1.4.3.4: monoamine oxidase
This is an abbreviated version!
For detailed information about monoamine oxidase, go to the full flat file.
Word Map on EC 1.4.3.4
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1.4.3.4
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dopamine
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antidepressant
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parkinsonism
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platelet
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dopaminergic
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neurotransmitter
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tricyclic
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norepinephrine
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pargyline
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reuptake
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deprenyl
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deamination
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clorgyline
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catecholamine
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noradrenaline
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5-hydroxytryptamine
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neuroprotective
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serotonergic
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striatal
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anxiety
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psychiatric
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l-dopa
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fluoxetine
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catechol-o-methyltransferase
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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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biogenic
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levodopa
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mood
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reserpine
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imipramine
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monoaminergic
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tryptamine
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3,4-dihydroxyphenylacetic
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benzodiazepine
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mpp+
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amphetamine
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nigrostriatal
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homovanillic
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5-hydroxyindoleacetic
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noradrenergic
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dopac
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5-hydroxytryptophan
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1-methyl-4-phenylpyridinium
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paroxetine
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desipramine
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electroconvulsive
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panic
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mptp-induced
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anticholinergic
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antidepressant-like
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drug development
-
analysis
-
synthesis
-
medicine
- 1.4.3.4
- dopamine
-
antidepressant
- parkinsonism
- platelet
-
dopaminergic
-
neurotransmitter
-
tricyclic
- norepinephrine
- pargyline
-
reuptake
- deprenyl
-
deamination
- clorgyline
- catecholamine
- noradrenaline
- 5-hydroxytryptamine
-
neuroprotective
-
serotonergic
- striatal
-
anxiety
-
psychiatric
- l-dopa
- fluoxetine
- catechol-o-methyltransferase
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
biogenic
- levodopa
-
mood
- reserpine
- imipramine
-
monoaminergic
- tryptamine
-
3,4-dihydroxyphenylacetic
- benzodiazepine
- mpp+
- amphetamine
-
nigrostriatal
-
homovanillic
-
5-hydroxyindoleacetic
-
noradrenergic
-
dopac
- 5-hydroxytryptophan
- 1-methyl-4-phenylpyridinium
- paroxetine
- desipramine
-
electroconvulsive
-
panic
-
mptp-induced
-
anticholinergic
-
antidepressant-like
- drug development
- analysis
- synthesis
- medicine
Reaction
Synonyms
adrenaline oxidase, amine-oxygen oxidoreductase, C-MAO, EC 1.4.3.9, epinephrine oxidase, MAO, MAO A, MAO B, MAO type B, MAO-A, MAO-B, MAO-N, MAO-N-D5, MAOA, MAOB, monoamine oxidase, monoamine oxidase A, monoamine oxidase B, monoamine oxidase N, monoamine oxidase type B, monoamine oxidase-A, monoamine oxidase-B, monoamine oxidaseA, monoamine oxidases A, monoamine oxidases B, monoamine-oxidase-A, monoamine: O2-oxidoreductase, deaminated, monoamine: O2-oxidoreductase, deaminating, monoamine: O2-oxidoreductase: deaminating, monoamine:O2 oxidoreductase (deaminating), monoamine:O2 oxidoreductase, deaminating, monoamine:O2-oxidoreductase deaminating, monoaminoxidase B, More, semicarbazide-sensitive amine oxidase, serotonin deaminase, SSAO, tyraminase, tyramine oxidase, zMAO
ECTree
1.4.3.4 monoamine oxidaseAdvanced search results
results (
results (Turnover Number
Turnover Number on EC 1.4.3.4 - monoamine oxidase
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TURNOVER NUMBER [1/s] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.36
(S)-1,2,3,4-tetrahydro-1-methylisoquinoline
mutant enzyme W230I/W430R, pH and temperature not specified in the publication
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0.62
(S)-1,2,3,4-tetrahydro-1-methylisoquinoline
mutant enzyme W230I/T354S/W430R, pH and temperature not specified in the publication
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0.77
(S)-1,2,3,4-tetrahydro-1-methylisoquinoline
mutant enzyme W230I/T354S/W430R/M242R/Y365V, pH and temperature not specified in the publication
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1.03
(S)-1,2,3,4-tetrahydro-1-methylisoquinoline
mutant enzyme W230R/W430C/C214L, pH and temperature not specified in the publication
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0.342
1,2,3,4-tetrahydronaphthalen-1-amine
pH 7.8, 30°C, variant D11
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0.491
1,2,3,4-tetrahydronaphthalen-1-amine
pH 7.8, 30°C, enzyme variant D9
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0.58
1-(4-chlorophenyl)methanamine
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at 25°C in 50 mM potassium phosphate, pH 7.4
0.25
1-(4-fluorophenyl)methanamine
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at 25°C in 50 mM potassium phosphate, pH 7.4
0.14
1-(4-methoxyphenyl)methanamine
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at 25°C in 50 mM potassium phosphate, pH 7.4
0.12
1-(4-methylphenyl)methanamine
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at 25°C in 50 mM potassium phosphate, pH 7.4
0.241
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
pH 7.2, 30°C, wild-type enzyme
0.29
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
pH 7.2, 30°C, mutant enzyme C374A
1.57
1-[4-(trifluoromethyl)phenyl]methanamine
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at 25°C in 50 mM potassium phosphate, pH 7.4
2.882
2,3-dihydro-1H-inden-1-amine
pH 7.8, 30°C, enzyme variant D9
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1.42
2-Phenylethylamine
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
0.325
benzylamine
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
3.8
benzylamine
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mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
5
benzylamine
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wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
1.07
kynuramine
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mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
1.47
kynuramine
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mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
1.6
kynuramine
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
2.48
kynuramine
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
1.83
phenylbutylamine
-
wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
2.25
phenylbutylamine
-
mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
2.34
phenylbutylamine
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
0.998
Phenylethylamine
pH 7.5, MAO-A incorporated into phospholipid nanodisks
1.83
Phenylethylamine
-
mutant enzyme I199A/Y326A, at 25°C in 50 mM phosphate buffer (pH 7.5)
2.05
Phenylethylamine
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mutant enzyme I199A, at 25°C in 50 mM phosphate buffer (pH 7.5)
2.87
Phenylethylamine
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wild type isoform MAO B, at 25°C in 50 mM phosphate buffer (pH 7.5)
5.98
serotonin
isoform MAO A, in 50 mM potassium phosphate assay buffer (pH 7.5), at 25°C
additional information
additional information
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turnover number of MAO-A mutants
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additional information
additional information
kinetic constants for pure hMAO-B oxidising different substrates in the presence of reversible competitive inhibitors or reversible non-competitive/mixed inhibitors
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