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1.4.1.7: serine 2-dehydrogenase

This is an abbreviated version!
For detailed information about serine 2-dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.7

Reaction

L-serine
+
H2O
+
NAD+
=
3-hydroxypyruvate
+
NH3
+
NADH
+
H+

Synonyms

L-serine:NAD oxidoreductase (deaminating), NAD+-dependent L-serine dehydrogenase, protein PA0743, serine dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.7 serine 2-dehydrogenase

Engineering

Engineering on EC 1.4.1.7 - serine 2-dehydrogenase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D247A
-
site-directed mutagenesis, inactive mutant
E122A
-
site-directed mutagenesis, the mutant shows alterations in cofactor binding and highly reduced activity compared to the wild-type enzyme
K171A
-
site-directed mutagenesis, inactive mutant
K246A
-
site-directed mutagenesis, inactive mutant
N175A
-
site-directed mutagenesis, the mutant shows alterations in cofactor binding and highly reduced activity compared to the wild-type enzyme
T96A
-
site-directed mutagenesis, the mutant shows alterations in cofactor binding and highly reduced activity compared to the wild-type enzyme
W214A
-
site-directed mutagenesis, inactive mutant
Y219A
-
site-directed mutagenesis, the mutant shows alterations in cofactor binding and highly reduced activity compared to the wild-type enzyme
additional information
-
PA0743 deletion (PW2350) strain from a transposon library