1197-1207
1976
Pseudomonas sp.
Lockyer, J.; Cook, R.G.; Milstein, S.; Kaufman, S.; Woo, S.L.C.; Ledley, F.D.
Structure and expression of human dihydropteridine reductase
Proc. Natl. Acad. Sci. USA
84
3329-3333
1987
Ovis aries, Homo sapiens
Matthews, D.A.; Varughese, K.I.; Skinner, M.; Xuong, N.H.; Hoch, J.; Trach, K.; Schneider, M.; Bray, T.; Whiteley, J.M.
Role of aspartate-37 in determining cofactor specificity and binding in rat liver dihydropteridine reductase
Arch. Biochem. Biophys.
287
234-239
1991
Rattus norvegicus
Armarego, W.L.F.; Cotton, G.H.; Dahl, H.H.M.; Dixon, N.E.
High-level expression of human dihydropteridine reductase (EC 1.6.99.7), without N-terminal amino acid protection, in Escherichia coli
Biochem. J.
261
265-268
1989
Homo sapiens
Shahbaz, M.; Hoch, J.A.; Trach, A.; Hural, J.A.; Webber, S.; Whiteley, J.M.
Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase
J. Biol. Chem.
262
16412-16416
1987
Rattus norvegicus
Kwan, S.W.; Shen, R.S.; Abell, C.W.
An enzyme immunoassay for the quantitation of dihydropteridine reductase
Anal. Biochem.
164
391-396
1987
Rattus norvegicus
Matthews, D.A.; Webber, S.; Whiteley, J.M.
Preliminary x-ray diffraction characterization of crystalline rat liver dihydropteridine reductase
J. Biol. Chem.
261
3891-3893
1986
Rattus norvegicus
Randles, D.
Temperature dependence of dihydropteridine reductase activity
Eur. J. Biochem.
155
301-304
1986
Homo sapiens
Hasegawa, H.
Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH
J. Biochem.
81
169-177
1977
Bos taurus
Webber, S.; Whiteley, J.M.
Pyridine nucleotide interaction with rat liver dihydropteridine reductase
J. Biol. Chem.
253
6724-6729
1978
Rattus norvegicus
Purdy, S.E.; Blair, J.A.; Barford, P.A.
Inhibition of dihydropteridine reductase by dopamine
Biochem. J.
195
769-771
1981
Rattus norvegicus
Gould, K.G.; Engel, P.C.
Rat liver dihydropteridine reductase inhibition
Biochem. Soc. Trans.
8
565-566
1980
Rattus norvegicus
Firgaira, F.A.; Choo, K.H.; Cotton, R.G.H.; Danks, D.M.
Molecular and immunological comparison of human dihydropteridine reductase in liver, cultured fibroblasts and continuous lymphoid cells
Biochem. J.
197
45-53
1981
Homo sapiens
Webber, S.; Whiteley, J.M.
The effect of specific amino acid modifications on the catalytic properties of rat liver dihydropteridine reductase
Arch. Biochem. Biophys.
206
145-152
1981
Rattus norvegicus
Bailey, S.W.; Ayling, J.E.
6,6-Dimethylpterins: stable quinoid dihydropterin substrate for dihydropteridine reductase and tetrahydropterin cofactor for phenylalanine hydroxylase
Biochemistry
22
1790-1798
1983
Bos taurus, Ovis aries
Armarego, W.L.F.; Waring, P.
Inhibition of human brain dihydropteridine reductase [E.C.1.6.99.10] by the oxidation products of catecholamines, the aminochromes
Biochem. Biophys. Res. Commun.
113
895-899
1983
Homo sapiens
Shen, R.S.
Potent inhibitory effects of tyrosine metabolites on dihydropteridine reductase from human and sheep liver
Biochim. Biophys. Acta
785
181-185
1984
Ovis aries, Homo sapiens, Rattus norvegicus
Abell, C.W.; Shen, R.S.; Gessner, W.; Brossi, A.
Inhibition of dihydropteridine reductase by novel 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs
Science
224
405-407
1984
Homo sapiens, Rattus norvegicus
Shen, R.S.; Smith, R.V.; Davis, P.J.; Abell, C.W.
Inhibition of dihydropteridine reductase from human liver and rat striatal synaptosomes by apomorphine and its analogs
J. Biol. Chem.
259
8994-9000
1984
Homo sapiens, Rattus norvegicus
Randles, D.; Armarego, L.F.
Reduced 6,6,8-trimethylpterins. Preparation, properties and enzymic reactivities with dihydropteridine reductase, phenylalanine hydroxylase and tyrosine hydroxylase
Eur. J. Biochem.
146
467-474
1985
Ovis aries
Armarego, W.L.F.; Ohnishi, A.; Taguchi, H.
New pteridine substrates for dihydropteridine reductase and horseradish peroxidase
Biochem. J.
234
335-342
1986
Homo sapiens
Shen, R.S.
Inhibition of dihydropteridine reductase by catecholamines and related compounds
Biochim. Biophys. Acta
743
129-135
1983
Homo sapiens
Armarego, W.L.F.; Ohnishi, A.
Inactivation of dihydropteridine reductase (human brain) by platinum(II) complexes
Eur. J. Biochem.
164
403-409
1987
Homo sapiens
Nakanishi, N.; Ozawa, K.; Yamada, S.
Determination of NADPH-specific dihydropteridine reductase in extract from human, monkey, and bovine livers by single radial immunodiffusion: selective assay differentiating NADPH- and NADH-specific enzymes
J. Biochem.
99
1311-1315
1986
Bos taurus, Homo sapiens, Macaca fascicularis
Waring, P.
The time-dependent inactivation of human brain dihydropteridine reductase by the oxidation products of L-dopa
Eur. J. Biochem.
155
305-310
1986
Homo sapiens
Shen, R.S.; Smith, R.V.; Davis, P.J.; Brubaker, A.; Abell, C.W.
Dopamine-derived tetrahydroisoquinolines. Novel inhibitors of dihydropteridine reductase
J. Biol. Chem.
257
7294-7297
1982
Homo sapiens
Nakanishi, N.; Hirayama, K.; Yamada, S.
A simple procedure for purification of NADH-specific dihydropteridine reductase from mammalian liver
J. Biochem.
92
1033-1040
1982
Bos taurus, Homo sapiens, Rattus norvegicus
Musacchio, J.M.
Beef adrenal medulla dihydropteridine reductase
Biochim. Biophys. Acta
191
485-487
1969
Bos taurus
Nielsen, K.H.; Simonsen, V.; Lind, K.E.
Dihydropteridine reductase. A method for the measurement of activity, and investigations of the specificity for NADH and NADPH
Eur. J. Biochem.
9
497-502
1969
Bos taurus, Oryctolagus cuniculus, Felis catus, Ovis aries, Rattus norvegicus
Hirayama, K.; Nakanisi, N.; Sueoka, T.; Katoh, S.; Yamada, S.
Dihydropteridine reductase and tetrahydropterin in Crithidia fasciculata cells
Biochim. Biophys. Acta
612
337-343
1980
Crithidia fasciculata
Firgaira, F.A.; Cotton, G.H.; Danks, D.M.
Isolation and characterization of dihydropteridine reductase from human liver
Biochem. J.
197
31-43
1981
Homo sapiens
Nakanishi, N.; Hasegawa, H.; Watabe, S.
A new enzyme, NADPH-dihydropteridine reductase in bovine liver
J. Biochem.
81
681-685
1977
Bos taurus
Craine, J.E.; Hall, E.S.; Kaufman, S.
The isolation and characterization of dihydropteridine reductase from sheep liver
J. Biol. Chem.
247
6082-6091
1972
Ovis aries, Homo sapiens, Rattus norvegicus
Lind, K.E.
Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines
Eur. J. Biochem.
25
560-562
1972
Rattus norvegicus
Vasudevan, S.G.; Shaw, D.C.; Armarego, W.L.F.
Dihydropteridine reductase from Escherichia coli
Biochem. J.
255
581-588
1988
Escherichia coli
Webber, S.; Hural, J.A.; Whiteley, J.M.
Multiple forms of rat-liver dihydropteridine reductase identified by their differing isoelectric points
Arch. Biochem. Biophys.
248
358-367
1986
Rattus norvegicus
Nakanishi, N.; Hasegawa, H.; Yamada, S.; Akino, M.
Purification and physicochemical properties of NADPH-specific dihydropteridine reductase from bovine and human livers
J. Biochem.
99
635-644
1986
Bos taurus, Homo sapiens
Nakanishi, N.; Hasegawa, H.; Akino, M.; Yamada, S.
Catalytic properties of NADPH-specific dihydropteridine reductase from bovine liver
J. Biochem.
99
645-652
1986
Bos taurus
Su, Y.; Varughese, K.I.; Xuong, N.H.; Bray, T.L.; Roche, D.J.; Whiteley, J.M.
The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue
J. Biol. Chem.
268
26836-26841
1993
Homo sapiens
Varughese, K.I.; Xuong, N.H.; Whiteley, J.M.
Structural and mechanistic implications of incorporating naturally occurring aberrant mutations of human dihydropteridine reductase into a rat model
Int. J. Pept. Protein Res.
44
278-287
1994
Homo sapiens
Varughese, K.I.; Xuong, N.H.; Kiefer, P.M.; Matthews, D.A.; Whiteley, J.M.
Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases
Proc. Natl. Acad. Sci. USA
91
5582-5586
1994
Rattus norvegicus
Zhang, H.P.; Yang, N.; Armarego, W.L.F.
In vitro mutagenesis of human dihydropteridine reductase at the active site and at altered sites found in the reductases of deficient children
Pteridines
7
123-136
1996
Homo sapiens
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Kiefer, P.M.; Varughese, K.I.; Su, Y.; Xuong, N.H.; Chang, C.F.; Gupta, P.; Bray, T.; Whiteley, J.M.
Altered structural and mechanistic properties of mutant dihydropteridine reductases
J. Biol. Chem.
271
3437-3444
1996
Rattus norvegicus
Altindag, Z.; Sahin, G.
The change in dihydropteridin reductase activity in some diseases
Pharm. Sci.
2
335-337
1996
Homo sapiens
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Kiefer, P.M.; Grimshaw, C.E.; Whiteley, J.M.
The comparative interaction of quinonoid (6R)-Dihydrobiopterin and an alternative dihydropterin substrate with wild-type and mutant rat dihydropteridine reductases
Biochemistry
36
9438-9445
1997
Rattus norvegicus
Chang, C.F.; Bray, T.; Varughese, K.I.; Whiteley, J.M.
Comparative properties of three pteridine reductases
Adv. Exp. Med. Biol.
463
403-410
1999
Rattus norvegicus
Park, D.; Park, S.; Yim, J.
Molecular characterization of Drosophila melanogaster dihydropteridine reductase
Biochim. Biophys. Acta
1492
247-251
2000
Drosophila melanogaster
Wild, C.; Golderer, G.; Grobner, P.; Werner-Felmayer, G.; Werner, E.R.
Physarum polycephalum expresses a dihydropteridine reductase with selectivity for pterin substrates with a 6-(1', 2'-dihydroxypropyl) substitution
Biol. Chem.
384
1057-1062
2003
Physarum polycephalum (Q8WTJ2), Physarum polycephalum
Wilquet, V.; Van de Casteele, M.; Gigot, D.; Legrain, C.; Glansdorff, N.
Dihydropteridine reductase as an alternative to dihydrofolate reductase for synthesis of tetrahydrofolate in Thermus thermophilus
J. Bacteriol.
186
351-355
2004
Thermus thermophilus, Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
Hasse, S.; Gibbons, N.C.; Rokos, H.; Marles, L.K.; Schallreuter, K.U.
Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress
J. Invest. Dermatol.
122
307-313
2004
Homo sapiens (P09417), Homo sapiens
Thoeny, B.; Blau, N.
Mutations in the BH4-metabolizing genes GTP cyclohydrolase I, 6-pyruvoyl-tetrahydropterin synthase, sepiapterin reductase, carbinolamine-4a-dehydratase, and dihydropteridine reductase
Hum. Mutat.
27
870-878
2006
Homo sapiens
Schormann, N.; Pal, B.; Senkovich, O.; Carson, M.; Howard, A.; Smith, C.; Delucas, L.; Chattopadhyay, D.
Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor
J. Struct. Biol.
152
64-75
2005
Trypanosoma cruzi
Perez-Reinado, E.; Roldan, M.D.; Castillo, F.; Moreno-Vivian, C.
The NprA nitroreductase required for 2,4-dinitrophenol reduction in Rhodobacter capsulatus is a dihydropteridine reductase
Environ. Microbiol.
10
3174-3183
2008
Rhodobacter capsulatus
Concolino, D.; Muzzi, G.; Rapsomaniki, M.; Moricca, M.T.; Pascale, M.G.; Strisciuglio, P.
Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients
J. Inherit. Metab. Dis.
Suppl. 2
193-197
2008
Homo sapiens
Chen, C.; Seo, K.H.; Kim, H.L.; Zhuang, N.; Park, Y.S.; Lee, K.H.
Crystallization and preliminary characterization of dihydropteridine reductase from Dictyostelium discoideum
Acta Crystallogr. Sect. F
64
1013-1015
2008
Dictyostelium discoideum
Lee, C.K.; Han, J.S.; Won, K.J.; Jung, S.H.; Park, H.J.; Lee, H.M.; Kim, J.; Park, Y.S.; Kim, H.J.; Park, P.J.; Park, T.K.; Kim, B.
Diminished expression of dihydropteridine reductase is a potent biomarker for hypertensive vessels
Proteomics
9
4851-4858
2009
Rattus norvegicus
Manjarrez-Gutierrez, G.; Gonzalez-Ramirez, M.; Boyzo-Montes de Oca, A.; Hernandez-Rodriguez, J.
Dihydropteridine reductase activity in the brainstem of intrauterine growth-restricted rats
Int. J. Dev. Neurosci.
28
621-624
2010
Rattus norvegicus
Gu, Y.; Gong, Y.; Zhang, H.; Dong, X.; Zhao, T.; Burczynski, F.J.; Wang, G.; Sun, S.; Zhu, B.; Han, W.; Wang, H.; Li, P.
Regulation of transforming growth factor beta 1 gene expression by dihydropteridine reductase in kidney 293T cells
Biochem. Cell Biol.
91
187-193
2013
Rattus norvegicus
Chen, C.; Kim, H.L.; Zhuang, N.; Seo, K.H.; Park, K.H.; Han, C.D.; Park, Y.S.; Lee, K.H.
Structural insights into the dual substrate specificities of mammalian and Dictyostelium dihydropteridine reductases toward two stereoisomers of quinonoid dihydrobiopterin
FEBS Lett.
585
2640-2646
2011
Dictyostelium discoideum (Q86A17), Dictyostelium discoideum
Schmidt, K.; Kolesnik, B.; Gorren, A.; Werner, E.; Mayer, B.
Cell type-specific recycling of tetrahydrobiopterin by dihydrofolate reductase explains differential effects of 7,8-dihydrobiopterin on endothelial nitric oxide synthase uncoupling
Biochem. Pharmacol.
90
246-253
2014
Homo sapiens (P09417), Sus scrofa (Q8MJ30)
Li, W.; Gong, M.; Shu, R.; Li, X.; Gao, J.; Meng, Y.
Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori
Comp. Biochem. Physiol. B
186
20-27
2015
Bombyx mori
Xu, Y.; Li, Y.; Li, L.; Zhang, L.; Ding, Z.; Shi, G.
Reductase-catalyzed tetrahydrobiopterin regeneration alleviates the anti-competitive inhibition of tyrosine hydroxylation by 7,8-dihydrobiopterin
Catal. Sci. Technol.
11
3128-3140
2021
Escherichia coli (P38489)
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