1.5.1.20: methylenetetrahydrofolate reductase [NAD(P)H]

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For detailed information about methylenetetrahydrofolate reductase [NAD(P)H], go to the full flat file.

Word Map on EC 1.5.1.20

1.5.1.20

nitrite

homocysteine

medicine

paracoccus

assimilatory

denitrification

chlorate

narghi

resde

napc

molybdoenzyme

pantotrophus

ammonification

nutrition

analysis

Reaction

Synonyms

10-methylenetetrahydrofolate reductase, 5,10-CH2-H4folate reductase, 5,10-methylenetetrahydrofolate reductase, 5,10-methylenetetrahydrofolate reductase (FADH2), 5,10-methylenetetrahydrofolate reductase (NADPH), 5,10-methylenetetrahydrofolic acid reductase, 5,10-methylenetetrahydropteroylglutamate reductase, 5-methylenetetrahydrofolate:NADP+ oxidoreductase, 5-methyltetrahydrofolate:(acceptor) oxidoreductase, 5-methyltetrahydrofolate:NAD oxidoreductase, 5-methyltetrahydrofolate:NAD+ oxidoreductase, 5-methyltetrahydrofolate:NADP+ oxidoreductase, AtMTHFR-1, EC 1.1.1.171, EC 1.1.1.68, EC 1.1.99.15, EC 1.7.99.5, HsMTHFR, MET13, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase, methylenetetrahydrofolate reductase, methylenetetrahydrofolate reductase (NADPH), methylenetetrahydrofolic acid reductase, MetVF-type methylenetetrahydrofolate reductase, More, MTHFR, MTHFR2, N5,10-methylenetetrahydrofolate reductase, N5,N10-methylenetetrahydrofolate reductase, NADH:CH2-H4folate oxidoreductase, NapAB, reductase, methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate), reductase, methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide), respiratory nitrate reductase, type II-MTHFR

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.20 methylenetetrahydrofolate reductase [NAD(P)H]

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Results	in table
9	Activating Compound
46906	AA Sequence
26	Application
2	CAS Registry Number
19	Cloned(Commentary)
150	Cofactor
9	Crystallization (Commentary)
177	Disease/ Diagnostics
18	General Information
8	General Stability
9	IC50 Value
68	Inhibitors
4	kcat/KM [mM/s]
14	Ki Value [mM]
70	KM Value [mM]
13	Localization
12	Metals/Ions
31	Molecular Weight [Da]
50	Natural Substrates/ Products (Substrates)
291	Organism
2	Oxidation Stability
6	Pathway
37	PDB ID
16	pH Optimum
4	pH Range
1	pH Stability
4	Posttranslational Modification
175	Protein Variants
26	Purification (Commentary)
9	Reaction
3	Reaction Type
261	Reference
1	Renatured (Commentary)
125	Source Tissue
33	Specific Activity [micromol/min/mg]
6	Storage Stability
280	Substrates and Products (Substrate)
30	Subunits
407	Synonyms
1	Systematic Name
16	Temperature Optimum [°C]
1	Temperature Range [°C]
9	Temperature Stability [°C]
25	Turnover Number [1/s]

Molecular Weight

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Molecular Weight on EC 1.5.1.20 - methylenetetrahydrofolate reductase [NAD(P)H]

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106000

Clostridium ljungdahlii

A0A162J7F3

analytical gel filtration

764937

108000

Escherichia coli

P0AEZ1

A177V mutant enzyme, gel filtration

392163

124000

Clostridium formicaceticum

determination at pH 9, alpha2,beta2 enzyme form, PAGE

437714

133000

Escherichia coli

tetrameric enzyme, gel filtration

654695

136000

Sus scrofa

scanning transmission electron microscopy

141000

gel filtration

150000

gel filtration

170000 - 190000

gel filtration, single enzyme with methylenetetrahydrofolate reductase and dopamine methyltransferase activity

392150

190000

Escherichia coli

P0AEZ1

wild type enzyme, gel filtration

237000

26000

33000

4 * 33000

34800

x * 34800, calculated

35000

66000

66400

x * 66400, calculated from the nucleotide sequence

437724

69000

Schizosaccharomyces pombe

x * 69000, met9, SDS-PAGE, x *72100, met11, SDS-PAGE

657415

70000

Homo sapiens

x * 77000, SDS-PAGE, x * 70000, SDS-PAGE of MTHFR mutant c.523G>A or mutant c.1166G>A

75000

SDS-PAGE

77000

77300

SDS-PAGE