1.4.3.3: D-amino-acid oxidase

This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.3

Reaction

a D-amino acid
+
H2O
+
O2
=
a 2-oxo carboxylate
+
NH3
+
H2O2

Synonyms

chDAO, D-AAO, D-amino acid oxidase, D-amino acid oxidases, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO,  LH99

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.3 D-amino-acid oxidase

IC50 Value

IC50 Value on EC 1.4.3.3 - D-amino-acid oxidase

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0057
1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.005
1,4-dihydropyrrolo[3,2-c]pyrazole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.000745
1H-indole-2-carboxylic acid
Homo sapiens
-
-
0.005
1H-pyrrole-2-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.005
2,3-dimethyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
1
2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylic acid
Sus scrofa
-
at pH 8.2 and 37°C
0.005
2-(2,4-dichlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.04
2-(3,3-dimethylbutyl)-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.005
2-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.005
2-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.0051
2-benzyl-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.005
2-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.005
2-chloro-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.005
2-phenyl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.0005
2-[(3,4-dichlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0007
2-[(4-chlorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
2-[(4-fluorophenoxy)methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.02
2-[(benzyloxy)methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00044
2-[2-(1H-benzimidazol-1-yl)ethyl]-6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.0001
2-[[(3,4-dichlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0002
2-[[(4-chlorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
2-[[(4-fluorophenyl)sulfanyl]methyl]-5-hydroxy-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.005
3-(3-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.005
3-(4-chlorophenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.0001
3-(benzylsulfanyl)-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.005
3-(hydroxymethyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.00007
3-benzyl-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.001426
3-chloro-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
-
0.001153
3-cyano-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
-
0.000128
3-hydroxy-1,5-naphthyridin-2(1H)-one hydrobromide
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.000032 - 0.003081
3-hydroxy-1,6-naphthyridin-2(1H)-one hydrobromide
0.000784
3-hydroxy-1,7-naphthyridin-2(1H)-one hydrobromide
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.000008 - 0.000424
3-hydroxy-1,8-naphthyridin-2(1H)-one hydrobromide
0.0173
3-hydroxy-4-methylquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.0000039
3-hydroxy-5-(2-phenylethyl)pyridin-2(1H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.00014
3-hydroxy-5-methylpyridin-2(1H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000016 - 0.00847
3-hydroxy-5-methylquinolin-2(1H)-one
0.00275
3-hydroxy-6-methylquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.000197
3-hydroxy-7-methylquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.000038
3-hydroxy-8-methylquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.0015
3-hydroxypyridin-2(1H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000004 - 0.000215
3-hydroxyquinolin-2(1H)-one
0.000004
3-hydroxyquinolin-2-(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000043 - 0.0001
3-hydroxyquinolin-2-one
0.000004
3-hydroxyquinoline-2-(1H)-one
Homo sapiens
-
at pH 7.0 and 25°C
0.005
3-pyridin-3-yl-4H-furo[3,2-b]pyrrole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.0006
3-[(cyclohexylmethyl)sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0002
3-[[(1,2-benzoxazol-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
3-[[(2H-1,3-benzodioxol-5-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
3-[[(3,4-dichlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
3-[[(4-chlorophenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0003
3-[[(4-tert-butylphenyl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00003
3-[[(6-fluoronaphthalen-2-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0007
3-[[([1,1'-biphenyl]-3-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00009
3-[[([1,1'-biphenyl]-4-yl)methyl]sulfanyl]-5-hydroxy-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.000343
4,5-dichlorofuran-2-carboxylic acid
Homo sapiens
-
-
0.1
4-(trifluoromethyl)-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
IC50 above 0.1 mM
0.00782
4-fluoro-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.0000049
4-hydroxy-6-(1-phenylethyl)pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000038
4-hydroxy-6-(2-phenylethyl)pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000013
4-hydroxy-6-(3-phenylpropyl)pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000022
4-hydroxy-6-(phenoxymethyl)pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000021
4-hydroxy-6-[2-(3-methoxyphenyl)ethyl]pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000029
4-hydroxy-6-[2-(4-methoxyphenyl)ethyl]pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000084
4-hydroxy-6-[2-[2-(trifluoromethyl)phenyl]ethyl]pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000024
4-hydroxy-6-[2-[3-(trifluoromethyl)phenyl]ethyl]pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000012
4-hydroxy-6-[2-[4-(trifluoromethyl)phenyl]ethyl]pyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000238
4-[2-(4-chlorophenyl)ethyl]-1H-pyrrole-3-carboxylic acid
Homo sapiens
-
-
0.0000014 - 0.000141
4H-furo[3,2-b]pyrrole-5-carboxylic acid
0.005
4H-pyrrolo[2,3-d][1,3]oxazole-5-carboxylic acid
Homo sapiens
-
IC50 above 0.005 mM
0.000516
4H-pyrrolo[2,3-d][1,3]thiazole-5-carboxylic acid
Homo sapiens
-
-
0.004204
4H-pyrrolo[3,2-d][1,3]thiazole-5-carboxylic acid
Homo sapiens
-
-
0.000114 - 0.000145
4H-thieno [3,2-b]pyrrole-5-carboxylic acid
0.000145
4H-thieno[3,2-b] pyrrole-5-carboxylic acid
0.000145 - 0.000245
4H-thieno[3,2-b]pyrrole-5-carboxylic acid
0.000599
5-bromo-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.000047
5-chloro-3-hydroxypyridin-2(1H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000004 - 0.00004
5-chloro-3-hydroxyquinolin-2(1H)-one
0.000003 - 0.000004
5-chloro-6-fluoro-3-hydroxy-1,8-naphthyridin-2(1H)-one hydrobromide
0.000005 - 0.00005
5-chloro-6-fluoro-3-hydroxyquinolin-2(1H)-one
0.000008 - 0.003665
5-ethyl-3-hydroxyquinolin-2(1H)-one
0.000008 - 0.000196
5-fluoro-3-hydroxyquinolin-2(1H)-one
0.0005
5-hydroxy-2-(2-phenylethyl)-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.05
5-hydroxy-2-(methoxymethyl)-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
5-hydroxy-2-(phenoxymethyl)-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0009
5-hydroxy-2-[(naphthalen-1-yloxy)methyl]-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0008
5-hydroxy-2-[(naphthalen-2-yloxy)methyl]-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.0002
5-hydroxy-2-[(phenylsulfanyl)methyl]-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.003
5-hydroxy-2-[(pyridin-3-yloxy)methyl]-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.004
5-hydroxy-2-[(pyrimidin-2-ylsulfanyl)methyl]-4H-pyran-4-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00006
5-hydroxy-3-(2-phenylethyl)-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.004
5-hydroxy-3-(3-phenylpropyl)-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.04
5-hydroxy-3-[(2-phenylethyl)sulfanyl]-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00005
5-hydroxy-3-[[(4-iodophenyl)methyl]sulfanyl]-1,2,4-triazin-6(1H)-one
Homo sapiens
-
pH and temperature not specified in the publication
0.00151
5-iodo-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.000901 - 0.00091
5-methylpyrazole-3-carboxylic acid
0.00295
5-nitro-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.0000047
6-(2-cyclohexylethyl)-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.00067
6-(3,3-dimethylbutyl)-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.3
6-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.005
6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.000507
6-chloro-1,2-benzisoxazol-3-ol
Homo sapiens
-
-
0.0203
6-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.000155
6-chloro-3-hydroxyquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.00009 - 0.00021
6-chlorobenzo[d]isoxazol-3-ol
0.0003
6-cyclohexyl-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.1
6-ethoxy-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
IC50 above 0.1 mM
0.1
6-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.000444
6-fluoro-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.000009 - 0.000308
6-fluoro-3-hydroxyquinolin-2(1H)-one
0.0001
6-hydroxy-2-(2-(naphthalen-1-yl)ethyl)-1,2,4-triazine-3,5-(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00007
6-hydroxy-2-(2-phenylethyl)-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00026
6-hydroxy-2-(3-methylbutyl)-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.0017
6-hydroxy-2-(3-phenylpropyl)-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.0028
6-hydroxy-2-methyl-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.1
6-hydroxy-2-phenyl-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00005
6-hydroxy-2-[(naphthalen-1-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00022
6-hydroxy-2-[(naphthalen-2-yl)methyl]-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00033
6-hydroxy-2-[2-(1H-pyrazol-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00031
6-hydroxy-2-[2-(1H-pyrrolo[2,3-b]pyridin-1-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00076
6-hydroxy-2-[2-(pyridin-2-yl)ethyl]-1,2,4-triazine-3,5(2H,4H)-dione
Homo sapiens
-
at pH 8.5 and 25°C
0.00257
6-methoxy-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.1
6-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.000269
6-methyl-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.0177
6-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.000722
6-nitro-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.3
6-phenethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00012
6-[(E)-2-(4-chlorophenyl)vinyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000002
6-[2-(2-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000015
6-[2-(3,5-difluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000013
6-[2-(3,5-dimethoxyphenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000014
6-[2-(3-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000027
6-[2-(4-chlorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.0000031
6-[2-(4-fluorophenyl)ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000063
6-[2-[3,5-bis(trifluoromethyl)phenyl]ethyl]-4-hydroxypyridazin-3(2H)-one
Homo sapiens
-
in 50 mM potassium phosphate buffer (pH 7.5), at 22°C
0.000269
6H-thieno[2,3-b]pyrrole-5-carboxylic acid
Homo sapiens
-
-
0.00053
7,8-dibromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00065
7,8-dichloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0124
7-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00048
7-bromo-8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0004
7-bromo-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0067
7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0001
7-chloro-3-hydroxyquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.00026 - 0.00416
7-chloro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.0226
7-ethyl-3-hydroxyquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.023
7-fluoro-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
-
0.00046
7-fluoro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00001 - 0.001445
7-fluoro-3-hydroxyquinolin-2(1H)-one
0.1
7-fluoro-6-(trifluoromethyl)-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
IC50 above 0.1 mM
0.00015 - 0.00034
7-fluoro-8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.05
7-hydroxypyrido[2,3-b]pyrazin-6(5H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.1
7-methyl-1,2-benzisoxazol-3-ol
Rattus norvegicus
-
IC50 above 0.1 mM
0.0367
7-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0229
7-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.3
8-(benzyloxy)-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00022 - 0.00224
8-bromo-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00024 - 0.00799
8-bromo-7-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.00014 - 0.00021
8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
0.000033 - 0.00872
8-chloro-3-hydroxyquinolin-2(1H)-one
0.1
8-ethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0024
8-ethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0144
8-ethyl-3-hydroxyquinolin-2(1H)-one
Homo sapiens
-
pH 8.5, recombinant enzyme, with substrate D-serine
0.000003 - 0.00018
8-fluoro-3-hydroxyquinolin-2(1H)-one
0.1
8-isopropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.0857
8-methoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00063
8-methyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
1
8-phenoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.3
8-phenylethoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.3
8-phenylpropoxy-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.00052
8-trifluoromethyl-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
0.016
Benzoate
Homo sapiens
-
pH and temperature not specified in the publication
0.00188
benzo[d]isoxazol-3-ol
Rattus norvegicus
-
-
0.002
kojic acid
Homo sapiens
-
pH and temperature not specified in the publication
1
methyl 2,3-dioxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine-7-carboxylate
Sus scrofa
-
at pH 8.2 and 37°C
300
NaCl
Trigonopsis variabilis
-
in 100 mM potassium phosphate buffer pH 8.0, at 30°C
0.0336
quinoxaline-2,3-dione
Sus scrofa
-
at pH 8.2 and 37°C
additional information
additional information
Homo sapiens
-
IC50 with substrate D-aspartate, overview
-