1.4.1.9: leucine dehydrogenase

This is an abbreviated version!
For detailed information about leucine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.9

Reaction

L-leucine
+
H2O
+
NAD+
=
4-methyl-2-oxopentanoate
+
NH3
+
NADH
+
H+

Synonyms

dehydrogenase, leucine, L-leucine dehydrogenase, L-leucine:NAD+ oxidoreductase, deaminating, LeuDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.9 leucine dehydrogenase

pH Optimum

pH Optimum on EC 1.4.1.9 - leucine dehydrogenase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10.3
-
oxidative deamination of L-Leu in presence of 1.0 M NaCl
10.5 - 10.8
-
oxidative deamination of L-Leu and L-Val, phosphopyridoxylated enzyme
8.5
-
reductive amination of 2-oxopentanoate and 3-methyl-2-oxobutanoate
8.6
-
reductive amination of 3-methyl-2-oxobutanoate and 2-oxopentanoate
8.8
-
reductive amination of 3-methyl-2-oxobutanoate
9 - 9.5
additional information
-
pH-optima for the chimeric enzyme consisting of an amino-terminal domain of phenylalanine dehydrogenase and a carboxy-terminal domain of leucine dehydrogenase