1.4.1.3: glutamate dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about glutamate dehydrogenase [NAD(P)+], go to the full flat file.
Reaction
+
+
=
+
+
+
Synonyms
At5g07440, At5g18170, dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate)), dual-coenzyme specific glutamate dehydrogenase, GDH, gdh-1, GDH1, GDH2, GDH3, GdhA, gdhA_1, GDHB, GDHII, GLDH, GLUD1, GLUD2, GluDH, glutamate dehydrogenase, glutamate dehydrogenase 1, glutamate dehydrogenase 2, glutamic acid dehydrogenase, glutamic dehydrogenase, hGDH1, hGDH2, hGLUD1, hGLUD2, housekeeping glutamate dehydrogenase, L-glutamate dehydrogenase, L-glutamic acid dehydrogenase, Legdh1, Membrane protein 50, MP50, NAD(P)+-dependent glutamate dehydrogenase, NAD(P)-dependent GDH, NAD(P)-dependent glutamate dehydrogenase, NAD(P)-glutamate dehydrogenase, NAD(P)H-dependent glutamate dehydrogenase, NAD(P)H-utilizing glutamate dehydrogenase, NADH-GDH, NADH-glutamate dehydrogenase, TTC1211, TTC1212, TtGDH
ECTree
KI Value
KI Value on EC 1.4.1.3 - glutamate dehydrogenase [NAD(P)+]
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0.315 - 70
2-oxoglutarate
0.005
8-azidoguanosine 5'-triphosphate
-
-
0.76
ATP
-
inhibition of microtubules to membrane-bound liver enzyme
0.00036 - 0.0051
diethylstilbestrol
6.1
histidine
-
at pH 10.0
0.03 - 0.1
o-phthalaldehyde
0.000013 - 0.0002
palmitoyl-CoA
0.0009 - 0.061
phosphatidylserine
-
-
0.315
2-oxoglutarate
-
-
2.6
2-oxoglutarate
-
liver enzyme
5
2-oxoglutarate
-
kidney enzyme
60
2-oxoglutarate
-
substrate inhibition vs. NADPH
70
2-oxoglutarate
-
substrate inhibition vs. NH4+
6.2
alanine
-
at pH 10.0
0.00036
diethylstilbestrol
-
inhibition of recombinant H454Y mutant enzyme
0.00074
diethylstilbestrol
-
inhibition of recombinant S448P mutant enzyme
0.0017
diethylstilbestrol
-
inhibition of recombinant wild-type enzyme
0.0051
diethylstilbestrol
-
inhibition of recombinant R463A mutant enzyme
1.1
glutamate
-
at pH 10.0
4.1
glutamate
-
at pH 8.5
0.07
Glutarate
-
at pH 8.5
0.09
Glutarate
-
at pH 7.4
0.000042
GTP
-
inhibition of recombinant wild-type enzyme
0.00022
GTP
-
inhibition of recombinant R463A mutant enzyme
0.00156
GTP
molar ratio pyridoxamine 5'-phosphate-form of the mitochondrial branched chain aminotransferase (PMP-BCATm)/GDH1: 1
0.0031
GTP
-
inhibition of recombinant S448P mutant enzyme
0.00312
GTP
molar ratio pyridoxamine 5'-phosphate-form of the mitochondrial branched chain aminotransferase (PMP-BCATm)/GDH1: 2
0.0065
GTP
-
1 mM NAD+ or 80 mM NADH
0.00795
GTP
molar ratio pyridoxamine 5'-phosphate-form of the mitochondrial branched chain aminotransferase (PMP-BCATm)/GDH1: 6
0.00806
GTP
molar ratio pyridoxamine 5'-phosphate-form of the mitochondrial branched chain aminotransferase (PMP-BCATm)/GDH1: 4
0.012
GTP
-
0.016 mM NADH
0.21
GTP
-
inhibition of recombinant H454Y mutant enzyme
0.686
L-glutamate
pH and temperature not specified in the publication
80
L-glutamate
-
reductive amination with NADPH, not with NADH is inhibited
3.7
lysine
-
at pH 10.0
0.011
NADH
-
liver enzyme
0.016
NADH
-
kidney enzyme
46
NH4Cl
-
liver enzyme
0.03
o-phthalaldehyde
-
vs. 2-oxoglutarate
0.1
o-phthalaldehyde
-
vs. NADH
0.36
oxalylglycine
-
vs. 2-oxoglutarate
0.54
oxalylglycine
-
vs. NADPH
0.9
oxalylglycine
-
vs. NH4+
0.000013
palmitoyl-CoA
-
inhibition of recombinant S448P mutant enzyme
0.000015
palmitoyl-CoA
-
inhibition of recombinant H454Y mutant enzyme
0.00003
palmitoyl-CoA
-
inhibition of recombinant wild-type enzyme
0.0002
palmitoyl-CoA
-
inhibition of recombinant R463A mutant enzyme
5
Phenylglyoxal
-
vs. 2-oxoglutarate
6
Phenylglyoxal
-
vs. NADH