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1.4.3.4: monoamine oxidase

This is an abbreviated version!
For detailed information about monoamine oxidase, go to the full flat file.

Word Map on EC 1.4.3.4

Reaction

RCH2NHR'
+
H2O
 +
O2
=
RCHO
 +
R'NH2
 +
H2O2

Synonyms

adrenaline oxidase, amine-oxygen oxidoreductase, C-MAO, EC 1.4.3.9, epinephrine oxidase, MAO, MAO A, MAO B, MAO type B, MAO-A, MAO-B, MAO-N, MAO-N-D5, MAOA, MAOB, monoamine oxidase, monoamine oxidase A, monoamine oxidase B, monoamine oxidase N, monoamine oxidase type B, monoamine oxidase-A, monoamine oxidase-B, monoamine oxidaseA, monoamine oxidases A, monoamine oxidases B, monoamine-oxidase-A, monoamine: O2-oxidoreductase, deaminated, monoamine: O2-oxidoreductase, deaminating, monoamine: O2-oxidoreductase: deaminating, monoamine:O2 oxidoreductase (deaminating), monoamine:O2 oxidoreductase, deaminating, monoamine:O2-oxidoreductase deaminating, monoaminoxidase B, More, semicarbazide-sensitive amine oxidase, serotonin deaminase, SSAO, tyraminase, tyramine oxidase, zMAO

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.4 monoamine oxidase

KI Value

KI Value on EC 1.4.3.4 - monoamine oxidase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.506 - 2.56
(+)-amphetamine
0.00036
(2E)-1-(4-methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]prop-2-en-1-one
at pH 7.4 and 37°C
0.00022
(2E)-1-(4-methoxyphenyl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one
at pH 7.4 and 37°C
0.00028
(2E)-3-(2-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
at pH 7.4 and 37°C
0.002 - 0.00423
(2E)-3-(3-chlorophenyl)-N-(2-methyl-1H-indol-5-yl)prop-2-enamide
0.00035
(2E)-3-(3-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
at pH 7.4 and 37°C
0.00027
(2E)-3-(4-fluorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one
at pH 7.4 and 37°C
0.00801 - 0.175
(2E)-N-(2-methyl-1H-indol-5-yl)-3-phenylprop-2-enamide
0.0013 - 0.0235
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)trideca-2,4,12-trienamide
0.0122 - 0.1
(2S)-amphetamine
0.00106
(3E)-7-hydroxy-3-[(4-methoxyphenyl)methylidene]-2,3-dihydro-4H-1-benzopyran-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.001063 - 0.026622
(4Z)-1-benzyl-4-[(2E)-(1-phenylethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.001606 - 0.011244
(4Z)-1-benzyl-4-[(2E)-(cyclopentylmethylidene)hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00007142 - 0.000293
(4Z)-1-benzyl-4-[(2E)-benzylidenehydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000034 - 0.001356
(4Z)-1-benzyl-4-[(2E)-[(2-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0005343 - 0.006267
(4Z)-1-benzyl-4-[(2E)-[(2-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000062 - 0.00036
(4Z)-1-benzyl-4-[(2E)-[(2-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000716 - 0.005886
(4Z)-1-benzyl-4-[(2E)-[(2-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000131 - 0.000222
(4Z)-1-benzyl-4-[(2E)-[(3-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.011429 - 0.030444
(4Z)-1-benzyl-4-[(2E)-[(3-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000054 - 0.000066
(4Z)-1-benzyl-4-[(2E)-[(4-bromophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00006285 - 0.00008
(4Z)-1-benzyl-4-[(2E)-[(4-chlorophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000138 - 0.0007371
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxy-3-methoxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00014 - 0.000951
(4Z)-1-benzyl-4-[(2E)-[(4-hydroxyphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000126 - 0.000613
(4Z)-1-benzyl-4-[(2E)-[(4-methylphenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.00038 - 0.000453
(4Z)-1-benzyl-4-[(2E)-[(4-nitrophenyl)methylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000062 - 0.011429
(4Z)-1-benzyl-4-[(2E)-[1-(2,4-dichlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000306 - 0.033956
(4Z)-1-benzyl-4-[(2E)-[1-(4-chlorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000284 - 0.008543
(4Z)-1-benzyl-4-[(2E)-[1-(4-fluorophenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0018622 - 0.012657
(4Z)-1-benzyl-4-[(2E)-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0114 - 0.025244
(4Z)-1-benzyl-4-[(2E)-[1-(furan-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000154 - 0.021822
(4Z)-1-benzyl-4-[(2E)-[1-(pyridin-2-yl)ethylidene]hydrazinylidene]-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.000058 - 0.004429
(4Z)-4-[(2E)-[1-(2-aminophenyl)ethylidene]hydrazinylidene]-1-benzyl-3,4-dihydro-2lambda6,1-benzothiazine-2,2(1H)-dione
-
0.0012
(5R)-3-(3-fluoro-4-morpholin-4-ylphenyl)-5-(hydroxymethyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.00016
(5R)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.00034
(5R)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-5-(hydroxymethyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.116
(5S)-5-(aminomethyl)-3-(3-fluoro-4-morpholin-4-ylphenyl)-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.0057
(5S)-5-(aminomethyl)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.023
(5S)-5-(aminomethyl)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-1,3-oxazolidin-2-one
pH 7.2, 30°C
0.00256 - 0.00378
(6-benzyloxy-2-naphthyl)-2-aminopropane
0.00153
(6-butoxy-2-naphthyl)-2-aminopropane
MAO-A
0.00045 - 0.0163
(6-ethoxy-2-naphthyl)-2-aminopropane
0.00018 - 0.1
(6-methoxy-2-naphthyl)-2-aminopropane
0.0005
(6-methylthio-2-naphthyl)isopropylamine
MAO-A
0.00068 - 0.0136
(6-propoxy-2-naphthyl)-2-aminopropane
0.00179
(E)-3-(2-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.01973
(E)-3-(3,4-dimethoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0022
(E)-3-(3-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00103
(E)-3-(4-(dimethylamino)benzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0154
(E)-3-(4-chlorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00109
(E)-3-(4-fluorobenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00343
(E)-3-(4-methoxybenzylidene)-7-(10-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00116
(E)-3-(4-methoxybenzylidene)-7-(5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.000401
(E)-3-(4-methoxybenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.000518
(E)-3-(4-methoxybenzylidene)-7-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.000437
(E)-3-(4-methoxybenzylidene)-7-(9-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00124
(E)-3-(4-methylbenzylidene)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00019 - 0.001
(E)-3-chlorocinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.0014 - 0.0125
(E)-5-(3-chlorostyryl)isatin
0.00056 - 0.022
(E)-5-(3-fluorostyryl)isatin
0.00031 - 0.0011
(E)-5-styrylisatin
0.0006 - 0.0045
(E)-6-styrylisatin
0.00136
(E)-7-(6-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)-3-(4-methoxybenzylidene)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.00156
(E)-7-(8-(6-chloro-1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)3-(4-methoxybenzylidene)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0397
(E)-8-(2-furylethenyl)caffeine
-
-
0.00158
(E)-8-(2-thienylethenyl)caffeine
-
-
0.000036
(E)-8-(3,4-dichlorostyryl)caffeine
-
-
0.000239
(E)-8-(3,5-ditrifluoromethylstyryl)caffeine
-
-
0.000083
(E)-8-(3-bromostyryl)caffeine
-
-
0.00003 - 0.000148
(E)-8-(3-chlorostyryl)caffeine
0.001431
(E)-8-(3-methylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000133
(E)-8-(3-trifluoromethylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.00026
(E)-8-(4-chlorostyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.001559
(E)-8-(4-fluorostyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000367
(E)-8-(4-methylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000245
(E)-8-(4-trifluoromethylstyryl)caffeine
-
with 1-methyl-4-(1-methylpyrrol-2-yl)1,2,3,6-tetrahydropyridine as substrate
0.000094 - 0.00286
(E)-8-styrylcaffeine
MAO-B
0.00052 - 0.0033
(E)-cinnamic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
1.4 - 2.7
(N-cyclopropyl-alpha-methylbenzylamine)
0.0000017 - 0.00003
(R)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
0.00026 - 0.0015
(R)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
0.00002 - 0.007
(R)-N-(alpha-cyclohexylethyl)-N-methyl,N-(pyrrol-2-ylmethyl)-amine
0.00122 - 0.0025
(R,S)-N-(alpha-phenylethyl)-1H-pyrrole-2-carboxamide
0.0001 - 0.0045
(R,S)-N-methyl,N-(alpha-phenylethyl),N-(pyrrol-2-ylmethyl)-amine
0.00001 - 0.0618
(R,S)-N-methyl,N-(alpha-phenylethyl)-1H-pyrrole- 2-carboxamide
0.00002 - 0.0041
(S)-N-(alpha-cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide
0.00033 - 0.0036
(S)-N-(alpha-cyclohexylethyl)-1H-pyrrole-2-carboxamide
0.000051 - 0.0013
1,3,7-trimethyl-8-([3-(trifluoromethyl)benzyl]oxy)-3,7-dihydro-1H-purine-2,6-dione
0.00014 - 0.0004
1,3,7-trimethyl-8-[(3-methylbenzyl)oxy]-3,7-dihydro-1H-purine-2,6-dione
0.0113
1,3,7-trimethyl-8-[(E)-2-(3-thienyl)vinyl]-3,7-dihydro-1H-purine-2,6-dione
-
-
0.001 - 0.007
1,4-diphenyl-1,3-butadiene
0.0007 - 0.0345
1,4-diphenyl-2-butene
0.0056 - 0.1
1-(1-naphthyl)-2-aminopropane
0.00042 - 0.1
1-(2-naphthyl)-2-aminopropane
0.00071 - 0.00342
1-(4-benzyloxyphenyl)-2-aminopropane
0.00032 - 0.1
1-(4-butoxyphenyl)-2-aminopropane
0.00022 - 0.1
1-(4-ethoxyphenyl)-2-aminopropane
0.00025
1-(4-methoxy-phenyl)-2-aminopropane
MAO-A
0.00025
1-(4-methylthiophenyl)-2-aminopropane
MAO-A
0.00013 - 0.1
1-(4-propoxyphenyl)-2-aminopropane
0.0417
1-methoxy-3-(3-methylphenyl)pyrrole
-
pH 7.4, 37°C
0.00326
1-methyl-2-[(E)-2-(4-methylphenyl)vinyl]-1H-benzimidazole
-
-
0.0187
1-methyl-2-[(E)-2-phenylvinyl]-1H-benzimidazole
-
-
0.00043
1-methyl-2-[(E)-2-[4-(trifluoromethyl)phenyl]vinyl]-1H-benzimidazole
-
-
0.0143
1-methyl-3-(3-bromophenyl)pyrrole
-
pH 7.4, 37°C
0.0209
1-methyl-3-(3-chlorophenyl)pyrrole
-
pH 7.4, 37°C
0.0389
1-methyl-3-(3-fluorophenyl)pyrrole
-
pH 7.4, 37°C
0.056
1-methyl-3-(3-methylphenyl)-1H-pyrrole
-
pH 7.4, 37°C
0.056
1-methyl-3-(3-methylphenyl)pyrrole
-
pH 7.4, 37°C
0.0066
1-methyl-3-(3-trifluoromethylphenyl)pyrrole
-
pH 7.4, 37°C
0.0225
1-methyl-3-(4-methylphenyl)-1H-pyrrole
-
pH 7.4, 37°C
0.118
1-methyl-3-phenyl-1H-pyrrole
-
pH 7.4, 37°C
0.118
1-methyl-3-phenylpyrrole
-
pH 7.4, 37°C
0.0013
1-methyl-3-[4-(trifluoromethyl)phenyl]-1H-pyrrole
-
pH 7.4, 37°C
0.182
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
-
0.0035 - 0.0045
1-methyl-4-phenylpyridinium
0.0055 - 0.0399
1-methyl-N-(2-methyl-1H-indol-5-yl)-1lambda4-pyridine-3-carboxamide
0.0333
1-N-allylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.0337
1-N-allylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, MAO-B, selective for MAO-B
0.0269
1-N-ethylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.024
1-N-ethylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, MAO-B, selective for MAO-B
0.013
1-N-methylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.0125
1-N-methylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-B
0.0608
1-N-phenylthiocarbamoyl-3-(4-chlorophenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, selective for MAO-A, no preincubation
0.0371
1-N-phenylthiocarbamoyl-3-(4-methoxyphenyl)-5-(2-pyrrolyl)-4,5-dihydro-(1H)-pyrazole
pH 7.6, 37°C, MAO-B, selective for MAO-B
0.0122
1-phenyl-2-aminopropane
MAO-A
7.3 - 12.8
1-phenylcyclopropylamine
0.00789 - 0.326
2-(2-benzofuranyl)-2-imidazoline
0.000048 - 0.1
2-(4'-benzyloxyphenyl)thiomorpholin-5-one
0.000038 - 0.1
2-(4'-benzyloxyphenyl)thiomorpholine oxalate
0.00016 - 0.0509
2-(4'-butoxyphenyl)thiomorpholin-5-one
0.000068 - 0.0141
2-(4'-butoxyphenyl)thiomorpholine oxalate
0.0034 - 0.06
2-(4'-ethoxyphenyl)thiomorpholin-5-one
0.0021 - 0.0096
2-(4'-ethoxyphenyl)thiomorpholine oxalate
0.00928 - 0.1
2-(4'-methoxyphenyl)thiomorpholin-5-one
0.0039 - 0.1
2-(4'-methoxyphenyl)thiomorpholine oxalate
0.0015 - 0.04
2-(4'-propoxyphenyl)thiomorpholin-5-one
0.00013 - 0.0066
2-(4'-propoxyphenyl)thiomorpholine oxalate
0.0652 - 0.513
2-(4,5-dihydroimidazol-2-yl)-isoquinoline
0.0817 - 0.385
2-(4,5-dihydroimidazol-2-yl)-quinoline
0.0329
2-(4-bromophenyl)cyclopropanamine
inhibition of MAO-B
0.0866
2-(4-methoxyphenyl)cyclopropanamine
inhibition of MAO-B
0.008 - 0.114
2-(5,7-dibromobenzofuran-2-yl)-imidazoline
0.0098
2-(naphthalen-1-yl)cyclopropanamine
inhibition of MAO-B
1.548
2-(thiophen-3-yl)cyclopropanamine
inhibition of MAO-B
0.25
2-hydroxyquinoline
-
-
0.2 - 0.31
2-phenylcyclopropylamine
0.00919 - 0.1
2-phenylthiomorpholin-5-one
0.0022 - 0.1
2-phenylthiomorpholine oxalate
0.000104
2-[(1E,3E)-4-(3-chlorophenyl)buta-1,3-dien-1-yl]-3,5,7-trimethyl-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
MAO-B
0.00254
2-[(E)-2-(4-bromophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.00283
2-[(E)-2-(4-chlorophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.01495
2-[(E)-2-(4-fluorophenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.00582
2-[(E)-2-(4-methoxyphenyl)vinyl]-1-methyl-1H-benzimidazole
-
-
0.0077
2-[4-(trifluoromethyl)phenyl]cyclopropanamine
inhibition of MAO-B
0.00003 - 0.0026
3,4-dichloro-N-(2-methyl-1H-indol-5-yl)benzamide
0.000149 - 0.000153
3,5,7-trimethyl-2-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
MAO-B
0.000006 - 0.00001
3,5-bis(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000027 - 0.00005
3,5-di-2-thienyl-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0143
3-(3-bromophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0209
3-(3-chlorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0389
3-(3-fluorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0417
3-(3-methoxyphenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.00655
3-(3-tert-butylphenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.00665
3-(4-bromophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.0184
3-(4-chlorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.031
3-(4-fluorophenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.000008 - 0.00037
3-(4-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000007 - 0.00005
3-(4-fluorophenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.00111
3-(4-methoxybenzyl)-7-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyloxy)chroman-4-one
isoform MAO-B, at pH 8.0 and 37°C
0.0365
3-(4-methoxyphenyl)-1-methyl-1H-pyrrole
-
pH 7.4, 37°C
0.00033 - 0.0082
3-chloro-N-(2-methyl-1H-indol-5-yl)benzamide
0.00043 - 0.002
3-chlorobenzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.0683 - 0.0757
3-[(2-methyl-1H-indol-5-yl)carbamoyl]benzene-1-sulfonic acid
0.00000274
5,7-diethyl-3-methyl-2-[(1E,3E)-4-phenylbuta-1,3-dien-1-yl]-3H-imidazo[4,5-c]pyridine-4,6(5H,7H)-dione
MAO-B
0.00002 - 0.00005
5-(2-furyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000004 - 0.00017
5-(2-furyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000006 - 0.000041
5-(4-chlorophenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000006 - 0.001
5-(4-chlorophenyl)-3-(4-fluorophenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.0000015 - 0.000031
5-(4-chlorophenyl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.00001 - 0.00005
5-(4-methylphenyl)-3-(2-thienyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide
0.000032
5-fluoro-alpha-methyltryptamine
-
-
0.000102
5-nitroindazole
-
pH 7.4, 37°C, MAO-B
2.823
6-(3-chlorophenyl)-1,3-dimethyl-1H-pteridine-2,4-dione
-
pH 7.4, 37°C
6.958
6-amino-1,3-dimethyl-5-[(E)-3-phenyl-prop-2-en-(E)-ylideneamino]-1H-pyrimidine-2,4-dione
-
pH 7.4, 37°C
4.06
6-amino-5-([1-(3-chlorophenyl)-meth-(E)-ylidene]-amino)-1,3-dimethyl-1H-pyrimidine-2,4-dione
-
pH 7.4, 37°C
0.348
6-amino-5-[(E)-3-(3-chloro-phenyl)-prop-2-en-(E)-ylideneamino]-1,3-dimethyl-1H-pyrimidine-2,4-dione
-
pH 7.4, 37°C
0.0016
6-fluoro-alpha-methyltryptamine
-
-
0.00067
6-nitroindazole
-
pH 7.4, 37°C, MAO-B
0.181
6-[(E)-2-(3-chlorostyryl)]-1,3-dimethyl-1H-pteridine-2,4-dione
-
pH 7.4, 37°C
0.0001 - 0.0157
7-(3-chlorobenzyloxy)-4-(methylamino)methylcoumarin
0.0004 - 0.011
7-(3-chlorobenzyloxy)-4-carboxaldehydecoumarin
0.0074
7-nitroindazole
-
pH 7.4, 37°C, MAO-B
0.00027 - 0.0017
8-(3-chloro)styrylcaffeine
0.0024
8-(3-chlorostyryl)-caffeine
-
at 25°C in 50 mM potassium phosphate, pH 7.4
0.0002 - 0.0014
8-(3-chlorostyryl)caffeine
0.00043 - 0.00144
8-(benzyloxy)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.65
8-hydroxyquinoline
-
-
0.000023 - 0.00033
8-[(3-bromobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.000036 - 0.00023
8-[(3-chlorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00018 - 0.00037
8-[(3-fluorobenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.00034 - 0.0011
8-[(3-methoxybenzyl)oxy]-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione
0.0399
9,11-dimethylpurino[7,8-c]quinazoline-8,10(9H,11H)-dione
-
-
0.2
alpha-Naphthol
-
-
0.0177 - 0.55
amitriptyline
0.02
amphetamine
-
-
0.0000026
Azure Blue
pH and temperature not specified in the publication
-
0.003
benzaldehyde
-
at pH 7.0 and 37°C
0.00305 - 0.00383
benzoic acid 2-oxo-2,3-dihydro-benzofuran-5-yl ester
0.026 - 2.096
benzylhydrazine
0.1
beta-naphthol
-
-
0.022
Caffeine
MAO-B
0.00000128 - 0.058
Clorgyline
0.027267
clorogyline
pH and temperature not specified in the publication
-
0.0204 - 0.0586
cyanidin
0.0474 - 0.0611
cyanidin-3-O-beta-D-glucoside
0.006 - 6
D-amphetamine
0.0000087 - 0.0019214
Deprenyl
0.00298 - 0.0799
di(2-hydroxyethyl)methyldodecylammonium
0.026 - 0.211
eugenol
0.0023 - 0.018
farnesol
0.00005554 - 0.00013
harman
0.00075 - 0.55
Harmane
0.000005
harmine
pH and temperature not specified in the publication
0.0015 - 10
isatin
0.0000022 - 0.0000045
KW-6002
MAO-B
0.017 - 0.297
metamphetamine
-
0.0013 - 0.0235
methyl (2E,4E)-5-(1,3-benzodioxol-5-yl)penta-2,4-dienoate
0.000004 - 0.00101
methylene blue
0.00145 - 0.2
moclobemide
0.000028 - 0.0011
mofegiline
0.022 - 0.212
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-2-(4-[[methyl(prop-2-yn-1-yl)amino]methyl]phenyl)acetamide
0.268
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-3-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide
inhibition of MAO-A
0.015
N-(1-hydroxy-2,2,6,6-tetramethylpiperidin-4-yl)-4-[[methyl(prop-2-yn-1-yl)amino]methyl]benzamide
inhibition of MAO-B
0.00002 - 0.000024
N-(2-benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
0.00165 - 0.0395
N-(2-methyl-1H-indol-5-yl)benzamide
0.003 - 0.0183
N-(2-methyl-1H-indol-5-yl)cyclohexanecarboxamide
0.00002 - 0.085
N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
0.000007 - 0.00012
N-(2-phenylethyl),N-methyl-1H-pyrrole-2-carboxamide
0.000055
N-(3',4'-dimethylphenyl)-4-oxo-4H-chromene-3-carboxamide
pH 7.5, 25°C
-
0.000017
N-(3'-chlorophenyl)-4-oxo-4H-chromene-3-carboxamide
pH 7.5, 25°C
-
0.000031
N-(3'-fluorophenyl)-4-oxo-4H-chromene-3-carboxamide
pH 7.5, 25°C
-
0.00004 - 0.0089
N-(3-phenylpropyl),N-methyl-1H-pyrrole-2-carboxamide
0.0007 - 0.025
N-(3-phenylpropyl)-1H-pyrrole-2-carboxamide
0.1
N-(4-benzyloxybenzyl)-4-methylthioamphetamine
MAO-A
0.009
N-(4-butoxybenzyl)-4-methylthioamphetamine
MAO-A
0.1
N-(4-hydroxybenzyl)-4-methylthioamphetamine
-
0.1
N-(4-methoxybenzyl)-4-methylthioamphetamine
MAO-A
0.00009 - 0.0025
N-(4-phenylbutyl),N-methyl 1H-pyrrole-2-carboxamide
0.000055 - 0.057
N-(4-phenylbutyl)-1H-pyrrole-2-carboxamide
0.00035 - 0.0072
N-(benzyl),N-(pyrrol-2-ylmethyl)amine
0.0003 - 0.00062
N-(propargyl),N-(pyrrol-2-ylmethyl)amine
0.0016
N-([(5S)-3-[3-fluoro-4-(4-pyrazin-2-ylpiperazin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
pH 7.2, 30°C
0.005
N-([(5S)-3-[4-(4-bromo-1H-imidazol-1-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl)acetamide
pH 7.2, 30°C
0.00042
N-2-phenylethyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.0006 - 0.15
N-benzyl,N-methyl-1H-pyrrole-2-carboxamide
0.1
N-benzyl-(4-methylthioamphetamine)
-
0.0145 - 0.0222
N-benzyl-(6-butoxy-2-naphthyl)-2-aminopropane
0.00693 - 0.0247
N-benzyl-(6-methoxy-2-naphthyl)-2-aminopropane
0.00025 - 0.15
N-benzyl-1H-pyrrole-2-carboxamide
0.00856
N-methoxy-2-(3-methylphenyl)maleimide
-
pH 7.4, 37°C
0.00005 - 0.0007
N-methyl,N-(2-phenylethyl),N-(pyrrol-2-ylmethyl)amine
0.0001 - 0.002
N-methyl,N-(3-phenylbutyl),N-(pyrrol-2-ylmethyl)amine
0.00005 - 0.0048
N-methyl,N-(3-phenylpropyl),N-(pyrrol-2-ylmethyl)amine
0.00015 - 0.3
N-methyl,N-(benzyl),N-(1-methylpyrrol-2-ylmethyl)amine
0.00002 - 0.0035
N-methyl,N-(benzyl),N-(pyrrol-2-ylmethyl)amine
0.00044
N-methyl,N-(propargyl),N-(1-methylpyrrol-2-ylmethyl)-amine
pH 7.4, 38°C
0.00699
N-methyl-2-(3-bromophenyl)maleimide
-
pH 7.4, 37°C
0.00666
N-methyl-2-(3-chlorophenyl)maleimide
-
pH 7.4, 37°C
0.00573
N-methyl-2-(3-fluorophenyl)maleimide
-
pH 7.4, 37°C
0.086
N-methyl-2-(3-methylphenyl)maleimide
-
pH 7.4, 37°C
0.011
N-methyl-2-(3-trifluoromethylphenyl)maleimide
-
pH 7.4, 37°C
0.00349
N-methyl-2-phenylmaleimide
-
pH 7.4, 37°C
0.0004
N-phenyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00083
N-propargyl,N-methyl-1-methyl-1H-pyrrole-2-carboxamide
pH 7.4, 38°C
0.00023 - 0.07
N-propargyl-1H-pyrrole-2-carboxamide
0.02
N-[[(5S)-3-(3-fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
pH 7.2, 30°C
0.00112 - 0.0012
norharman
0.000011 - 0.00003
p-(propylthio)-phenylisopropylamine
0.0053
Pargyline
-
0.00004 - 0.00245
pheniprazine
0.127 - 625
phentermine
0.015 - 0.128
Phenylethylhydrazine
0.205 - 0.791
phenylhydrazine
0.00077 - 0.0024
pirlindole mesylate
0.0033 - 0.0256
rasagiline
0.000021 - 0.365
safinamide
0.000055 - 0.0038
selegiline
0.000009
tetrindole
pH and temperature not specified in the publication
0.0036 - 0.0341
tetrindole mesylate
0.0023
trans,trans-farnesol
monoamine oxidase B
0.0136 - 0.0373
trans-2-phenylcyclopropylamine
0.007
trans-trans-1,4-diphenyl-1,3-butadiene
-
-
0.0038 - 0.017
tranylcypromine
0.00049
ZnSO4
-
monoamine oxidase A
additional information
additional information
-