1.4.9.2: aralkylamine dehydrogenase (azurin)
This is an abbreviated version!
For detailed information about aralkylamine dehydrogenase (azurin), go to the full flat file.
Word Map on EC 1.4.9.2
-
1.4.9.2
-
methylamine
-
ttq
-
tryptophylquinone
-
quinoproteins
-
tunnel
-
deamination
-
tryptamine
-
half-reaction
-
ttq-dependent
-
alcaligenes
-
benzylamines
-
faecalis
-
breakage
-
h-transfer
-
phenylethylamines
-
deflated
-
structure-reactivity
-
iminoquinone
-
enzyme-catalysed
-
amicyanin
-
semi-classical
-
interprotein
- 1.4.9.2
- methylamine
- ttq
- tryptophylquinone
-
quinoproteins
-
tunnel
-
deamination
- tryptamine
-
half-reaction
-
ttq-dependent
-
alcaligenes
- benzylamines
- faecalis
-
breakage
-
h-transfer
- phenylethylamines
-
deflated
-
structure-reactivity
-
iminoquinone
-
enzyme-catalysed
- amicyanin
-
semi-classical
-
interprotein
Reaction
Synonyms
AADH, AauA, AauB, AMDH, aromatic amine dehydrogenase, dehydrogenase, arylamine, EC 1.4.99.4, quinohemoprotein amine dehydrogenase, tyramine dehydrogenase
ECTree
1.4.9.2 aralkylamine dehydrogenase (azurin)Advanced search results
results (
results (Substrates Products
Substrates Products on EC 1.4.9.2 - aralkylamine dehydrogenase (azurin)
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,3-diaminopropane + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
1,6-diaminohexane + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
2-phenylethylamine + H2O + 2,6-dichlorophenolindophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
-
r
beta-phenylethylamine + acceptor + H2O
? + NH3 + reduced acceptor
-
-
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
beta-phenylethylamine + H2O + 2,6-dichlorophenolindophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenolindophenol
butylamine + H2O + 2,6-dichlorophenol indophenol
butanal + NH3 + reduced 2,6-dichlorophenol indophenol
cadaverine + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
dopamine + H2O + 2,6-dichlorophenol indophenol
(3,4-dihydroxyphenyl)acetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
hexylamine + H2O + 2,6-dichlorophenol indophenol
hexanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
histamine + H2O + 2,6-dichlorophenol indophenol
1H-imidazol-4-ylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
high activity at substrate concentration 1 mM
-
-
?
pentylamine + H2O + 2,6-dichlorophenol indophenol
pentanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenazine ethosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
propylamine + H2O + 2,6-dichlorophenol indophenol
propanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
low activity
-
-
?
putrescine + H2O + 2,6-dichlorophenol indophenol
4-aminobutanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
serotonin + H2O + 2,6-dichlorophenol indophenol
6-hydroxy-4H-indol-3-yl-acetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
spermidine + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
low activity
-
-
?
spermine + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
low activity
-
-
?
tryptamine + H2O + 2,6-dichlorophenol indophenol
4H-indol-3-yl-acetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
tyramine + H2O + 2,6-dichlorophenol indophenol
4-hydroxyphenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
1,3-diaminopropane + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
1,3-diaminopropane + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
1,6-diaminohexane + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
1,6-diaminohexane + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
ArCH2NH2 + H2O + 2 azurin
ArCHO + NH3 + 2 reduced azurin
-
azurin markedly facilitates electron transfer from the enzyme to each cytochrome tested. AADH and azurin may form an electron transfer complex with a c-type cytochrome
-
-
?
ArCH2NH2 + H2O + 2 azurin
ArCHO + NH3 + 2 reduced azurin
-
-
-
-
?
aromatic amines + acceptor + H2O
? + reduced acceptor + NH3
-
physiological acceptor: azurin, not amicyanin
-
-
?
aromatic amines + acceptor + H2O
? + reduced acceptor + NH3
-
specific for phenylethylamines, but also reacts to a lesser extent with primary aliphatic amines
-
-
?
aromatic amines + acceptor + H2O
? + reduced acceptor + NH3
-
physiological acceptor: azurin, not amicyanin
-
-
?
aromatic amines + acceptor + H2O
? + reduced acceptor + NH3
-
specific for phenylethylamines, but also reacts to a lesser extent with primary aliphatic amines
-
-
?
aromatic amines + acceptor + H2O
? + reduced acceptor + NH3
-
catabolism
-
-
?
benzylamine + acceptor + H2O
benzaldehyde + NH3 + reduced acceptor
-
-
-
-
?
benzylamine + acceptor + H2O
benzaldehyde + NH3 + reduced acceptor
-
-
-
-
?
benzylamine + H2O + 2,6-dichlorophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
benzylamine + H2O + 2,6-dichlorophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
analysis of limiting rate constants
-
-
?
benzylamine + H2O + 2,6-dichlorophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenol indophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenolindophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
beta-phenylethylamine + H2O + 2,6-dichlorophenolindophenol
phenylacetaldehyde + NH3 + reduced 2,6-dichlorophenolindophenol
-
-
-
-
?
butylamine + H2O + 2,6-dichlorophenol indophenol
butanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
butylamine + H2O + 2,6-dichlorophenol indophenol
butanal + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
dopamine + acceptor + H2O
4-(2-oxoethyl)-1,2-benzenediol + NH3 + reduced acceptor
-
-
-
-
?
dopamine + acceptor + H2O
4-(2-oxoethyl)-1,2-benzenediol + NH3 + reduced acceptor
-
-
-
-
?
dopamine + acceptor + H2O
4-(2-oxoethyl)-1,2-benzenediol + NH3 + reduced acceptor
-
-
-
-
?
methylamine + acceptor + H2O
formaldehyde + NH3 + reduced acceptor
-
-
-
-
?
methylamine + acceptor + H2O
formaldehyde + NH3 + reduced acceptor
-
-
-
-
?
n-amylamine + H2O + 2 blue protein
? + NH3 + 2 blue protein
-
-
-
?
n-amylamine + H2O + 2 blue protein
? + NH3 + 2 blue protein
-
-
-
?
n-butylamine + H2O + 2 blue protein
butanal + NH3 + 2 blue protein
-
-
-
?
n-butylamine + H2O + 2 blue protein
butanal + NH3 + 2 blue protein
-
-
-
?
phenazine ethosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenazine ethosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenazine methosulfate + H2O + 2,6-dichlorophenol indophenol
? + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
phenylethylamine + acceptor + H2O
phenylacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
phenylethylamine + acceptor + H2O
phenylacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
propylamine + H2O + 2 blue protein
propanal + NH3 + 2 blue protein
the azurin-like blue protein is reduced specifically during AMDH reaction. The amine oxidation system can be reconstituted using AMDH, blue protein, and the cytoplasmic membranes of the organism
-
-
?
propylamine + H2O + 2 blue protein
propanal + NH3 + 2 blue protein
the azurin-like blue protein is reduced specifically during AMDH reaction. The amine oxidation system can be reconstituted using AMDH, blue protein, and the cytoplasmic membranes of the organism
-
-
?
serotonin + acceptor + H2O
3-(2-oxoethyl)-1H-indol-5-ol + NH3 + reduced acceptor
-
-
-
-
?
serotonin + acceptor + H2O
3-(2-oxoethyl)-1H-indol-5-ol + NH3 + reduced acceptor
-
-
-
-
?
serotonin + acceptor + H2O
3-(2-oxoethyl)-1H-indol-5-ol + NH3 + reduced acceptor
-
-
-
-
?
tryptamine + acceptor + H2O
1H-indole-3-acetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tryptamine + acceptor + H2O
1H-indole-3-acetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tryptamine + acceptor + H2O
1H-indole-3-acetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
electron acceptor: azurin
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
electron acceptor: phenazine methosulfate or phenazine ethosulfate
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
electron acceptor: phenazine methosulfate or phenazine ethosulfate
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
electron acceptor: azurin
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tyramine + acceptor + H2O
4-hydroxyphenylacetaldehyde + NH3 + reduced acceptor
-
-
-
-
?
tyramine + H2O + 2,6-dichlorophenol indophenol
4-hydroxyphenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
best substrate
-
-
?
tyramine + H2O + 2,6-dichlorophenol indophenol
4-hydroxyphenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
tyramine + H2O + 2,6-dichlorophenol indophenol
4-hydroxyphenylacetaldehyde + NH3 + reduced 2,6-dichlorophenol indophenol
-
-
-
-
?
additional information
?
-
-
substrate specificity, overview, no activity with methylamine, dimethylamine, and trimethylamine
-
-
?
additional information
?
-
-
substrate specificity, overview, no activity with methylamine, dimethylamine, and trimethylamine
-
-
?
additional information
?
-
-
para-substituted benzylamines like 4-methylbenzylamine, 4-nitrobenzylamine, 4-methoxybenzylamine, 4-fluorobenzylamine, 4-chlorobenzylamine, and 4-bromobenzylamine are poor reactivity probes for AADH
-
-
?
additional information
?
-
-
slow reaction with aromatic amines
-
-
?
additional information
?
-
-
para-substituted benzylamines like 4-methylbenzylamine, 4-nitrobenzylamine, 4-methoxybenzylamine, 4-fluorobenzylamine, 4-chlorobenzylamine, and 4-bromobenzylamine are poor reactivity probes for AADH
-
-
?
additional information
?
-
-
long-chain aliphatic amines, phenazine methosulfate is the only effective electron acceptor
-
-
?
