1.4.3.3: D-amino-acid oxidase

This is an abbreviated version!
For detailed information about D-amino-acid oxidase, go to the full flat file.

Word Map on EC 1.4.3.3

Reaction

a D-amino acid
+
H2O
+
O2
=
a 2-oxo carboxylate
+
NH3
+
H2O2

Synonyms

chDAO, D-AAO, D-amino acid oxidase, D-amino acid oxidases, D-amino-acid-oxidase, D-aminoacid oxidase, DAAO, DAMOX, DAO, DAO1, DaoE, hDAAO, ophio-amino-acid oxidase, oxidase, D-amino acid, PEG-DAO, pkDAAO, RgDAAO, TvDAAO, TvDAO, LH99

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.3 D-amino-acid oxidase

Activating Compound

Activating Compound on EC 1.4.3.3 - D-amino-acid oxidase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine
-
MK-801, a dose-dependent elevation in the expression of DAO mRNA is observed in most brain areas 4 h after the administration (1.6 mg/kg)
2,3-Butanedione
115% activity at 10 mM
D-amino acid oxidase activator
-
i.e. DAOA or G72, the gene encoding the activator is located on chromosome 13q32-34
-
D-malate
107% activity at 10 mM
DAO activator
-
DAOA, formerly G72
-
G72 protein
-
-
-
iodoacetate
112% activity at 10 mM
morphine
-
the chronic treatment with morphine produces a slight but significant enhancement in the levels of DAO mRNA in the forebrain regions, the levels increases by 24%-102% in the striatum (87% increase), hippocampus (102%), and cortex (24%)
pLG72
-
additional information
-