1.5.1.25: thiomorpholine-carboxylate dehydrogenase
This is an abbreviated version!
For detailed information about thiomorpholine-carboxylate dehydrogenase, go to the full flat file.
Word Map on EC 1.5.1.25
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1.5.1.25
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thyroid
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nadph-dependent
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bioavailability
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cerebral
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unsaturated
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ovine
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l-cystathionine
- 1.5.1.25
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thyroid
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nadph-dependent
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bioavailability
- cerebral
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unsaturated
-
ovine
- l-cystathionine
Reaction
Synonyms
CRYM, CtBP, cytosolic thyroid hormone binding protein, DELTA1-piperideine-2-carboxylate reductase, ketimine reductase, ketimine-reducing enzyme, KR/CRYM/CTBP, More, mu-crystallin, P2C reductase, PLP-dependent amino acid gamma-substitution enzyme, PYCR2, Pyr2C reductase, reductase, ketimine, THBP, thyroid hormone binding protein, Thyroid hormone-binding protein
ECTree
1.5.1.25 thiomorpholine-carboxylate dehydrogenaseAdvanced search results
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results (Source Tissue
Source Tissue on EC 1.5.1.25 - thiomorpholine-carboxylate dehydrogenase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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high enzyme expression level, expression of the CRYM transcript follows the hair growth cycle with a significant increase in expression during mid- and late anagen growth phases
additional information
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CRYM/KR mRNA in the mouse is most highly expressed in skin among the tissues evaluated, followed by brain and heart
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very low expression in cerebellum compared to cerebrum, high overall expression level
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levels of thyroid hormone binding capacity for cytosolic NADPH-dependent T3 binding are noticeably lower in the cerebellum than in the cerebrum of adult rat brain at all stages of development. NADPH-dependent T3 binding is only detected in kidney, liver, heart and spleen after birth, increasing over the next 6 weeks. NADPH-dependent T3 binding is detected in cerebrum and cerebellum 5 days before birth, increasing with a sharp transient spike at the time of birth, that is specific for the brain, particularly in cerebrum, and cannot be seen in other tissues. The NADPH-dependent T3 binding in cerebrum decreases after birth, but begins to increase again 2 weeks after birth. The level in cerebellum does not show this increase. The brain may contain at least two distinct P2C reductases/ketimine reductase, one of which is predominant in the fore-brain and another that is prominent in the cerebellum
