1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]

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For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.5.1.20

1.5.1.20

nitrite

homocysteine

medicine

paracoccus

assimilatory

denitrification

chlorate

narghi

resde

napc

molybdoenzyme

pantotrophus

ammonification

nutrition

analysis

Reaction

Synonyms

10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

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Results	in table
9	Activating Compound
46906	AA Sequence
26	Application
2	CAS Registry Number
19	Cloned(Commentary)
150	Cofactor
9	Crystallization (Commentary)
177	Disease/ Diagnostics
18	General Information
8	General Stability
9	IC50 Value
68	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
70	KM Value [mM]
13	Localization
12	Metals/Ions
31	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
291	Organism
2	Oxidation Stability
6	Pathway
37	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
4	Posttranslational Modification
175	Protein Variants
26	Purification (Commentary)
9	Reaction
3	Reaction Type
261	Reference
1	Renatured (Commentary)
125	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
280	Substrates and Products (Substrate)
30	Subunits
407	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

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Synonyms on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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10-methylenetetrahydrofolate reductase

Homo sapiens

688057, 688135

5,10-CH2-H4folate reductase

5,10-methylenetetrahydrofolate reductase

3 entries

5,10-methylenetetrahydrofolate reductase (FADH2)

Escherichia coli

654695

5,10-methylenetetrahydrofolate reductase (NADPH)

5,10-methylenetetrahydrofolic acid reductase

5,10-methylenetetrahydropteroylglutamate reductase

5-methylenetetrahydrofolate:NADP+ oxidoreductase

Escherichia coli

654695

5-methyltetrahydrofolate:(acceptor) oxidoreductase

Escherichia coli

654695

5-methyltetrahydrofolate:NAD oxidoreductase

5-methyltetrahydrofolate:NAD+ oxidoreductase

5-methyltetrahydrofolate:NADP+ oxidoreductase

AtMTHFR-1

Arabidopsis thaliana

656085

EC 1.1.1.171

formerly

EC 1.1.1.68

formerly

EC 1.1.99.15

formerly

EC 1.7.99.5

formerly

HsMTHFR

MET13

methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase

methylenetetrahydrofolate reductase

66 entries

methylenetetrahydrofolate reductase (NADPH)

2 entries

methylenetetrahydrofolic acid reductase

MetVF-type methylenetetrahydrofolate reductase

2 entries

MTHFR

69 entries

MTHFR2

N5,10-methylenetetrahydrofolate reductase

N5,N10-methylenetetrahydrofolate reductase

NADH:CH2-H4folate oxidoreductase

2 entries

NapAB

Cereibacter sphaeroides

659990

reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate)

reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide)

respiratory nitrate reductase

Cereibacter sphaeroides

659990

type II-MTHFR

2 entries

additional information

Escherichia coli

EC 1.7.99.5 included with EC 1.5.1.20

654695