1.5.1.10: saccharopine dehydrogenase (NADP+, L-glutamate-forming)

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For detailed information about saccharopine dehydrogenase (NADP+, L-glutamate-forming), go to the full flat file.

Word Map on EC 1.5.1.10

1.5.1.10

alpha-aminoadipate

auxotrophs

magnaporthe

grisea

homocitrate

pipecolic

swainsonine

homoisocitrate

piperideine-6-carboxylic

chrysogenum

unlinked

rossmann

penicillium

ph-rate

endophytic

embedding

6-dehydrogenase

substrate-assisted

seven-stranded

diaminopimelate

oxytropis

acid-base

leaky

all-helical

anisotropic

l-pipecolate

dl-alpha-aminoadipate

gene-enzyme

Reaction

Synonyms

aminoadipate semialdehyde-glutamate reductase, aminoadipic semialdehyde-glutamate reductase, aminoadipic semialdehyde-glutamic reductase, ASS, dehydrogenase, saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming), epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming), LKR/SDH, lysine-ketoglutarate reductase/saccharopine dehydrogenase, nSpe-Sdh, saccharopine dehydrogenase, saccharopine dehydrogenase (L-glutamate forming), saccharopine reductase, SDH, spermidine synthase-saccharopine dehydrogenase, SR1

ECTree

1 Oxidoreductases

1.5 Acting on the CH-NH group of donors

1.5.1 With NAD⁺ or NADP⁺ as acceptor

1.5.1.10 saccharopine dehydrogenase (NADP+, L-glutamate-forming)

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Results	in table
2	Activating Compound
114	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
31	Cofactor
3	Crystallization (Commentary)
9	Expression
20	General Information
21	Inhibitors
8	KM Value [mM]
11	Localization
4	Metals/Ions
7	Molecular Weight [Da]
16	Natural Substrates/ Products (Substrates)
24	Organism
7	Pathway
11	PDB ID
10	pH Optimum
3	pH Range
1	pI Value
3	Posttranslational Modification
9	Protein Variants
7	Purification (Commentary)
2	Reaction
3	Reaction Type
24	Reference
19	Source Tissue
6	Specific Activity [micromol/min/mg]
1	Storage Stability
32	Substrates and Products (Substrate)
13	Subunits
42	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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Natural Substrates Products on EC 1.5.1.10 - saccharopine dehydrogenase (NADP+, L-glutamate-forming)

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2-aminoadipate 6-semialdehyde + L-glutamate + NADPH

N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O

5 entries

L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+

saccharopine + NADP+ + H2O

Penicillium chrysogenum

piperidine-6-carboxylic acid and alpha-aminoadipate are precursors for synthesis of alpha-aminoadipate 6-semialdehyde via 3 different pathways, penultimate step in L-lysine biosynthesis

657593

N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O

L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+

9 entries

N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O

L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+

Cryptococcus neoformans

Q6RXX2

enzyme catalyzes the penultimate step in lysine biosynthesis

658579