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(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+
(6S)-5-methyltetrahydrofolate + NAD(P)+
(6R,S)-5,10-methylenetetrahydrofolate + ?
?
1-pyrroline-5-carboxylate + NADH + H+
L-proline + NAD+
-
-
-
-
r
5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate + reduced acceptor
(+)-5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate + oxidized acceptor
-
equilibrium lies far in favor of 5-methyl-5,6,7,8-tetrahydropteroylpentaglutamate formation, pentaglutamate form binds to the same enzyme site as monoglutamate form
menadione as acceptor for 5,10-methylene-5,6,7,8-tetrahydropteroylpentaglutamate formation
?
5,10-methylenetetrahydrofolate + acceptor
5-methyltetrahydrofolate + reduced acceptor
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
5,10-methylenetetrahydrofolate + ferredoxin
5-methyltetrahydrofolate + reduced ferredoxin
5,10-methylenetetrahydrofolate + NAD(P)H
5-methyltetrahydrofolate + NAD(P)+
-
NADH is the preferred cofactor of the plant enzyme
-
-
r
5,10-methylenetetrahydrofolate + NAD(P)H + H+
5-methyltetrahydrofolate + NAD(P)+
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
5,10-methylenetetrahydrofolate + NADPH
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
5,10-methylenetetrahydrofolate + reduced ferredoxin
5-methyltetrahydrofolate + oxidized ferredoxin
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NADP+
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
5-methyltetrahydropteroylmonoglutamate + 5,10-methylenetetrahydropteroylhexaglutamate
5,10-methylenetetrahydropteroylmonoglutamate + 5-methyltetrahydropteroylhexaglutamate
-
-
-
r
NADH + menadione
NAD+ + reduced menadione
-
-
-
?
NADPH + H+ + menadione
NADP+ + menadiol
nitrate + reduced acceptor
nitrite + acceptor
nitrate + reduced benzyl viologen
nitrite + benzyl viologen
nitrate + reduced methyl viologen
nitrite + methyl viologen
additional information
?
-
(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+
(6S)-5-methyltetrahydrofolate + NAD(P)+
-
-
-
r
(6R)-5,10-methylenetetrahydrofolate + NAD(P)H + H+
(6S)-5-methyltetrahydrofolate + NAD(P)+
-
-
-
r
(6R,S)-5,10-methylenetetrahydrofolate + ?
?
-
-
-
-
?
(6R,S)-5,10-methylenetetrahydrofolate + ?
?
-
assay at 25°C
-
-
?
(6R,S)-5,10-methylenetetrahydrofolate + ?
?
-
-
-
-
?
5,10-methylenetetrahydrofolate + acceptor
5-methyltetrahydrofolate + reduced acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + acceptor
5-methyltetrahydrofolate + reduced acceptor
-
-
-
-
ir
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
-
enzyme in pathway of synthesis of acetate from CO2 via formate and a series of reactions involving tetrahydrofolate and a corrinoid, FADH2 and reduced ferredoxin may serve as natural reductants for 5,10-methylenetetrahydrofolate
-
?
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
-
-
-
-
?
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
-
biosynthesis of 5-methyltetrahydrofolate, a donor of methyl groups of methionine
-
-
?
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
-
-
-
-
?
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
-
biosynthesis of 5-methyltetrahydrofolate, a donor of methyl groups of methionine
-
-
?
5,10-methylenetetrahydrofolate + FADH2
5-methyltetrahydrofolate + FAD
-
first step of conversion of 5,10-methylenetetrahydrofolate to methionine
-
-
?
5,10-methylenetetrahydrofolate + ferredoxin
5-methyltetrahydrofolate + reduced ferredoxin
-
-
-
r
5,10-methylenetetrahydrofolate + ferredoxin
5-methyltetrahydrofolate + reduced ferredoxin
-
-
-
r
5,10-methylenetetrahydrofolate + NAD(P)H + H+
5-methyltetrahydrofolate + NAD(P)+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NAD(P)H + H+
5-methyltetrahydrofolate + NAD(P)+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NAD(P)H + H+
5-methyltetrahydrofolate + NAD(P)+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NAD(P)H + H+
5-methyltetrahydrofolate + NAD(P)+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NAD(P)H + H+
5-methyltetrahydrofolate + NAD(P)+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
-
folate-mediated one-carbon metabolism
-
r
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
-
-
-
?
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
-
physiological direction is the 5-methyltetrahydrofolate formation by transfer of reducing equivalents from NADH to the enzyme-bound FAD and from reduced FAD to methylenetetrahydrofolate
-
-
?
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
-
physiological direction: 5-methyltetrahydrofolate formation, inhibition by S-adenosylmethionine functions as a feedback-type metabolic regulation in vivo
-
?
5,10-methylenetetrahydrofolate + NADH
5-methyltetrahydrofolate + NAD+
folate-mediated one-carbon metabolism
-
r
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
-
-
-
-
r
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
-
-
-
r
5,10-methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate + NAD+
-
-
-
-
r
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
physiological NADPH-CH2-H4folate oxidoreductase activity
5-methyltetrahydrofolate is the major methyl donor for the conversion of homocysteine to methionine
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
equilibrium far on the side of methyltetrahydrofolate formation
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
specific for (+)-diastereoisomer
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
-
-
r
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
enzyme encoded by MET13 produces 5-methyltetrahydrofolate used for methylation of homocysteine for methionine biosynthesis in vivo, NADPH is the likely natural reductant
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
enzyme encoded by MET13 produces 5-methyltetrahydrofolate used for methylation of homocysteine for methionine biosynthesis in vivo, NADPH is the likely natural reductant
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
-
-
-
ir
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
ping pong bi bi mechanism
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
ferricyanide, dichlorophenolindophenol and cytochrome c can act as electron acceptors
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
equilibrium far on the side of methyltetrahydrofolate formation
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
ping pong kinetics
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
enzyme catalyzes the reduction of quinoid dihydropterins without a 5-substituent
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
enzyme also catalyzes the NADPH-linked reduction of quinoid dihydrofolate and dihydropterin derivates
-
-
?
5,10-methylenetetrahydrofolate + NADPH
5-methyltetrahydrofolate + NADP+
-
specific for (+)-diastereoisomer
-
-
?
5,10-methylenetetrahydrofolate + NADPH
?
-
first step in biosynthesis of methyl groups
-
-
?
5,10-methylenetetrahydrofolate + NADPH
?
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH
?
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADPH
?
-
branch point in folate metabolism
-
-
?
5,10-methylenetetrahydrofolate + NADPH
?
-
initial enzyme in pathway leading to synthesis of S-adenosylmethionine
-
-
?
5,10-methylenetetrahydrofolate + NADPH
?
-
overview: role in incorporation of methyltetrahydrofolate into cellular metabolism
-
-
?
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
-
-
-
r
5,10-methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate + NADP+
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: strong preference of NADH over NADPH
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: FAD, rubredoxin, benzyl viologen and methylene blue as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: FAD, rubredoxin, benzyl viologen and methylene blue as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced ferredoxin as reduced acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced ferredoxin as reduced acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
under anaerobic conditions and in absence of electron acceptors, the equilibrium lies far to the 5-methyltetrahydrofolate formation, inclusion of menadione or oxygen promotes the oxidation of 5-methyltetrahydrofolate
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
prefers NADH as reductant
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADPH as reduced acceptor
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADH as reduced acceptor
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADH as reduced acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
under anaerobic conditions and in absence of electron acceptors, the equilibrium lies far to the 5-methyltetrahydrofolate formation, inclusion of menadione or oxygen promotes the oxidation of 5-methyltetrahydrofolate
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
685862, 685893, 685988, 685995, 686128, 686133, 686144, 686158, 686185, 686240, 686310, 686329, 686497, 686513, 686515, 686517, 686540, 686572, 686592, 686633, 686835, 686994, 687946, 687957, 688057, 688129, 688135, 688140, 688142, 688184, 688554, 688565, 688688, 688704, 688709, 689031, 689103, 689111, 689166, 689282, 689284, 689298, 689329, 689330, 689333, 690042, 690049, 690112, 690124, 690212 -
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
ir
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADPH as reduced acceptor
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
supply of the folate needed for the metabolism of homocysteine: 5-methyltetrahydrofolate is required for the methylation of homocysteine to methionine
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
homocysteine metabolism
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
homocysteine metabolism
5-methyltetrahydrofolate is the main form of circulating folate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
physiological direction is the 5-methyltetrahydrofolate formation
5-methyltetrahydrofolate is the main form of circulating folate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
remethylation of homocysteine to methionine
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
remethylation of homocysteine to methionine
5-methyltetrahydrofolate is the main form of circulating folate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
ir
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
product is (+)-5-methyl-5,6,7,8-tetrahydropteroylmonoglutamate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
5,10-methylene-5,6,7,8-tetrahydropteroylmonoglutamate as substrate
product is (+)-5-methyl-5,6,7,8-tetrahydropteroylmonoglutamate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
equilibrium lies far in favor of 5-methyltetrahydrofolate formation
product is (+)-5-methyl-5,6,7,8-tetrahydropteroylmonoglutamate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
product is (+)-5-methyl-5,6,7,8-tetrahydropteroylmonoglutamate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADH as reduced acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADH as reduced acceptor
product is (+)-5-methyl-5,6,7,8-tetrahydropteroylmonoglutamate
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
equilibrium lies far in favor of 5-methyltetrahydrofolate formation
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADPH as reduced acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
equilibrium lies far in favor of 5-methyltetrahydrofolate formation
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADPH as reduced acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: reduced acceptor is FADH2
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
forward reaction: NADPH as reduced acceptor causes irreversible reduction of the flavin coenzyme FAD
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
reverse reaction: menadione as electron acceptor
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
forward reaction: strong preference of NADH over NADPH
-
r
5,10-methylenetetrahydrofolate + reduced acceptor
5-methyltetrahydrofolate + oxidized acceptor
-
-
-
?
5,10-methylenetetrahydrofolate + reduced ferredoxin
5-methyltetrahydrofolate + oxidized ferredoxin
-
enzyme in pathway of synthesis of acetate from CO2 via formate and a series of reactions involving tetrahydrofolate and a corrinoid, FADH2 and reduced ferredoxin may serve as natural reductants for 5,10-methylenetetrahydrofolate, electron transfer from reduced ferredoxin via iron-sulfur centers via enzyme-bound FAD to 5,10-methylenetetrahydrofolate
-
?
5,10-methylenetetrahydrofolate + reduced ferredoxin
5-methyltetrahydrofolate + oxidized ferredoxin
-
physiological important reaction: enzyme catalyzes reduction of 5,10-methylenetetrahydrofolate with reduced ferredoxin
-
?
5,10-methylenetetrahydrofolate + reduced ferredoxin
5-methyltetrahydrofolate + oxidized ferredoxin
-
physiological important reaction: enzyme catalyzes reduction of 5,10-methylenetetrahydrofolate with reduced ferredoxin
-
?
5,10-methylenetetrahydrofolate + reduced ferredoxin
5-methyltetrahydrofolate + oxidized ferredoxin
-
enzyme is part of synthesis pathway of acetate from CO2 via a unique tetrahydrofolate-corrinoid pathway
-
?
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH
-
-
-
-
r
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH
-
-
-
-
?
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH + H+
-
-
-
-
r
5-methyltetrahydrofolate + NAD+
5,10-methylenetetrahydrofolate + NADH + H+
-
-
-
-
r
5-methyltetrahydrofolate + NADP+
5,10-methylenetetrahydrofolate + NADPH
-
-
-
-
?
5-methyltetrahydrofolate + NADP+
5,10-methylenetetrahydrofolate + NADPH
-
-
-
-
?
5-methyltetrahydrofolate + NADP+
5,10-methylenetetrahydrofolate + NADPH
-
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
-
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
-
-
-
-
?
5-methyltetrahydrofolate + oxidized menadione
5,10-methylenetetrahydrofolate + reduced menadione
-
ping pong kinetics
-
-
?
NADPH + H+ + menadione
NADP+ + menadiol
-
-
-
?
NADPH + H+ + menadione
NADP+ + menadiol
-
-
-
-
?
NADPH + H+ + menadione
NADP+ + menadiol
-
ping pong kinetics
-
-
?
nitrate + reduced acceptor
nitrite + acceptor
-
the enzyme is responsible for anaerobic growth of Bradyrhizobium japonicum under nitrate-respiring conditions
-
-
?
nitrate + reduced acceptor
nitrite + acceptor
-
the enzyme is responsible for anaerobic growth of Bradyrhizobium japonicum under nitrate-respiring conditions
-
-
?
nitrate + reduced benzyl viologen
nitrite + benzyl viologen
-
-
-
-
?
nitrate + reduced benzyl viologen
nitrite + benzyl viologen
-
-
-
-
?
nitrate + reduced benzyl viologen
nitrite + benzyl viologen
-
-
-
-
?
nitrate + reduced methyl viologen
nitrite + methyl viologen
-
-
-
-
?
nitrate + reduced methyl viologen
nitrite + methyl viologen
-
-
-
-
?
nitrate + reduced methyl viologen
nitrite + methyl viologen
-
-
-
-
?
additional information
?
-
-
the enzyme is responsible for the first step in the denitrification process
-
-
?
additional information
?
-
-
no direct activity with pyridine nucleotides
-
-
?
additional information
?
-
-
no direct activity with pyridine nucleotides
-
-
?
additional information
?
-
-
not as electron donor: reduced rubredoxin
-
-
?
additional information
?
-
reduced methyl viologen is used as electron donor and the MVred:methylene-THF oxidoreductase activity is followed during the purification procedure. Analysis of carbon and electron flow during acetogenesis from H2 + CO2 or CO
-
-
-
additional information
?
-
reduced methyl viologen is used as electron donor and the MVred:methylene-THF oxidoreductase activity is followed during the purification procedure. Analysis of carbon and electron flow during acetogenesis from H2 + CO2 or CO
-
-
-
additional information
?
-
-
no direct activity with pyridine nucleotides
-
-
?
additional information
?
-
-
catalytic mechanism, Asp-120 and Glu-28 at the flavin active site are relevant to catalysis, Asp-120: located near the enzyme-bound FAD, role in catalysis of folate reduction and in stabilization of the folate intermediate 5-iminium cation, Glu-28: located near N10 of the folate, general acid catalyst to aid in 5-iminium cation formation
-
-
?
additional information
?
-
-
no direct activity with pyridine nucleotides
-
-
?
additional information
?
-
-
in patients with defects in the enzyme the homocysteine concentrations are increased, hyperhomocysteinemia elevates the risk for cardiovascular disease
-
-
?
additional information
?
-
-
reverse reaction: not NADP+ as acceptor
-
-
?
additional information
?
-
-
reverse reaction: menadione and 2,6-dichlorophenolindophenol and NADP+ are not effective as electron acceptor
-
-
?
additional information
?
-
-
reverse reaction: menadione and 2,6-dichlorophenolindophenol and NADP+ are not effective as electron acceptor
-
-
?