1.4.1.B4: carboxynorspermidine dehydrogenase
This is an abbreviated version!
For detailed information about carboxynorspermidine dehydrogenase, go to the full flat file.
Reaction
Synonyms
C-NSPD synthase, CANSDH, carboxynorspermidine synthase
ECTree
1.4.1.B4 carboxynorspermidine dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.4.1.B4 - carboxynorspermidine dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
carboxynorspermidine + NAD+ + H2O
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADH + H+
carboxynorspermidine + NADP+ + H2O
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+
carboxynorspermidine + NADP+ + H2O
-
-
-
?
carboxynorspermidine + NAD+ + H2O
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADH + H+
-
NADH is a much poorer cofactor than NADPH
-
-
ir
carboxynorspermidine + NAD+ + H2O
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADH + H+
-
NADH is a much poorer cofactor than NADPH
-
-
ir
carboxynorspermidine + NADP+ + H2O
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+
-
i.e. (3-((3-aminopropyl)amino)propyl)carbamate, incubation of the purified enzyme in the range of pH 6-8, with cofactor NADP+ or NAD+ concentrations up to 5 mM and substrate concentrations of carboxynorspermidine up to 10 mM, no reversible activity is observed
i.e. (2S)-2-amino-4-oxobutanoate
-
ir
carboxynorspermidine + NADP+ + H2O
L-aspartic 4-semialdehyde + 1,3-diaminopropane + NADPH + H+
-
i.e. (3-((3-aminopropyl)amino)propyl)carbamate, incubation of the purified enzyme in the range of pH 6-8, with cofactor NADP+ or NAD+ concentrations up to 5 mM and substrate concentrations of carboxynorspermidine up to 10 mM, no reversible activity is observed
i.e. (2S)-2-amino-4-oxobutanoate
-
ir
carboxyspermidine + NADP+ + H2O
L-aspartic 4-semialdehyde + putrescine + NADPH + H+
-
i.e. 3-[(4-aminobutyl)amino]-L-alanine, slightly active with putrescine, ca. 7% of the rate compared to 1,3-diaminopropane
-
-
ir
carboxyspermidine + NADP+ + H2O
L-aspartic 4-semialdehyde + putrescine + NADPH + H+
-
i.e. 3-[(4-aminobutyl)amino]-L-alanine, slightly active with putrescine, ca. 7% of the rate compared to 1,3-diaminopropane
-
-
ir
additional information
?
-
-
no activity with ethylenediamine, cadaverine, and D-aspartic beta-semialdehyde
-
-
?
additional information
?
-
-
no activity with ethylenediamine, cadaverine, and D-aspartic beta-semialdehyde
-
-
?
