1.4.3.20: L-lysine 6-oxidase

This is an abbreviated version!
For detailed information about L-lysine 6-oxidase, go to the full flat file.

Word Map on EC 1.4.3.20

Reaction

L-lysine
+
O2
+
H2O
=
(S)-2-amino-6-oxohexanoate
+
H2O2
+
NH3

Synonyms

ALPP, epsilon-lysine oxidase, L-lysine epsilon-oxidase, L-lysine-epsilon oxidase, L-lysine-epsilon-oxidase, Lod, LodA, lysine-epsilon oxidase, lysine-epsilon-oxidase, marinocine, marinocine antimicrobial protein

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.20 L-lysine 6-oxidase

Engineering

Engineering on EC 1.4.3.20 - L-lysine 6-oxidase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
C448A
the mutation causes large increases in the Km values for L-lysine
C448D
the mutation causes large increases in the Km values for L-lysine
K530A
the variant exhibits diminished levels of cysteine tryptophylquinone but significantly increased kcat value. The mutation causes large increases in the Km values for L-lysine
K530R
the variant exhibits diminished levels of cysteine tryptophylquinone but significantly increased kcat value. The mutation causes large increases in the Km values for L-lysine
Y211A
the variant the highest level of cysteine tryptophylquinone but exhibits no activity
Y211E
the variant the highest level of cysteine tryptophylquinone but exhibits no activity
Y211F
the mutant has reduced levels of cysteine tryptophylquinone but near normal levels of kcat. The mutation causes large increases in the Km values for L-lysine
C448A
-
the mutation causes large increases in the Km values for L-lysine
0
K530A
-
the variant exhibits diminished levels of cysteine tryptophylquinone but significantly increased kcat value. The mutation causes large increases in the Km values for L-lysine
0
K530R
-
the variant exhibits diminished levels of cysteine tryptophylquinone but significantly increased kcat value. The mutation causes large increases in the Km values for L-lysine
0
Y211A
-
the variant the highest level of cysteine tryptophylquinone but exhibits no activity
0
Y211F
-
the mutant has reduced levels of cysteine tryptophylquinone but near normal levels of kcat. The mutation causes large increases in the Km values for L-lysine
0