1.4.99.B3: L-amino acid dehydrogenase (cytochrome b)

This is an abbreviated version!
For detailed information about L-amino acid dehydrogenase (cytochrome b), go to the full flat file.

Word Map on EC 1.4.99.B3

Reaction

an L-amino acid
+
H2O
+ 2 cytochrome b =
an alpha-keto acid
+
NH3
+ 2 reduced cytochrome b

Synonyms

L-amino acid deaminase, LAAD

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.99 With unknown physiological acceptors
                1.4.99.B3 L-amino acid dehydrogenase (cytochrome b)

Crystallization

Crystallization on EC 1.4.99.B3 - L-amino acid dehydrogenase (cytochrome b)

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
the overall fold resembles that of known amine or amino acid oxidases. An additional alpha+beta subdomain is placed close to the putative transmembrane alpha-helix and to the active-site entrance, an FAD isoalloxazine ring is exposed to solvent, and a large and accessible active site suits to bind large hydrophobic substrates. The enzyme requires substrate-induced conformational changes of part of the active site, particularly in Arg316 and Phe318, to achieve the correct geometry for catalysis