1.4.3.13: protein-lysine 6-oxidase

This is an abbreviated version!
For detailed information about protein-lysine 6-oxidase, go to the full flat file.

Word Map on EC 1.4.3.13

Reaction

[protein]-L-lysine
+
O2
+
H2O
=
[protein]-(S)-2-amino-6-oxohexanoate
+
NH3
+
H2O2

Synonyms

elastin synthetase, LO, LOR2, LOX, LOX-like 2, LOX-like 3, LOX-like protein, LOX-PP, LOXL, LOXL-2, LOXL1, LOXL1 protein, Loxl2, LOXL2a, Loxl3, LOXL3-sv1, LOXL3a, LOXL3b, LOXL4, LOXL5a, LOXL5b, lysyl oxidase, lysyl oxidase 3, lysyl oxidase homolog 2, lysyl oxidase like 4, lysyl oxidase like-1, lysyl oxidase like-1 protein, lysyl oxidase propetide, lysyl oxidase-like, lysyl oxidase-like 1, lysyl oxidase-like 2, lysyl oxidase-like 2a, lysyl oxidase-like 2b, lysyl oxidase-like 3a, lysyl oxidase-like 3b, lysyl oxidase-like 4, lysyl oxidase-like 5a, lysyl oxidase-like 5b, lysyl oxidase-like protein, lysyl oxidase-like1 protein, lysyl oxidases, More, oxidase-like protein 1, PPLO, protein-6-oxidase, protein-L-lysine:oxygen 6-oxidoreductase, protein-lysine 6-oxidase, RAS excision protein, rDmLOXL-1, WS9-14

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.3 With oxygen as acceptor
                1.4.3.13 protein-lysine 6-oxidase

Source Tissue

Source Tissue on EC 1.4.3.13 - protein-lysine 6-oxidase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
LOX is highly expressed in early gestational amnion tissue (12-14 weeks)
Manually annotated by BRENDA team
-
highly expressed in vascular lesions
Manually annotated by BRENDA team
-
mineral-associated fraction
Manually annotated by BRENDA team
-
LOX and LOXL
Manually annotated by BRENDA team
-
LOX and LOXL
Manually annotated by BRENDA team
-
LOX on the surface of pyramidal cells in the grey matter, LOXL in the nuclei of cortex cells and in the cytosol of capillary endothelial cells
Manually annotated by BRENDA team
-
localization of LOX and LOXL in different tissue areas
Manually annotated by BRENDA team
-
mature form of LOXL1 and polymerized LOXL1protein forms
Manually annotated by BRENDA team
-
polymerized LOXL1protein forms
Manually annotated by BRENDA team
-
of lung: LOX and LOXL, renal tubules: only LOXL, intestinal: only LOXL
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
of the stomach, mainly LOXL, mucous-secreting cells
Manually annotated by BRENDA team
-
including dermal papillae, follicular sheaths, sebaceous glands
Manually annotated by BRENDA team
-
pyramidal cells: LOXL, not LOX
Manually annotated by BRENDA team
-
epithelial cells, LOXL
Manually annotated by BRENDA team
-
mature form of LOXL1 and polymerized LOXL1protein forms
Manually annotated by BRENDA team
-
LOX and LOXL, of skin epidermis and hair follicles
Manually annotated by BRENDA team
LOXL-1; LOXL-1, no expression of LOXL-2
Manually annotated by BRENDA team
-
determination of LOX activity and expression in donor ocular tissues
Manually annotated by BRENDA team
-
LOX gene expression is reduced in lung cancer cells
Manually annotated by BRENDA team
-
in MCF-10A normal breast epithelial cells stably expressing lysyl oxidase LOX has no effect on cell proliferation. Coexpression of lysyl oxidase and placental lactogen leads to a 121% increase in cell proliferation
Manually annotated by BRENDA team
-
polymerized LOXL1protein forms
Manually annotated by BRENDA team
-
LOX mRNA is upregulated in OSCC cells
Manually annotated by BRENDA team
-
LOX gene expression is reduced in pancreatic cancer cells
Manually annotated by BRENDA team
apparent lysyl oxidase isozymes contain a highly conserved LOX active site sequence in the nuclei of PC-12 cells
Manually annotated by BRENDA team
-
pepsin-secreting, in the basal part of the stomach, only LOX, no LOXL
Manually annotated by BRENDA team
-
LOXL2, LOX, LOXL
Manually annotated by BRENDA team
LOXL-1; LOXL-1, no expression of LOXL-2
Manually annotated by BRENDA team
-
determination of LOX activity and expression in donor ocular tissues
Manually annotated by BRENDA team
-
localization of LOX and LOXL in different tissue areas
Manually annotated by BRENDA team
-
LOXL2, LOX, LOXL
Manually annotated by BRENDA team
-
proliferating cell, LOXL expression, adult tissues
Manually annotated by BRENDA team
-
determination of LOX activity and expression in donor ocular tissues
Manually annotated by BRENDA team
additional information