1.5.1.34: 6,7-dihydropteridine reductase

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For detailed information about 6,7-dihydropteridine reductase, go to the full flat file.

Reaction

Synonyms

7,8-dihydrobiopterin reductase, BmDhpr, DHPR, dicDHPR, dihydropteridine reductase, dihydropteridine reductase (NADH), DQPR gene product, EC 1.6.99.10, EC 1.6.99.7, EcDHPR, More, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, NfsB, NprA nitroreductase, PTR2, QDPR, quinoid dihydropteridine reductase, reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide)

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.34 6,7-dihydropteridine reductase

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Results	in table
1596	AA Sequence
2	Application
2	CAS Registry Number
15	Cloned(Commentary)
89	Cofactor
7	Crystallization (Commentary)
719	Disease/ Diagnostics
1	Expression
12	General Information
5	General Stability
1	IC50 Value
161	Inhibitors
52	Ki Value [mM]
194	KM Value [mM]
4	Localization
48	Molecular Weight [Da]
18	Natural Substrates/ Products (Substrates)
108	Organism
6	Pathway
29	PDB ID
13	pH Optimum
2	pH Range
1	pH Stability
2	pI Value
30	Protein Variants
35	Purification (Commentary)
4	Reaction
3	Reaction Type
86	Reference
70	Source Tissue
40	Specific Activity [micromol/min/mg]
6	Storage Stability
131	Substrates and Products (Substrate)
29	Subunits
43	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
2	Temperature Stability [°C]
65	Turnover Number [1/s]

Application

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Application on EC 1.5.1.34 - 6,7-dihydropteridine reductase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

medicine

Homo sapiens

-

enzyme deficiency leads to progressive mental and physical retardation despite dietary phenylalanine restriction. Overview on genomic structure and location of natural mutations in the QDPR gene coding for enzyme

668883

additional information

Escherichia coli

P38489

the purified recombinant enzyme from Escherichia coli is used for 5,6,7,8-tetrahydropteridine (BH4) regeneration to alleviate 7,8-dihydropteridine (BH2) inhibition of L-tyrosine hydroxylation by crude tyrosine hydroxylase (SrTH) from Streptosporangium roseum DSM 43021 as part of a combined whole-cell catalyst, and a series of tyrosine hydroxylase/sepiapterin reductase (TH/SPR) synthesis systems, overview

764413