1.4.9.1: methylamine dehydrogenase (amicyanin)

This is an abbreviated version!
For detailed information about methylamine dehydrogenase (amicyanin), go to the full flat file.

Word Map on EC 1.4.9.1

1.4.9.1

tryptophylquinone

ttq

paracoccus

denitrificans

maug

quinoproteins

diheme

versutus

bis-feiv

protein-derived

methylobacterium

premadh

thiobacillus

davidson

interprotein

extorquens

azurins

quinol

six-electron

substrate-derived

reorganizational

n-methylglutamate

n-butylamine

diferrous

aminoquinols

high-valence

methylomonas

mathews

analysis

Reaction

+ 2 amicyanin =

+ 2 reduced amicyanin

Synonyms

amine dehydrogenase, amine: oxidoreductase (acceptor deaminating), dehydrogenase, amine, EC 1.4.98.1, EC 1.4.99.3, Heme 2, MADH, mauA, methylamine dehydrogenase, primary-amine dehydrogenase, QH-AmDH, QHNDH, quinohaemoprotein amine dehydrogenase, quinohemoprotein amine dehydrogenase, quinohemoprotein amine dehydrogenases, sQH-AmDH

ECTree

1 Oxidoreductases

1.4 Acting on the CH-NH₂ group of donors

1.4.9 With a copper protein as acceptor

1.4.9.1 methylamine dehydrogenase (amicyanin)

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Results	in table
14	Activating Compound
573	AA Sequence
1	Application
2	CAS Registry Number
12	Cloned(Commentary)
38	Cofactor
16	Crystallization (Commentary)
1	Expression
9	General Information
4	General Stability
35	Inhibitors
88	KM Value [mM]
4	Localization
14	Metals/Ions
38	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
104	Organism
4	Pathway
20	PDB ID
9	pH Optimum
1	pH Range
2	pH Stability
7	Posttranslational Modification
20	Protein Variants
20	Purification (Commentary)
5	Reaction
5	Reaction Type
67	Reference
1	Source Tissue
8	Specific Activity [micromol/min/mg]
1	Storage Stability
104	Substrates and Products (Substrate)
26	Subunits
64	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
4	Temperature Stability [°C]
64	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 1.4.9.1 - methylamine dehydrogenase (amicyanin)

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8-hydroxyquinoline

Pseudomonas putida

slight

396576

amicyanin mutant M98K

Paracoccus denitrificans

mutant acts as a competitive inhibitor in the reaction of native amicyanin with methylamine dehydrogenase indicating that the M98K mutation has not affected the affinity for its natural electron donor. The crystal structure of M98K amicyanin reveals an overall structure very similar to native amicyanin but the type I binding site is occupied by zinc instead of copper

Borohydride

Cuprizone

cyclopropylamine

Paracoccus denitrificans

mechanism-based inhibitor. The resulting inactivation is accompanied by the formation of a covalent cross-link between the alpha and beta subunits of the enzyme. No cross-linking is seen with mutant enzymes alphaF55A or alphaF55I mutant enzymes. With mutant enzyme alphaF55E cross-linking of subunits is observed

655553

hydrazine

Paracoccus denitrificans

hydroxylamine

iodoacetate

isoniazid

KCN

n-Butyraldehyde

N-ethylmaleimide

Neocuproine

slight

p-chloromercuribenzoate

2 entries

p-Nitrophenylhydrazine

phenylhydrazine

Quinacrine

Quinine

slight

Semicarbazide

additional information

Pseudomonas sp.

immobilized enzyme: little change in sensitivity to inhibition

396573