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BRENDA support

1.4.1.3: glutamate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about glutamate dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

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L-glutamate
+
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H2O
+
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NAD(P)+
=
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2-oxoglutarate
+
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NH3
+
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NAD(P)H
+
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H+

Synonyms

At5g07440, At5g18170, dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)), dual-coenzyme specific glutamate dehydrogenase, GDH, gdh-1, GDH1, GDH2, GDH3, GdhA, gdhA_1, GDHB, GDHII, GLDH, GLUD1, GLUD2, GluDH, glutamate dehydrogenase, glutamate dehydrogenase 1, glutamate dehydrogenase 2, glutamic acid dehydrogenase, glutamic dehydrogenase, hGDH1, hGDH2, hGLUD1, hGLUD2, housekeeping glutamate dehydrogenase, L-glutamate dehydrogenase, L-glutamic acid dehydrogenase, Legdh1, Membrane protein 50, MP50, NAD(P)+-dependent glutamate dehydrogenase, NAD(P)-dependent GDH, NAD(P)-dependent glutamate dehydrogenase, NAD(P)-glutamate dehydrogenase, NAD(P)H-dependent glutamate dehydrogenase, NAD(P)H-utilizing glutamate dehydrogenase, NADH-GDH, NADH-glutamate dehydrogenase, TTC1211, TTC1212, TtGDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                EC 1.4.1.31.4.1.3 glutamate dehydrogenase [NAD(P)+]

Specific Activity

Specific Activity on EC 1.4.1.3 - glutamate dehydrogenase [NAD(P)+]

for references in articles please use BRENDA:EC1.4.1.3

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00076
-
activity in liver nuclei, cofactor NADH
0.0028
-
activity in liver mitochondria, cofactor NADH
0.168
-
NADH dependent activity in cells grown on medium containing 1 mM NH4Cl
0.257
-
NADH dependent activity in cells grown on medium containing 1 mM NH4Cl
0.336
-
NADH dependent activity in cells grown on medium containing 1 mM NH4Cl
0.36
-
cofactor NADPH
0.858
-
NADPH dependent activity in cells grown on medium containing 1 mM NH4Cl
1.07
-
NADH dependent activity in cells grown on medium containing 1 mM NH4Cl
1.2
-
glutamate dehydrogenase 2
1.8
-
glutamate dehydrogenase 1
1.93
-
after 3rd crystallization
1.96
-
NADPH dependent activity in cells grown on medium containing 1 mM NH4Cl
100
-
recombinant R463A mutant enzyme, maximal activity in the presence of 6 mM leucine
126.4
-
cofactor NADH
13
-
cofactor NADH
140
-
recombinant H454Y mutant enzyme, maximal activity in the presence of 0.2 mM ADP
145.7
-
purified mutant enzyme R443S/G456A
159.1
-
purified isozyme GDH2
161.9
-
purified isozyme GDH1
17.8
-
liver enzyme
19
-
recombinant S448P mutant enzyme, basal activity
190
-
enzyme from euthermic animals
2.22
-
NADPH dependent activity in cells grown on medium containing 1 mM NH4Cl
201
-
enzyme from hibernating animals
3.5
-
cofactor NADH
32.3
-
high-activity form of the enzyme, NADP+-dependent deamination
32.5
-
at 85┬░C
34
-
liver enzyme
4
-
cofactor NADPH
4.6
-
membrane-bound liver enzyme
4.8
-
enzyme purified from liver nuclei
411
-
native enzyme at 100┬░C
419
-
recombinant enzyme at 75┬░C
5.18
-
NADPH dependent activity in cells grown on medium containing 1 mM NH4Cl
5.9
-
low-activity form of the enzyme, NADP+ dependent deamination
55
-
recombinant S448P mutant enzyme, maximal activity in the presence of 6 mM leucine
69
-
recombinant S448P mutant enzyme, maximal activity in the presence of 0.2 mM ADP
73
-
recombinant R463A mutant enzyme, basal activity
74
-
recombinant H454Y mutant enzyme, basal activity
79.4
-
purified enzyme, pH 8.0, 70┬░C
84
-
recombinant wild-type enzyme, basal activity
additional information