1.5.1.27: 1,2-dehydroreticulinium reductase (NADPH)

This is an abbreviated version!
For detailed information about 1,2-dehydroreticulinium reductase (NADPH), go to the full flat file.

Reaction

Synonyms

1,2 dehydroreticuline reductase, 1,2-Dehydroreticuline reductase, 1,2-Dehydroreticulinium ion reductase, DRR, NADPH 1,2-dehydroreticuline reductase, PrDRR, PsDRR1, PsREPI, Reductase, 1,2-dehydroreticuline, reticuline epimerase, STORR

ECTree

     1 Oxidoreductases

         1.5 Acting on the CH-NH group of donors

             1.5.1 With NAD⁺ or NADP⁺ as acceptor

                1.5.1.27 1,2-dehydroreticulinium reductase (NADPH)

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1	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
7	Cofactor
6	General Information
2	General Stability
21	Inhibitors
6	KM Value [mM]
4	Localization
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
20	Organism
6	Pathway
7	pH Optimum
1	Protein Variants
3	Purification (Commentary)
1	Reaction
2	Reaction Type
19	Reference
5	Source Tissue
2	Specific Activity [micromol/min/mg]
5	Storage Stability
19	Substrates and Products (Substrate)
2	Subunits
15	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 1.5.1.27 - 1,2-dehydroreticulinium reductase (NADPH)

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SYSTEMATIC NAME

IUBMB Comments

(R)-reticuline:NADP+ oxidoreductase

Reduces the 1,2-dehydroreticulinium ion to (R)-reticuline, which is a direct precursor of morphinan alkaloids in the poppy plant. The enzyme does not catalyse the reverse reaction to any significant extent under physiological conditions.