1.5.1.22: Strombine dehydrogenase

This is an abbreviated version!
For detailed information about Strombine dehydrogenase, go to the full flat file.

Word Map on EC 1.5.1.22

Reaction

N-(carboxymethyl)-D-alanine
+
NAD+
+
H2O
=
glycine
+
pyruvate
+
NADH
+
H+

Synonyms

Dehydrogenase, strombine, SDH, St/AlDH1, St/AlDH2, St/AlDH3, StDH, STRDH, strombine dehydrogenase, strombine/alanopine dehydrogenase

ECTree

     1 Oxidoreductases
         1.5 Acting on the CH-NH group of donors
             1.5.1 With NAD+ or NADP+ as acceptor
                1.5.1.22 Strombine dehydrogenase

Inhibitors

Inhibitors on EC 1.5.1.22 - Strombine dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetate
-
-
D-lactate
D-strombine
-
-
iminodiacetate
-
-
iminodiacetic acid
-
-
L-lactate
meso-Alanopine
oxaloacetate
-
-
pyruvate
inhibited by an excess of substrate pyruvate; substrate inhibition, in excess, pyruvate enters in competition with the other substrate (glycine and/or NADH) preventing the site of reaction to take all the substrates to proceed with the enzymatic reaction. Its optimal concentration is determined to be round 2.0-2.3 mM
succinate
additional information
-
the enzyme activity in adductor muscle decreases following the marine-brackish gradient
-