1.4.3.1: D-aspartate oxidase

This is an abbreviated version!
For detailed information about D-aspartate oxidase, go to the full flat file.

Word Map on EC 1.4.3.1

1.4.3.1

d-amino

n-methyl-d-aspartate

nmda

d-serine

d-glutamate

octopus

nmdar-dependent

d-alanine

prepulse

humicola

d-amino-acid

d-ser

d-glu

drug development

molecular biology

medicine

Reaction

Synonyms

aspartic oxidase, C47A10.5 gene product, C47Ap, ChDASPO, ChDDO, D-Asp oxidase, D-aspartic oxidase, D-AspO, DAO, DASOX, DASPO, DDO, DDO-1, DDO-2, DDO-3, DDO1, DDO3, F18E3.7a gene product, F18Ep

ECTree

1 Oxidoreductases

1.4 Acting on the CH-NH₂ group of donors

1.4.3 With oxygen as acceptor

1.4.3.1 D-aspartate oxidase

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Results	in table
2	Activating Compound
342	AA Sequence
4	Application
1	CAS Registry Number
32	Cloned(Commentary)
61	Cofactor
2	Crystallization (Commentary)
3	Disease/ Diagnostics
2	Expression
16	General Information
1	General Stability
38	IC50 Value
133	Inhibitors
51	kcat/KM [mM/s]
21	Ki Value [mM]
153	KM Value [mM]
42	Localization
1	Metals/Ions
30	Molecular Weight [Da]
114	Natural Substrates/ Products (Substrates)
294	Organism
5	Pathway
6	PDB ID
14	pH Optimum
6	pH Range
5	pH Stability
35	Protein Variants
27	Purification (Commentary)
1	Reaction
3	Reaction Type
117	Reference
191	Source Tissue
68	Specific Activity [micromol/min/mg]
1	Storage Stability
338	Substrates and Products (Substrate)
25	Subunits
89	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
8	Temperature Stability [°C]
70	Turnover Number [1/s]

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Application on EC 1.4.3.1 - D-aspartate oxidase

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drug development

2 entries

medicine

Homo sapiens

Q99489

the additional N-terminal peptide present in the DASPO_369 splicing isoform only has been identified in hippocampus of Alzheimer's disease female patients, while peptides corresponding to the remaining part of the protein are present in samples from male and female healthy controls and Alzheimer's disease patients. Upon expression in U87 human glioblastoma cells, the DASPO_369 protein shows a lower expression compared with the canonical isoform. Both protein isoforms are active, localize to the peroxisomes, are very stable, and are primarily degraded through the ubiquitin-proteasome system

763024

molecular biology

Homo sapiens

This enzyme is proposed to have a role in the inactivation of the synaptically released D-aspartate. Its C-terminus has a peroxisome targeting signal.

391709