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1.4.3.3: D-amino-acid oxidase

This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.3

Reaction

a D-amino acid
+
H2O
 +
O2
=
a 2-oxo carboxylate
 +
NH3
 +
H2O2

Synonyms

chDAO, D-AAO, D-amino acid oxidase, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO,  LH99

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.3 D-amino-acid oxidase

Inhibitors

Inhibitors on EC 1.4.3.3 - D-amino-acid oxidase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
-
MK-801, a drastic decline in the expression of DAO mRNA is observed in most brain areas 1 h after the MK-801 administration (1.6 mg/kg)
(5R)-4-hydroxy-3,5-dimethyl-5-[(1E)-2-methyl-1,3-butadienyl]-2(5H)-thiophenone
-
i.e. thiolactomycin, competitive inhibition, competes with both the substrate and the coenzyme FAD
([4-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]-1H-pyrrole-2-carbonyl]amino)acetic acid
100% inhibition at 0.02 mM
-
([4-[(4,5-dibromo-1H-pyrrole-2-carbonyl)amino]-1H-pyrrole-2-carbonyl]amino)acetic acid
100% inhibition at 0.02 mM
-
([4-[(4,5-dichloro-1H-pyrrole-2-carbonyl)amino]-1H-pyrrole-2-carbonyl]amino)acetic acid
100% inhibition at 0.02 mM
-
([4-[(4-bromo-1H-pyrrole-2-carbonyl)amino]-1H-pyrrole-2-carbonyl]amino)acetic acid
100% inhibition at 0.02 mM
-
1,3-Butadien 1-carboxylic acid
-
D-phenylglycine oxidation
1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylic acid
-
1H-indole-2-carboxylic acid
-
1H-pyrrole-2-carboxylic acid
-
2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid
2-(2,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
2-(3,3-dimethylbutyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
-
-
2-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
2-(hydroxymethyl)-5-((4-methoxybenzyl)oxy)-4H-pyran-4-one
-
2-aminobenzoic acid
-
about 35% inhibition at 0.2 mM
2-benzyl-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
-
-
2-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
2-Hydroxy acids
-
-
2-hydroxybenzoic acid
-
D-phenylglycine oxidation
2-hydroxybutyric acid
-
D-phenylglycine oxidation
2-ketobutyric acid
-
D-phenylglycine oxidation
2-nitrobenzoic acid
-
about 23% inhibition at 0.2 mM
2-oxo acids
-
-
2-oxobutyrate
-
D-alanine oxidation
2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
2-[(3,4-dichlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
-
2-[(4-chlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
-
2-[(4-fluorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
-
2-[(benzyloxy)methyl]-5-hydroxy-4H-pyran-4-one
-
2-[2-(1H-benzimidazol-1-yl)ethyl]-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
-
-
2-[[(1Z)-1-chloroprop-1-en-1-yl]sulfanyl]prop-2-enoic acid
-
-
2-[[(3,4-dichlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
2-[[(4-chlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
-
2-[[(4-fluorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
-
2-{[(3,4-dichlorophenyl)sulfanyl]methyl}-5-hydroxy-4H-pyran-4-one
-
-
3,3-dibromo-4-chloro-5-fluoro-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine
3-(2-phenylethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
3-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
3-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
3-(7-hydroxy-2-oxo-4-phenyl-2H-1-benzopyran-6-yl)propanoic acid
-
-
3-(benzylsulfanyl)-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-(hydroxymethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
3-benzyl-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-Bromobenzoic acid
-
D-phenylglycine oxidation
3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
3-chlorobenzoic acid
-
D-phenylglycine oxidation
3-cyano-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
-
3-hydroxy-1,5-naphthyridin-2(1H)-one hydrobromide
3-hydroxy-1,6-naphthyridin-2(1H)-one hydrobromide
3-hydroxy-1,7-naphthyridin-2(1H)-one hydrobromide
3-hydroxy-1,8-naphthyridin-2(1H)-one
-
-
3-hydroxy-1,8-naphthyridin-2(1H)-one hydrobromide
3-hydroxy-2H-1-benzopyran-2-one
3-hydroxy-4-methylquinolin-2(1H)-one
3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one
-
-
3-hydroxy-5-methylpyridin-2(1H)-one
-
-
3-hydroxy-5-methylquinolin-2(1H)-one
3-hydroxy-6-methylquinolin-2(1H)-one
3-hydroxy-7-methylquinolin-2(1H)-one
3-hydroxy-8-methylquinolin-2(1H)-one
3-Hydroxybenzoic acid
3-hydroxychromen-2-one
-
3-hydroxycoumarin
3-hydroxypyridin-2(1H)-one
-
-
3-hydroxyquinolin-2(1H)-one
3-hydroxyquinolin-2-(1H)-one
-
-
3-hydroxyquinolin-2-one
3-hydroxyquinoline-2-(1H)-one
-
very potent inhibitor
3-methyl-1H-pyrazole-5-carboxylic acid
-
-
3-methylbenzoic acid
-
D-phenylglycine oxidation
3-methylpyrazole-5-carboxylic acid
-
-
3-Nitrobenzoic acid
-
D-phenylglycine oxidation
3-pyridin-3-yl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
-
3-thiophencarboxylic acid
-
3-[(cyclohexylmethyl)sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[(1,2-benzoxazol-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[(2H-1,3-benzodioxol-5-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[(3,4-dichlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[(4-chlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[(4-tert-butylphenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[(6-fluoronaphthalen-2-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[([1,1'-biphenyl]-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
3-[[([1,1'-biphenyl]-4-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
-
-
4,5-dichlorofuran-2-carboxylic acid
-
4,5-dichlorothiophene-2-carboxylic acid
-
-
4,5-dimethylthiophene-2-carboxylic acid
-
-
4,6-difluoro-1-hydroxy-1,3-dihydro-2H-benzimidazol-2-one
-
-
4,6-difluoro-1-hydroxy-1H-benzo[d]imidazol-2(3H)-one
4-(difluoromethyl)thiophene-2-carboxylic acid
-
-
4-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
-
4-Aminobenzoic acid
-
about 30% inhibition at 0.2 mM
4-bromo-3-nitrobenzoate
there are two binding pockets of DAO to its inhibitor 4-bromo-3-nitrobenzoate, one is shared with substrate D-Ser and FAD, and the other is an cleft between the subunits of a DAO dimer
-
4-chloro-5-fluoro-1H-pyrrolo[2,3-b]pyridine-2,3-dione
4-fluoro-1,2-benzisoxazol-3-ol
-
-
4-hydroxy-6-(1-phenylethyl)pyridazin-3(2H)-one
-
-
4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one
-
-
4-hydroxy-6-(3-phenylpropyl)pyridazin-3(2H)-one
-
-
4-hydroxy-6-(phenoxymethyl)pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-(3-methoxyphenyl)ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-(4-methoxyphenyl)ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2H-1-benzopyran-6-yl)ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-[2-(trifluoromethyl)phenyl]ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-[3-(trifluoromethyl)phenyl]ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-[4-(trifluoromethyl)phenyl]ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-[7-hydroxy-4-(3-methoxyphenyl)-2-oxo-2H-1-benzopyran-6-yl]ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-[7-hydroxy-4-(3-methylphenyl)-2-oxo-2H-1-benzopyran-6-yl]ethyl]pyridazin-3(2H)-one
-
-
4-hydroxy-6-[2-[7-hydroxy-4-(4-methylphenyl)-2-oxo-2H-1-benzopyran-6-yl]ethyl]pyridazin-3(2H)-one
-
-
4-hydroxybenzoic acid
4-methylthiophene-2-carboxylic acid
-
-
4-nitrobenzoic acid
-
about 18% inhibition at 0.2 mM
4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-2-carboxylic acid
4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-3-carboxylic acid
-
4H-furo[3,2-b]pyrrole-5-carboxylic acid
4H-pyrrolo[2,3-d][1,3]oxazole-5-carboxylic acid
-
4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid
-
4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
-
4H-thieno [3,2-b]pyrrole-5-carboxylic acid
4H-thieno[3,2-b] pyrrole-5-carboxylic acid
4H-thieno[3,2-b]-pyrrole-5-carboxylic acid
-
-
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
5,5'-dithiobis-nitrobenzoate
-
-
5,6-dichloro-1,2-benzoxazol-3-ol
-
5,6-dihydro-4H-cyclopenta[b]thiophene-2-carboxylic acid
-
5-(difluoromethyl)thiophene-2-carboxylic acid
-
-
5-(trifluoromethyl)thiophene-2-carboxylic acid
-
-
5-bromo-1,2-benzisoxazol-3-ol
-
-
5-bromothiophene-2-carboxylic acid
-
-
5-chloro-3-hydroxypyridin-2(1H)-one
-
-
5-chloro-3-hydroxyquinolin-2(1H)-one
5-chloro-6-fluoro-3-hydroxy-1,8-naphthyridin-2(1H)-one hydrobromide
5-chloro-6-fluoro-3-hydroxyquinolin-2(1H)-one
5-chloro-benzo[d]isoxazol-3-ol
5-chlorothiophene-2-carboxylic acid
-
-
5-ethyl-3-hydroxyquinolin-2(1H)-one
5-fluoro-3-hydroxyquinolin-2(1H)-one
5-fluorothiophene-2-carboxylic acid
-
-
5-hydroxy-2-(2-phenylethyl)-4H-pyran-4-one
-
5-hydroxy-2-(methoxymethyl)-4H-pyran-4-one
-
5-hydroxy-2-(phenoxymethyl)-4H-pyran-4-one
-
5-hydroxy-2-[(naphthalen-1-yloxy)methyl]-4H-pyran-4-one
-
5-hydroxy-2-[(naphthalen-2-yloxy)methyl]-4H-pyran-4-one
-
5-hydroxy-2-[(phenylsulfanyl)methyl]-4H-pyran-4-one
-
5-hydroxy-2-[(pyridin-3-yloxy)methyl]-4H-pyran-4-one
-
5-hydroxy-2-[(pyrimidin-2-ylsulfanyl)methyl]-4H-pyran-4-one
-
5-hydroxy-3-(2-phenylethyl)-1,2,4-triazin-6(1H)-one
-
-
5-hydroxy-3-(3-phenylpropyl)-1,2,4-triazin-6(1H)-one
-
-
5-hydroxy-3-[(2-phenylethyl)sulfanyl]-1,2,4-triazin-6(1H)-one
-
-
5-hydroxy-3-[[(4-iodophenyl)methyl]sulfanyl]-1,2,4-triazin-6(1H)-one
-
-
5-hydroxy-4-methyl-3-[(naphthalen-1-yl)methyl]pyridine-2,6(1H,3H)-dione
-
-
5-iodo-1,2-benzisoxazol-3-ol
-
-
5-methyl-1H-pyrazole-3-carboxylic acid
-
-
5-Methylpyrazole-3-carboxylate
-
-
5-methylpyrazole-3-carboxylic acid
5-Methylthiophene-2-carboxylate
-
-
5-methylthiophene-2-carboxylic acid
-
-
5-nitro-1,2-benzisoxazol-3-ol
-
-
6-(2-cyclohexylethyl)-4-hydroxypyridazin-3(2H)-one
-
-
6-(3,3-dimethylbutyl)-4-hydroxypyridazin-3(2H)-one
-
-
6-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
-
6-chloro-1,2-benzisoxazol-3-ol
-
6-chloro-1,2-benzoxazol-3-ol
-
-
6-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
6-chloro-3-hydroxyquinolin-2(1H)-one
6-chlorobenzo(d)isoxazol-3-ol
-
-
6-chlorobenzo[d]isoxazol-3-ol
6-chlorobenzo[d]isoxazole-3-ol
-
-
6-cyclohexyl-4-hydroxypyridazin-3(2H)-one
-
-
6-ethoxy-1,2-benzisoxazol-3-ol
-
-
6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione .
-
-
6-fluoro-1,2-benzisoxazol-3-ol
-
-
6-fluoro-3-hydroxyquinolin-2(1H)-one
6-hydroxy-2-(2-(naphthalen-1-yl)ethyl)-1,2,4-triazine-3,5-(2H,4H)-dione
-
-
6-hydroxy-2-(2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-(3-methylbutyl)-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-(3-phenylpropyl)-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-phenyl-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-[(naphthalen-1-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-[(naphthalen-2-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-[2-(1H-pyrazol-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-hydroxy-2-[2-(pyridin-2-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
-
-
6-methoxy-1,2-benzisoxazol-3-ol
-
-
6-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
6-methyl-1,2-benzisoxazol-3-ol
-
-
6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
6-nitro-1,2-benzisoxazol-3-ol
-
-
6-phenethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
6-[(E)-2-(4-chlorophenyl)vinyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-(2-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-(3,5-difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-(3,5-dimethoxyphenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-(3-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-(4-chlorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-(4-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-[4-(3-chlorophenyl)-7-hydroxy-2-oxo-2H-1-benzopyran-6-yl]ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6-[2-[4-(4-chlorophenyl)-7-hydroxy-2-oxo-2H-1-benzopyran-6-yl]ethyl]-4-hydroxypyridazin-3(2H)-one
-
-
6H-thieno[2,3-b]pyrrole-5-carboxylic acid
-
7,8-dibromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7,8-dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-(5-oxoadipoamido)cephalosporanic acid
7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-bromo-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-chloro-3-hydroxyquinolin-2(1H)-one
7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-ethyl-3-hydroxyquinolin-2(1H)-one
7-fluoro-1,2-benzisoxazol-3-ol
-
-
7-fluoro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-fluoro-3-hydroxyquinolin-2(1H)-one
7-fluoro-6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
-
-
7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-hydroxypyrido[2,3-b]pyrazin-6(5H)-one
7-methyl-1,2-benzisoxazol-3-ol
-
-
7-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-chloro-3-hydroxyquinolin-2(1H)-one
8-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-ethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-ethyl-3-hydroxyquinolin-2(1H)-one
8-fluoro-3-hydroxyquinolin-2(1H)-one
8-isopropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-phenoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-phenylethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-phenylpropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
8-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
acetaldehyde
-
-
Acetylsalicylate
-
-
adenosine 5'-monophosphate
-
-
ADP
-
-
ADPribose
-
-
aniline
anthranilate
Benzamide
-
about 32% inhibition at 0.2 mM
benzoate
benzoic acid
benzo[d]isoxazol-3-ol
-
-
beta-naphthoflavone
Ca2+
-
83.1% residual activity at 10 mM
ceftriaxone
-
-
chloramphenicol
-
-
chlorpromazine
chlortetracycline
-
-
creatinine
75 mM, 86% inhibition
crotonate
crotonic acid
-
D-phenylglycine oxidation
cysteine
-
-
D-2-Hydroxy-3-methylvalerate
-
D-alanine oxidation
D-alanine
-
D-lactate
-
slight, D-alanine oxidation
D-malate
10 mM, 13.5% inhibition
D-proline
-
D-serine
dCMP
-
-
DELTA1-Piperidine 2-carboxylate
-
D-lysine oxidation
dephospho-CoA
-
-
DL-2-hydroxybutyrate
-
D-alanine oxidation
DL-2-Hydroxyoctanoate
-
D-alanine oxidation
Ethacrynic acid
-
-
Flufenamic acid
-
-
formaldehyde
-
-
Furosemide
-
-
glutaryl-7-aminocephalosporanic acid
Glycyl-DL-norvaline
-
slight, D-alanine oxidation
glycyl-DL-phenylalanine
-
slight, D-alanine oxidation
Glycyl-DL-tryptophan
-
slight, D-alanine oxidation
Glycyl-DL-valine
-
slight, D-alanine oxidation
HgCl2
0.1 mM, 71% inhibition
Histidyl-histidine
-
slight, D-alanine oxidation
imidazo[1,2-a]pyridine-6-carboxylic acid
-
indomethacin
-
-
iodoacetamide
iodoacetate
-
81.6% residual activity at 1 mM
KCl
-
about 30% residual activity at 250 mM KCl
kojic acid
L-histidine
-
D-histidine oxidation
L-leucine
-
D-alanine oxidation
L-methionine
L-norvaline
-
D-alanine oxidation
malate
-
78.6% residual activity at 10 mM
malonate
-
-
Mefenamic acid
-
-
Mersalyl
-
-
methyl 2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate
Mg2+
-
84.9% residual activity at 10 mM
NaCl
-
direct inhibition by NaCl is due to FAD dissociation
NADH
-
-
NADPH
-
-
nicotinate
-
-
nicotinic acid
-
D-phenylglycine oxidation
p-Aminosalicylic acid
-
-
p-chloromercuribenzoate
p-hydroxymercuribenzoate
-
significant inhibition (6.2% residual activity at 1 mM)
PCMB
75 mM, 93% inhibition
Penicillamine
-
-
penicillin
-
-
Phenylbutazone
-
-
Phenylmercuriacetate
-
-
phenylmethylsulfonyl fluoride
31.8% residual activity at 10 mM
Picolinic acid
-
D-phenylglycine oxidation
pLG72
-
poly(methylene-co-guanidine)
-
in the presence of poly(methylene-co-guanidine) (1.8%, w/v) the enzyme activity decreases irreversibly with a half-life time of about 1.75 min at 25°C
-
pyrrole-2-carboxylate
-
-
Pyrrolidine
-
slight, D-alanine oxidation
pyruvate
-
slight, D-alanine oxidation
quinoxaline-2,3-dione
riboflavin 5'-monophosphate
-
-
risperidone
salicylate
-
-
Silver nitrate
0.1 mM, 66% inhibition
Sodium benzoate
Straight-chain fatty acids
-
-
streptomycin
-
-
succinate
-
90.7% residual activity at 1 mM
succinate semialdehyde
-
-
Tartrate
-
79.5% residual activity at 10 mM
thiophene-2-carboxylic acid
-
trans-2-Pentenoic acid
-
D-phenylglycine oxidation
trifluoro-D-alanine
-
pseudo-substrate
tropolone
-
-
UMP
-
-
[[4-[(4,5-dibromo-1H-pyrrole-2-carbonyl)amino]-1H-pyrrole-2-carbonyl](methyl)amino]acetic acid
100% inhibition at 0.02 mM
-
additional information
-