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(1Z)-butanal thiosemicarbazone
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(2-chloropyridin-4-yl)methanamine
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1-(2-chloropyridin-4-yl)methanamine
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1-(2-fluoropyridin-4-yl)methanamine
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1-(2-methoxypyridin-4-yl)methanamine
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1-(2-phenoxypyridin-4-yl)methanamine
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1-(3,5-diethoxypyridin-4-yl)methanamine dihydrochloride
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1-(3-fluoropyridin-4-yl)methanamine
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1-(4-fluorophenyl)methanamine
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1-(4-methoxyphenyl)methanamine
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1-(4-nitrophenyl)methanamine
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1-(pyridin-4-yl)methanamine
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1-(quinolin-4-yl)methanamine
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1-([2,3'-bipyridin]-4-yl)methanamine
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1-[2-(1H-imidazol-1-yl)pyridin-4-yl]methanamine
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1-[2-(trifluoromethyl)pyridin-4-yl]methanamine
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1-[3-(benzyloxy)-5-ethoxypyridin-4-yl]methanamine dihydrochloride
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1-[3-(hydrazinylmethyl)phenyl]methanamine
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1-[4-(1,3-thiazol-2-yl)phenyl]methanamine
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1-[4-(hydrazinylmethyl)phenyl]methanamine
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1-[5-(trifluoromethyl)[2,3'-bipyridin]-4-yl]methanamine
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2-(pyridin-4-yl)ethan-1-amine
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2-Aminopropionitrile
i.e. BAPN, is an irreversible inhibitor of LOX, involved in regulating the metastatic colonization potential of the human breast cancer cell line MDAMB-231
2-mercaptoethanol
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weakly inhibitory
2-mercaptopyridine-N-oxide
2-phenylcyclopropan-1-amine
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2-phenylethan-1-amine
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3,3'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dipropan-1-ol dihydrochloride
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3,4-dihydroxybenzoate
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4,4'-[[4-(aminomethyl)pyridine-3,5-diyl]bis(oxy)]dibutan-1-ol dihydrochloride
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4-(aminomethyl)aniline
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4-(aminomethyl)benzonitrile
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4-deoxypyridoxine
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pyridoxal analogue, 50% inhibition at 3 mM
alpha2-Macroglobulin
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ascorbic acid
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inhibits the purified enzyme in vitro, and the formation of cross-linked collagen
basic fibroblast growth factor
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reduces enzyme expression in osteogenic cells
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cyclohexanone thiosemicarbazone
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cyclopentanone thiosemicarbazone
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diethyldithiocarbamate
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Disulfiram
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a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview
erythorbic acid
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stereoisomer of ascorbic acid
glutathione
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slight inhibition
Isonicotinic acid hydrazide
low-density lipoprotein
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methyl 3-(aminomethyl)benzoate
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methyl 4-(aminomethyl)benzoate
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N-[2-([2-[(1-oxidopyridin-2-yl)sulfanyl]ethyl]amino)ethyl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
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fully effective at 0.02 mM
tert-butyl [2-[(1-oxidopyridin-2-yl)sulfanyl]ethyl]carbamate
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fully effective at 0.002 mM
thiram
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a dithiocarbamate and Cu2+-chelator, inhibits the enzyme and causes teratogenic effects, malformations, distorted notochord development, and shortened anterior to posterior axis in zebrafish, overview
tumor necrosis factor-alpha
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VE-statin/egfl7 protein
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interacts with the catalytic domain of lysyl oxidase thereby preventing the crosslink of tropoelastin molecules into mature elastin polymers and regulating vascular elastogenesis
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Zn2+
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slightly inhibitory
2-mercaptopyridine-N-oxide
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fully effective at 200 nM
2-mercaptopyridine-N-oxide
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3-aminopropanenitrile
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3-aminopropanenitrile
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irreversible LOX inhibitor
3-aminopropanenitrile
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beta-aminopropionitrile
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80% inhibition at 0.5 mM
beta-aminopropionitrile
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beta-aminopropionitrile
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beta-aminopropionitrile
inhibition of LOXL-1
beta-aminopropionitrile
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lathyrogen, organic nitrile group, blocks active site irreversibly and binds covalently
beta-aminopropionitrile
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irreversible
beta-aminopropionitrile
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total inhibition at 1 mM
beta-aminopropionitrile
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beta-aminopropionitrile
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selective inhibition of mammalian LOX
beta-aminopropionitrile
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inhibition of active recombinant LOX, LOXL1, and LOXL2, specific
beta-aminopropionitrile
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irreversible, competitive inhibitor
beta-aminopropionitrile
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0.1-0.3 mM, specific inhibitor
beta-aminopropionitrile
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0.5 mM
beta-aminopropionitrile
a specific lysyl oxidase inhibitor, diminishes the metastatic colonization potential of circulating breast cancer cells, detailed overview
beta-aminopropionitrile
a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation
beta-aminopropionitrile
a specific LOX inhibitor
beta-aminopropionitrile
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LOX activity is inhibited by 0.5 mM and above concentrations
beta-aminopropionitrile
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beta-aminopropionitrile
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complete inhibition at 0.5 mM
beta-aminopropionitrile
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competitive inhibitor
beta-aminopropionitrile
0.4 mM, 20% inhibition
beta-aminopropionitrile
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selective inhibition of mammalian LOX
beta-aminopropionitrile
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beta-aminopropionitrile
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0.1 mM, irreversible inhibition
beta-aminopropionitrile
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irreversible, competitive inhibitor
beta-aminopropionitrile
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beta-aminopropionitrile
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beta-aminopropionitrile
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irreversible inhibitor
beta-aminopropionitrile
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beta-aminopropionitrile
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0.1 mM, irreversible inhibition
beta-aminopropionitrile
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reduces LOX activity and significantly increases MCP-1 secretion in vascular smooth uscle cells
beta-aminopropionitrile
a highly specific lysyl oxidase inhibitor that reportedly blocks LOX inhibition of Ras-induced oocyte maturation
beta-aminopropionitrile
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cycloheximide
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inhibits incorporation of lysine and Cu2+ into enzyme, blocks activating process
cycloheximide
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prevents stimulation by transforming growth factor-beta1
homocysteine
0.03 mM, up to 50% inhibition
homocysteine
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down-regulates LOX mRNA and transcriptional activity
homocysteine
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down-regulates LOX mRNA and transcriptional activity
homocysteine thiolactone
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homocysteine thiolactone
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homocysteine thiolactone
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Isonicotinic acid hydrazide
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lathyrogen, hydrazide group
Isonicotinic acid hydrazide
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reversible, 61.8% of full activity restored by pyridoxal or 30.1% by pyrroloquinoline-quinone
low-density lipoprotein
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decreases lysyl oxidase mRNA levels in endothelial cells
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low-density lipoprotein
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down-regulates LOX expression
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low-density lipoprotein
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low-density lipoprotein
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phenylhydrazine
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Semicarbazide
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lathyrogen, ureide group
Semicarbazide
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reversible, 21.2% of full activity restored by pyridoxal or 10% by pyrroloquinoline-quinone
TNFalpha
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TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity
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TNFalpha
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TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and decreases endothelial LOX enzymatic activity
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TNFalpha
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TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity
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TNFalpha
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TNFalpha decreases LOX mRNA levels in endothelial cells in a dose- and time-dependent manner (2fold at 1 ng/ml and maximum at 2.5 ng/ml) and endothelial LOX enzymatic activity
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tumor necrosis factor-alpha
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down-regulates LOX expression
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tumor necrosis factor-alpha
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inhibits LOX mRNA transcription and LOX activity
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tumor necrosis factor-alpha
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inhibits LOX mRNA transcription and LOX activity
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additional information
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no inhibition by dehydroascorbic acid
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additional information
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LOXL4 suppresses the expression of laminins and alpha3 integrin and the activity of matrix metalloproteinase-2
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additional information
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LOX propeptide expression in Her-2/neu-driven breast cancer cells in culture suppresses Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB activation
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additional information
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not inhibited by berenil
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additional information
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not inhibited by berenil
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additional information
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TNF-alpha-stimulated matrix metalloproteinase-9 expression and Erk1/2 activation are both significantly inhibited by LOX-PP
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additional information
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hypercholesterolemia down-regulates LOX expression and activity
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additional information
alkylamino derivatives of 4-aminomethylpyridine, substrate-like, reversible inhibitors
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additional information
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hypercholesterolemia down-regulates LOX expression and activity
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