1.4.3.13: protein-lysine 6-oxidase
This is an abbreviated version!
For detailed information about protein-lysine 6-oxidase, go to the full flat file.
Word Map on EC 1.4.3.13
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1.4.3.13
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collagen
-
fibrosis
-
metastasis
-
fiber
-
copper
-
crosslinking
-
amine
-
elastic
-
glaucoma
-
aortic
-
stiff
-
beta-aminopropionitrile
-
tropoelastin
-
copper-dependent
-
fibril
-
metalloproteinases
-
procollagens
-
biomechanical
-
propeptide
-
exfoliation
-
fibrillar
-
tensile
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myofibroblasts
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aneurysm
-
pseudoexfoliation
-
cutis
-
copper-binding
-
fibrillin-1
-
open-angle
-
menkes
-
copper-deficient
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prolapse
-
fibrillogenesis
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cross-linkage
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desmosine
-
copper-containing
-
medicine
-
benzylamine
-
diagnostics
-
pentosidine
-
synthesis
-
microfibrillar
-
microfibrils
-
elastosis
-
ehlers-danlos
-
elastolytic
-
col3a1
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semicarbazide-sensitive
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cuproenzymes
-
c-proteinase
-
fibulins
-
hydroxylysine
-
pyridinoline
- 1.4.3.13
- collagen
- fibrosis
- metastasis
- fiber
- copper
-
crosslinking
- amine
-
elastic
- glaucoma
- aortic
-
stiff
- beta-aminopropionitrile
- tropoelastin
-
copper-dependent
-
fibril
- metalloproteinases
- procollagens
-
biomechanical
- propeptide
-
exfoliation
-
fibrillar
-
tensile
- myofibroblasts
- aneurysm
-
pseudoexfoliation
- cutis
-
copper-binding
- fibrillin-1
-
open-angle
- menkes
-
copper-deficient
-
prolapse
-
fibrillogenesis
-
cross-linkage
- desmosine
-
copper-containing
- medicine
- benzylamine
- diagnostics
-
pentosidine
- synthesis
-
microfibrillar
-
microfibrils
-
elastosis
- ehlers-danlos
-
elastolytic
-
col3a1
-
semicarbazide-sensitive
-
cuproenzymes
-
c-proteinase
-
fibulins
- hydroxylysine
-
pyridinoline
Reaction
Synonyms
elastin synthetase, LO, LOR2, LOX, LOX-like 2, LOX-like 3, LOX-like protein, LOX-PP, LOXL, LOXL-2, LOXL1, LOXL1 protein, Loxl2, LOXL2a, Loxl3, LOXL3-sv1, LOXL3a, LOXL3b, LOXL4, LOXL5a, LOXL5b, lysyl oxidase, lysyl oxidase 1, lysyl oxidase 3, lysyl oxidase homolog 2, lysyl oxidase like 4, lysyl oxidase like-1, lysyl oxidase like-1 protein, lysyl oxidase propetide, lysyl oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 2a, lysyl oxidase-like 2b, lysyl oxidase-like 3a, lysyl oxidase-like 3b, lysyl oxidase-like 4, lysyl oxidase-like 5a, lysyl oxidase-like 5b, lysyl oxidase-like protein, lysyl oxidase-like1 protein, lysyl oxidases, More, oxidase-like protein 1, PPLO, protein-6-oxidase, protein-L-lysine:oxygen 6-oxidoreductase, protein-lysine 6-oxidase, RAS excision protein, rDmLOXL-1, WS9-14
ECTree
1.4.3.13 protein-lysine 6-oxidaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.4.3.13 - protein-lysine 6-oxidase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
collagen 2a1 + O2 + H2O
?
-
-
-
?
histone H2 + O2 + H2O
?
-
recombinant mature LOX and C-terminally deleted enzyme
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
tropoelastin + O2 + H2O
? + H2O2 + NH3
-
oxidation of L-lysine residues, substrate from mammalia
-
-
?
[elastin]-L-lysine + O2 + H2O
[elastin]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
-
-
?
collagen + H2O + O2
allysyl-collagen + NH3 + H2O2
-
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity
-
-
?
elastin + H2O + O2
allysyl-elastin + NH3 + H2O2
-
the enzyme initiates the enzymatic stage of collagen and elastin cross-linking. Lysyl oxidase activity is essential for the integrity maintenance of the dermis and for the homeostasis of the epidermis. The LOX protein plays a role in the skin carcinomas and invasion but not through its enzymatic activity
-
-
?
histone H1 + O2 + H2O
?
-
recombinant mature LOX and C-terminally deleted enzyme
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-hydroxylysyl-peptide + O2 + H2O
peptidyl-L-2-amino-5-hydroxy-6-oxohexanoyl-peptide + NH3 + H2O2
-
part of tropocollagen and tropoelastin
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
deamination of lysyl and hydroxylysyl residues is part of the pyridinoline biosynthetic pathway, pyridinoline is involved in formation of intracellular and extracellular collagen cross-links responsible for aging of connective tissue
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in a variety of basic globular proteins
i.e. peptidyl-L-alpha-aminoadipic-delta-semialdehyde
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
key enzyme in formation of lysine cross-links in side collagen and elastin molecules
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
substrates are proteins of the extracellular matrix
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in a variatey of basic globular proteins
i.e. peptidyl-L-alpha-aminoadipic-delta-semialdehyde
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in collagen and elastin fibrills
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
formation of cross-links in mature fibrillar collagen and elastin fibers in the extracellular space
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
initiation of covalent intermolecular cross-linking of collagen by the enzyme action on telopeptidyl lysine and hydroxylysine residues
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
lysyl oxidase plays a critical role in the formation of the extracellular matrix, and its activity is required for the normal maturation and cross-linking of collagen and elastin
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
enzyme plays a critical role in the formation and repair of extracellular matrix, formation of cross-links in fibrillar collagen and elastin, only in fibrillar aggregates
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
in a variatey of basic globular proteins
i.e. peptidyl-L-alpha-aminoadipic-delta-semialdehyde
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
-
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
part of tropocollagen and tropoelastin
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
part of elastin and collagen
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
part of elastin and collagen
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
-
-
?
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-L-allysyl-peptide + NH3 + H2O2
-
crosslinkage in fibrillar collagen and elastin
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
-
-
-
?
[collagen]-L-lysine + O2 + H2O
[collagen]-(S)-2-amino-6-oxohexanoate + NH3 + H2O2
the enzyme catalyzes the oxidative deamination of lysine residues of extracellular matrix proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for modeling of extracellular matrix
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments
-
-
?
additional information
?
-
-
enzyme contains a cytokine receptor domain, substrate specificity, preference for the L-lysine residues in the sequence N-acetyl-(Gly)4-Glu-Lys-(Gly)5-amide, enzyme is tightly associated to the substrates in connective tissue
-
-
?
additional information
?
-
-
the enzyme does not affect smooth muscle cell proliferation nor elastin precursor, tropoelastin, synthesis, nor total elastin synthesis in a per-cell-basis
-
-
?
additional information
?
-
-
critical role for lysyl oxidase in zebrafish notochord morphogenesis
-
-
?
additional information
?
-
LOX induced chromatin changes, mechanism via histone deamination
-
-
?
additional information
?
-
LOX induced chromatin changes, mechanism via histone deamination
-
-
?
additional information
?
-
lysyl oxidase gene family. Enzyme seems to be involved in binding and crosslinking to other cell-surface and extracellular-matrix proteins
-
-
?
additional information
?
-
-
lysyl oxidase gene family. Enzyme seems to be involved in binding and crosslinking to other cell-surface and extracellular-matrix proteins
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments, enzyme expression in downregulated in Menkes disease, a disorder of copper transport
-
-
?
additional information
?
-
-
LOX induced chromatin changes, mechanism via histone deamination
-
-
?
additional information
?
-
-
the enzyme forms are differently involved in tumor suppression, cellular senescence, and chemotaxis
-
-
?
additional information
?
-
-
enzyme contains a cytokine receptor domain, substrate specificity, preference for the L-lysine residues in the sequence N-acetyl-(Gly)4-Glu-Lys-(Gly)5-amide, enzyme is tightly associated to the substrates in connective tissue
-
-
?
additional information
?
-
-
lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain
-
-
?
additional information
?
-
-
lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain
-
-
?
additional information
?
-
-
potential role of lysyl oxidase/placental lactogen interactions in breast epithelial cell proliferation and migration
-
-
?
additional information
?
-
-
LOXL3 encodes two variants, LOXL3 and LOXL3-sv1, both of which function as amine oxidases with distinct tissue and substrate specificities
-
-
?
additional information
?
-
-
catalyzes the cross-linking of collagens or elastin in the extracellular compartment, thereby regulating the tensile strength of tissues
-
-
?
additional information
?
-
-
purifiedLOXreadily oxidizes peptidyl lysines in basic globular proteins with isoelectric points greater than pH 8, whereas no oxidation is detected in neutral or acidic proteins with isoelectric points less than pH 8
-
-
?
additional information
?
-
-
LOX is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin side chains and thereby contributes to extracellular matrix integrity
-
-
?
additional information
?
-
-
LOX is an extracellular matrix-remodeling enzyme involved in regulation of tumor metastasis
-
-
?
additional information
?
-
-
LOX secreted by hypoxic breast tumor cells accumulates at premetastatic sites, crosslinks collagen IV in the basement membrane, and is essential for CD11b+ myeloid cell recruitment. LOX inhibition prevents CD11b+ cell recruitment and metastatic growth. CD11b+ cells and LOX also colocalize in biopsies of human metastases, detailed overview
-
-
?
additional information
?
-
apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC12 cells
-
-
?
additional information
?
-
-
apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC12 cells
-
-
?
additional information
?
-
-
enzymatic activity is assayed using a peroxide-coupled assay and the nonpeptidyl substrate 1,5-diaminopentane producing the corresponding aldehyde
-
-
?
additional information
?
-
-
enzyme is responsible for the cross-linking of collagen and elastin, and is required for vascular and diaphragmatic development during embryogenesis
-
-
?
additional information
?
-
-
expression of isozymes LOXL1,3,4 during osteoblast differentiation is highly regulated due to their distinct roles in collagen matrix stabilization and subsequent mineralization
-
-
?
additional information
?
-
-
LOX is essential for collagen and elastin matrix stability and newborn animal survival
-
-
?
additional information
?
-
-
lysyl oxidase and 4 LOX-like proteins LOXL, LOXL2, LOXL3, and LOXL4 all contain a cytokine receptor-like domain
-
-
?
additional information
?
-
-
lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues
-
-
?
additional information
?
-
-
catalyzes the cross-linking of collagens or elastin in the extracellular compartment, thereby regulating the tensile strength of tissues
-
-
?
additional information
?
-
-
purified LOX readily oxidizes peptidyl lysines in basic globular proteins with isoelectric points greater than pH 8, whereas no oxidation is detected in neutral or acidic proteins with isoelectric points less than pH 8
-
-
?
additional information
?
-
-
lysyl oxidase, an amine oxidase, is critical for the initiation of collagen and elastin cross-linking, binds transforming growth factor-beta, and regulates its signaling via amine oxidase activity, mechanism, overview. LOX suppresses TGF-beta1-induced Smad3 phosphorylation likely through its amine oxidase activity
-
-
?
additional information
?
-
-
the enzyme forms desmosine crosslinking structures in elastic fibers contributing to the elasticity
-
-
?
additional information
?
-
-
enzyme modifies cellular activity and can function as a messenger shuttling information between the intra- and extracellular compartments
-
-
?
additional information
?
-
-
enzyme contains a cytokine receptor domain, substrate specificity, preference for the L-lysine residues in the sequence N-acetyl-(Gly)4-Glu-Lys-(Gly)5-amide, enzyme is tightly associated to the substrates in connective tissue
-
-
?
additional information
?
-
-
lysyl oxidase is a copper-dependent amine oxidase that catalyzes the crosslinking of collagens and elastin, and is thus critical for the stability of the extracellular matrix
-
-
?
additional information
?
-
apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC-12 cells
-
-
?
