1.4.1.8: valine dehydrogenase (NADP+)
This is an abbreviated version!
For detailed information about valine dehydrogenase (NADP+), go to the full flat file.
Reaction
Synonyms
dehydrogenase, valine (nicotinamide adenine dinucleotide phosphate), ValDH, valine dehydrogenase (nicotinamide adenine dinucleotide phosphate), VDH
ECTree
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Inhibitors
Inhibitors on EC 1.4.1.8 - valine dehydrogenase (NADP+)
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pyridoxal 5'-phosphate
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40% loss of activity, forms Schiff base with a lysine residue
additional information
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no inhibition by nucleotide mono-, di-, triphosphates or the free bases adenine, cytosine, thymine, guanine and uracil
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Hg2+
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HgCl2: strong inhibition, partially abolished in presence of 2-mercaptoethanol
L-valine
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VDH2: 20 mM instead of 10 mM in reaction mixture caused 22% loss of activity, 50 mM 40% loss of activity
p-chloromercuribenzoate
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strong inhibition, partially abolished in presence of 2-mercaptoethanol