1.4.3.3: D-amino-acid oxidase

This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.3

Reaction

a D-amino acid
+
H2O
+
O2
=
a 2-oxo carboxylate
+
NH3
+
H2O2

Synonyms

chDAO, D-AAO, D-amino acid oxidase, D-amino acid oxidases, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO,  LH99

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.3 D-amino-acid oxidase

Substrates Products

Substrates Products on EC 1.4.3.3 - D-amino-acid oxidase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3,4-dihydroxy-D-phenylalanine + H2O + O2
3,4-dihydroxyphenylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
4-fluoro-D-Phe + H2O + O2
4-fluorophenylpyruvate + NH3 + H2O2
show the reaction diagram
82% activity compared to D-Met
-
-
?
4-fluoro-DL-phenylalanine + H2O + O2
4-fluoro-phenylpyruvate + NH3 + H2O2
show the reaction diagram
Q7X2D3
81% activity compared to D-methionine
-
-
?
a D-amino acid + H2O + O2
a 2-oxo acid + NH3 + H2O2
show the reaction diagram
alanine + H2O + O2
pyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
cephalosporin C
alpha-ketoadipinyl-7-aminocephalosporanic acid
show the reaction diagram
-
-
-
-
-
cephalosporin C + H2O + O2
7-(5-oxoadipoamido)cephalosporanic acid + NH3 + H2O2
show the reaction diagram
cephalosporin C + H2O + O2
7-aminocephalosporanic acid + ? + H2O2
show the reaction diagram
-
conversion of cephalosporin C to 7-aminocephalosporanic acid and spontaneous decarboxylation of oxoadipyl-7-amino cephalosporanic acid is promoted by the H2O2 formed in the oxidase reaction of TvDAO
-
-
?
cephalosporin C + H2O + O2
7-aminocephalosporanic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
ir
D-1-naphthyl-alanine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-1-naphthyl-glycine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-2-aminobutyrate + H2O + O2
2-oxobutyrate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-2-chloro-phenylglycine + H2O + O2
(2-chlorophenyl)acetic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-2-fluoro-phenylglycine + H2O + O2
(2-fluorophenyl)acetic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-2-naphthyl-alanine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-2-naphthyl-glycine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-3,4-dihydroxyphenylalanine + H2O + O2
?
show the reaction diagram
D-3,4-dihydroxyphenylalanine + H2O + O2
? + H2O2 + NH3
show the reaction diagram
D-4-chloro-phenylglycine + H2O + O2
(4-chlorophenyl)acetic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-4-fluoro-phenylglycine + H2O + O2
(4-fluorophenyl)acetic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-4-hydroxy-phenylglycine + H2O + O2
(4-hydroxyphenyl)acetic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-Ala + H2O + O2
pyruvate + + NH3 + H2O2
show the reaction diagram
D-Ala + H2O + O2
pyruvate + NH3 + H2O2
show the reaction diagram
D-alanine + H2O + O2
pyruvate + H2O2 + NH3
show the reaction diagram
-
-
-
-
?
D-alanine + H2O + O2
pyruvate + NH3 + H2O2
show the reaction diagram
D-alanine + H2O + O2
pyruvic acid + NH3 + H2O2
show the reaction diagram
D-allo-isoleucine + H2O + O2
?
show the reaction diagram
Q7X2D3
1.0% activity compared to D-methionine
-
-
?
D-alpha-aminoadipate + H2O + O2
2-oxoadipate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-amino acid + H2O + O2
2-oxo acid + NH3 + H2O2
show the reaction diagram
D-amino acid + H2O + O2
2-oxocarboxylate + NH3 + H2O2
show the reaction diagram
D-amino acid + H2O + O2
a 2-oxo carboxylate + NH3 + H2O2
show the reaction diagram
-
-
-
-
ir
D-Arg + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-Arg + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
D-arginine + H2O + O2
5-guanidino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-arginine + H2O + O2
5-guanidino-2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
D-Asn + H2O + O2
2-oxosuccinamate + NH3 + H2O2
show the reaction diagram
D-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
show the reaction diagram
D-asparagine + H2O + O2
2-oxosuccinamic acid + NH3 + H2O2
show the reaction diagram
D-aspartate + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-aspartate + H2O + O2
? + NH3 + H2O2
show the reaction diagram
recombinant maltose-binding protein-fusion DAAO
-
-
?
D-aspartate + H2O + O2
oxaloacetate + NH3 + H2O2
show the reaction diagram
D-aspartic acid + H2O + O2
oxaloacetate + NH3 + H2O2
show the reaction diagram
-
weak activity
-
-
?
D-citrulline + H2O + O2
2-oxo-5-ureidopentanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-Cys + H2O + O2
2-oxo-3-thiopropionate + NH3 + H2O2
show the reaction diagram
-
1% of the activity with D-Met
-
-
?
D-cysteine + H2O + O2
2-oxo-3-thiopropionic acid + NH3 + H2O2
show the reaction diagram
D-DOPA + H2O + O2
3,4-dihydroxyphenylpyruvic acid + NH3 + H2O2
show the reaction diagram
D-ethionine + H2O + O2
4-ethylsulfanyl-2-oxobutyric acid + NH3 + H2O2
show the reaction diagram
D-Gln + H2O + O2
2-oxoglutaramate + NH3 + H2O2
show the reaction diagram
D-Glu + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
show the reaction diagram
D-glufosinate + H2O + O2
?
show the reaction diagram
-
-
-
-
ir
D-glutamate + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
show the reaction diagram
D-glutamic acid + H2O + O2
alpha-ketoglutarate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-glutamine + H2O + O2
2-oxoglutaramate + NH3 + H2O2
show the reaction diagram
D-His + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoic acid + NH3 + H2O2
show the reaction diagram
D-histidine + H2O + O2
3-(1H-imidazol-4-yl)-2-oxopropanoate + NH3 + H2O2
show the reaction diagram
D-homo-phenylalanine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-Ile + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-isoleucine + H2O + O2
3-methyl-2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
D-kynurenine + H2O + O2
kynurenic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-kynurenine + NH3 + H2O2
kynurenic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
-
D-Leu + H2O + O2
3-methyl-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-Leu + H2O + O2
4-methyl-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-Leu + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-leucine + H2O + O2
4-methyl-2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
D-Lys + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
show the reaction diagram
D-Lys + H2O + O2
?
show the reaction diagram
D-Lys + H2O + O2
? + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-lysine + H2O + O2
6-amino-2-oxohexanoic acid + NH3 + H2O2
show the reaction diagram
D-Met + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
D-Met + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
show the reaction diagram
-
best substrate
-
-
?
D-methionine + 2,6-dichloroindophenol
4-methylsulfanyl-2-oxobutanoate + reduced 2,6-dichloroindophenol
show the reaction diagram
D-methionine + 2,6-dichlorophenolindophenol
?
show the reaction diagram
-
-
-
-
?
D-methionine + 2,6-dichlorophenolindophenol + H2O
?
show the reaction diagram
-
-
-
-
?
D-methionine + H2O + 2,6-dichloroindophenol
?
show the reaction diagram
-
-
-
-
?
D-methionine + H2O + O2
2-oxo-4-methylthiobutyric acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
ir
D-methionine + H2O + O2
4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
D-methionine + H2O + O2
4-methylthio-2-oxobutanoate + NH3 + H2O2
show the reaction diagram
-
highly active
-
-
?
D-methionine + H2O + O2
4-methylthio-2-oxobutanoic acid + NH3 + H2O2
show the reaction diagram
D-naphthylalanine + H2O + O2
naphthylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-norleucine + H2O + O2
2-oxohexanoate + NH3 + H2O2
show the reaction diagram
D-norvaline + H2O + O2
2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-Orn + H2O + O2
5-amino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
34% activity compared to D-Met
-
-
?
D-ornithine + H2O + O2
5-amino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-Phe + H2O + O2
phenylpyruvate + NH3 + H2O2
show the reaction diagram
D-phenylalanine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-phenylalanine + H2O + O2
phenylpyruvate + NH3 + H2O2
show the reaction diagram
D-phenylalanine + H2O + O2
phenylpyruvic acid + NH3 + H2O2
show the reaction diagram
D-phenylglycine + H2O + O2
benzoylformic acid + NH3 + H2O2
show the reaction diagram
D-Pro + H2O + O2
2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-Pro + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
D-proline + H2O + O2
2-oxopentanoate + NH3 + H2O2
show the reaction diagram
D-proline + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
D-Ser + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
show the reaction diagram
D-Ser + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-serine + H2O + O2
2-oxo-3-hydroxypropionate + NH3 + H2O2
show the reaction diagram
D-serine + H2O + O2
2-oxo-3-hydroxypropionic acid + NH3 + H2O2
show the reaction diagram
D-serine + H2O + O2
3-hydroxypyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-serine + H2O + O2
?
show the reaction diagram
-
-
-
-
?
D-serine + H2O + O2
? + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-Thr + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
show the reaction diagram
D-threonine + H2O + O2
2-oxo-3-hydroxybutyrate + NH3 + H2O2
show the reaction diagram
D-threonine + H2O + O2
2-oxo-3-hydroxybutyric acid + NH3 + H2O2
show the reaction diagram
D-Trp + H2O + O2
indol-3-pyruvate + NH3 + H2O2
show the reaction diagram
D-Trp + H2O + O2
indole-3-pyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
D-tryptophan + H2O + O2
indol-3-pyruvate + NH3 + H2O2
show the reaction diagram
D-tryptophan + H2O + O2
indol-3-pyruvic acid + NH3 + H2O2
show the reaction diagram
D-tryptophan + H2O + O2
indole-3-pyruvic acid + NH3 + H2O2
show the reaction diagram
D-Tyr + H2O + O2
4-hydroxyphenylpyruvate + NH3 + H2O2
show the reaction diagram
D-Tyr + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
show the reaction diagram
D-tyrosine + H2O + O2
4-hydroxyphenylpyruvic acid + NH3 + H2O2
show the reaction diagram
D-Val + H2O + O2
2-oxoisovalerate + NH3 + H2O2
show the reaction diagram
D-Val + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
show the reaction diagram
D-valine + H2O + O2
alpha-ketoisovalerate + NH3 + H2O2
show the reaction diagram
-
highly active
-
-
?
D-valine + H2O + O2
alpha-ketoisovaleric acid + NH3 + H2O2
show the reaction diagram
DL-2-naphthyl-alanine + H2O + O2
L-2-naphthyl-alanine + 2-naphthylpyruvic acid + NH3 + H2O2
show the reaction diagram
-
-
-
-
ir
DL-homophenylalanine + H2O + O2
homophenylpyruvate + NH3 + H2O2
show the reaction diagram
Q7X2D3
31% activity compared to D-methionine
-
-
?
DL-tert-leucine + H2O + O2
?
show the reaction diagram
Q7X2D3
0.12% activity compared to D-methionine
-
-
?
epsilon-N-benzoyl-D-lysine + H2O + O2
6-benzylamino-2-oxohexanoate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
Gly + H2O + O2
acetate + NH3 + H2O2
show the reaction diagram
glycine + 2 H2O + O2
2 formic acid + NH3 + H2O2
show the reaction diagram
glycine + H2O + O2
glyoxylate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
glyphosate + H2O + O2
?
show the reaction diagram
-
-
-
-
?
L-Ala + H2O + O2
pyruvate + NH3 + H2O2
show the reaction diagram
-
low activity
-
-
?
L-Asp + H2O + O2
oxaloacetate + NH3 + H2O2
show the reaction diagram
-
low activity
-
-
?
L-DOPA + H2O + O2
3,4-dihydroxyphenylpyruvate + NH3 + H2O2
show the reaction diagram
-
-
-
-
?
L-Pro + H2O + O2
2-oxopentanoic acid + NH3 + H2O2
show the reaction diagram
-
low activity
-
-
?
N-acetyl-D-alanine + H2O + O2
pyruvate + aminoacetate + H2O2
show the reaction diagram
-
-
-
-
?
N-methyl-D-aspartate + H2O + O2
?
show the reaction diagram
wild-type enzyme shows no activity, mutant enzyme M213R is active
-
-
?
N-methyl-DL-Leu + H2O + O2
4-methyl-2-oxopentanoate + methylamine + H2O2
show the reaction diagram
5.8% activity compared to D-Met
-
-
?
N-methyl-DL-leucine + H2O + O2
?
show the reaction diagram
Q7X2D3
2.1% activity compared to D-methionine
-
-
?
O-methyl-DL-serine + H2O + O2
?
show the reaction diagram
Q7X2D3
0.33% activity compared to D-methionine
-
-
?
phenylglycine + H2O + O2
benzoylformic acid + NH3 + H2O2
show the reaction diagram
thiazolidine-2-carboxylic acid + H2O + O2
? + NH3 + H2O2
show the reaction diagram
additional information
?
-