1.5.1.22: Strombine dehydrogenase

This is an abbreviated version!
For detailed information about Strombine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.1.22

Reaction

N-(carboxymethyl)-D-alanine
+
NAD+
+
H2O
=
glycine
+
pyruvate
+
NADH
+
H+

Synonyms

Dehydrogenase, strombine, SDH, St/AlDH1, St/AlDH2, St/AlDH3, StDH, STRDH, strombine dehydrogenase, strombine/alanopine dehydrogenase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.22 Strombine dehydrogenase

Substrates Products

Substrates Products on EC 1.5.1.22 - Strombine dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ala + pyruvate + NADH
meso-alanopine + NAD+ + H2O
show the reaction diagram
Paraprionospio pinnata
-
-
-
-
?
beta-Ala + pyruvate + NADH
?
show the reaction diagram
-
-
-
-
?
Gly + 2-ketobutyrate + NADH + H+
2-[(carboxymethyl)amino]butanoic acid + NAD+ + H2O
show the reaction diagram
8.9% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + 2-oxobutanoate + NADH
?
show the reaction diagram
Gly + 2-oxopentanoate + NADH
?
show the reaction diagram
-
19.6% of the activity with pyruvate
-
-
-
Gly + glyoxylate + NADH
?
show the reaction diagram
Gly + glyoxylate + NADH + H+
[(carboxymethyl)amino]propanedioic acid + NAD+ + H2O
show the reaction diagram
3.9% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + hydroxypyruvate + NADH
?
show the reaction diagram
-
29.5% of the activity with pyruvate
-
-
-
Gly + oxaloacetate + NADH
?
show the reaction diagram
-
106% of the activity with pyruvate
-
-
-
Gly + oxaloacetate + NADH + H+
N-carboxymethylglycine + NAD+ + H2O
show the reaction diagram
39.1% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + pyruvate + NADH
D-Strombine + NAD+ + H2O
show the reaction diagram
Gly + pyruvate + NADH + H+
D-strombine + NAD+ + H2O
show the reaction diagram
94.6% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
Gly + pyruvate + NADPH
D-strombine + NADP+ + H2O
show the reaction diagram
less than 0.5% activity compared to Gly + pyruvate + NADH with isozyme St/AlDH1
-
-
?
glycine + pyruvate + NADH
D-strombine + NAD+ + H2O
show the reaction diagram
glycine + pyruvate + NADH + H+
N-(carboxymethyl)-D-alanine + NAD+ + H2O
show the reaction diagram
-
the reduction reaction is preferred
-
-
r
L-2-Aminobutanoate + pyruvate + NADH
?
show the reaction diagram
L-2-Aminobutyrate + pyruvate + NADH
?
show the reaction diagram
-
-
-
-
?
L-Ala + 2-ketobutyrate + NADH + H+
2-[[(1S)-1-carboxyethyl]amino]butanoic acid + NAD+ + H2O
show the reaction diagram
8.9% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ala + glyoxylate + NADH + H+
N-(carboxymethyl)-L-Ala + NAD+ + H2O
show the reaction diagram
4.0% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ala + oxaloacetate + NADH + H+
[[(1S)-1-carboxyethyl]amino]propanedioic acid + NAD+ + H2O
show the reaction diagram
40.0% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Ala + pyruvate + NADH
?
show the reaction diagram
-
Gly and Ala are preferred substrates
-
-
?
L-Ala + pyruvate + NADH
meso-Alanopine + NAD+ + H2O
show the reaction diagram
L-Ala + pyruvate + NADH + H+
meso-alanopine + NAD+ + H2O
show the reaction diagram
100% activity
-
-
?
L-Ala + pyruvate + NADPH
meso-alanopine + NADP+ + H2O
show the reaction diagram
less than 0.5% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Cys + pyruvate + NADH
?
show the reaction diagram
-
19.9% of the activity with Gly
-
-
-
L-Cys + pyruvate + NADH + H+
N-(1-carboxyethyl)-L-Cys + NAD+ + H2O
show the reaction diagram
1.7% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Met + pyruvate + NADH
?
show the reaction diagram
-
3.7% of the activity with Gly
-
-
-
L-Ser + pyruvate + NADH
?
show the reaction diagram
L-Ser + pyruvate + NADH + H+
N-(1-carboxyethyl)-L-Ser + NAD+ + H2O
show the reaction diagram
14.2% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
L-Thr + pyruvate + NADH
?
show the reaction diagram
L-Val + pyruvate + NADH
?
show the reaction diagram
-
11.2% of the activity with Gly
-
-
-
L-Val + pyruvate + NADH + H+
N-(1-carboxyethyl)-L-Val + NAD+ + H2O
show the reaction diagram
0.9% activity compared to L-Ala + pyruvate + NADH with isozyme St/AlDH1
-
-
?
additional information
?
-
-
the enzyme functions as the terminal dehydrogenase of glycolysis and has a role in maintaining energy production under the stresses of environmental or functional anoxia
-
-
-