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1.4.3.21: primary-amine oxidase

This is an abbreviated version!
For detailed information about primary-amine oxidase, go to the full flat file.

Word Map on EC 1.4.3.21

Reaction

RCH2NH2
+
H2O
 +
O2
=
RCHO
 +
NH3
 +
H2O2

Synonyms

AGAO, AMAO2, AMAO3, amine oxidase 1, amine oxidase, copper containing, AO1, AO2, AOC2, AOC3, BAO, benzylamine oxidase, bovine plasma amine oxidase, bovine serum amine oxidase, BPAO, BSAO, CAO, Copper amine oxidase, copper amine oxidase 1, copper amine oxidase 8, copper-containing amine oxidase, copper-containing AO, copper-containing monoamine oxidase, copper-dependent amine oxidase, copper/quinone containing amine oxidase, Cu/TPQ amine oxidase, CuAO, CuAO1, CuAO2, CuAO3, CuAO8, EC 1.4.3.6, ECAO, ELAO, GPAO, grass pea amine oxidase, Hansenula polymorpha amine oxidase, HPAO, hPAO-1, HPAO-2, lentil seedling amine oxidase, LSAO, MAO-N, More, OVAO, PAO, pea seedling amine oxidase, plasma amine oxidase, PrAO, primary amine oxidase, primary-amine:oxygen oxidoreductase, PSAO, quinone- and copper-containing amine oxidase, quinone-containing copper amine oxidase, quinone-dependent amine oxidase, quinoprotein copper-containing amine oxidase, RAO, sainfoin amine oxidase, semicarbazide-sensitive amine oxidase, semicarbazide-sensitive amine oxidase/vascular adhesion protein-1, SSAO, SSAO/VAP-1, TPQ-containing CuAO, tynA, tyramine oxidase, copper-requiring, VAP-1, vascular adhesion protein 1, vascular adhesion protein-1

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.21 primary-amine oxidase

Cloned

Cloned on EC 1.4.3.21 - primary-amine oxidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
AOC2, cDNA library screening, DNA and amino acid sequence determination and analysis, transient expression of wild-type enzyme in HEK293, HEK293-EBNA or CHO cells
AOC3, cDNA library screening, transient expression of wild-type and mutant enzymes in HEK293, HEK293-EBNA or CHO cells
expressed in COS-1 cells
expressed in Drosophila melanogaster Schneider-2 cells and in 3T3-L1 mouse adipocytes
expressed in Escherichia coli BL21(DE3) cells
expressed in Escherichia coli BL21(DE3)pLysS cells
expressed in Escherichia coli CD03 cells
-
expressed in Escherichia coli DH5alpha cells
expressed in Escherichia coli JM109 cells
expressed in Nicotiana benthamiana
expressed in Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae INVSC-1 cells
expression in CHO cells
expression of wild-type and mutant enzymes, expression of selenomethionine-labeled truncated mutant MAO-N-D5 in Escherichia coli strain B834(DE3)
-
expression Saccharomyces cerevisiae
-
genes cao1+ and cao2+, cDNA library screening, DNA and amino acid determination and analysis, both genes are expressed in wild-type cells, but only the expression of cao1+,not of cao2+, results in production of an active enzyme. Expression of cao1+ and cao2+ is copper-independent and is not regulated by Cuf1. Recombinant expression of GFP-tagged Cao1 in the cytosol, expression of wild-type and mutant enzymes in Saccharomyces cerevisiae
-
mice overexpressing human semicarbazide-sensitive amine oxidase in smooth muscle cells. No differences in elastin quantity or lung capacity could be observed between transgenic or nontransgenic littermates. Pulse pressure is higher in transgenic mice, and aorta shows elastin fibers parallel with the aorta wall (i. e., straight fibers instead of folded compared with control mice). No difference in the response to adrenaline or sodium chloride is observed between the transgenic and control mice. The control mice have a clear decrease in blood pressure with a longer duration as a response to injection of a nitric oxide donor, sodium nitroprusside, compared with transgenic mice where only a minor response is observed. The SSAO activity in serum of control mice is elevated in response to injection of the NO donor, but not in response to a ganglion blocker
-
overexpression in CHO cells
-
overexpression of His-tagged wild-type and mutants enzymes in Escherichia coli strain Rosetta2(DE3)
-