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0.0015 - 0.0692
17beta-estradiol
0.001 - 0.0032
corticosterone
0.0072 - 0.396
dehydroepiandrosterone
0.0494 - 0.814
dehydrotestosterone
0.001 - 0.008
diethylstilbestrol
0.0117 - 0.287
pregnenolone
0.0123 - 0.596
progesterone
0.0015
17beta-estradiol
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0151
17beta-estradiol
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.0269
17beta-estradiol
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0692
17beta-estradiol
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.05
Chloroquine
Homo sapiens
-
GDH1
0.14
Chloroquine
Homo sapiens
-
GDH2
0.001
corticosterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0021
corticosterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0025
corticosterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.0032
corticosterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.0072
dehydroepiandrosterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0294
dehydroepiandrosterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.216
dehydroepiandrosterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.396
dehydroepiandrosterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.0494
dehydrotestosterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0915
dehydrotestosterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.494
dehydrotestosterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.814
dehydrotestosterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.001
diethylstilbestrol
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.00167
diethylstilbestrol
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0071
diethylstilbestrol
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.008
diethylstilbestrol
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0113
estriol
Homo sapiens
pH 8.0, temperature not specified in the publication
0.145
estriol
Homo sapiens
pH 8.0, temperature not specified in the publication
0.189
estriol
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.316
estriol
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.00017
GTP
Homo sapiens
inhibition of wild-type enzyme and mutant enzymes r470H and N498S. No inhibition of mutant enzyme G456A. IC50 of mutant enzyme R470G is 0.00017 mM, IC50 of mutant enzyme N49
0.00019
GTP
Homo sapiens
potent inhibitor. IC50 for wild-type enzyme is 0.00019 mM
0.00019
GTP
Homo sapiens
inhibition of wild-type enzyme and mutant enzymes r470H and N498S. No inhibition of mutant enzyme G456A. IC50 of wild-type enzyme is 0.00019 mM
0.00031
GTP
Homo sapiens
-
in the absence of other modulators, pH 8.0
0.001
GTP
Homo sapiens
-
isozyme GDH1
0.00161
GTP
Homo sapiens
-
in the presence of 0.1 mM ADP, pH 8.0
0.0028
GTP
Homo sapiens
IC50 of mutant enzyme G456A is 0.0028 mM
0.0028
GTP
Homo sapiens
IC50 for mutant enzyme G456A is 0.0028 mM. ADP renders the GLUD1-derived enzyme less sensitive to GTP inhibition
0.0106
GTP
Mus musculus
C-terminally FLAG-tagged recombinant protein, pH 8.0, 23°C
0.0108
GTP
Homo sapiens
-
IC50 for mutant enzyme S331T: 0.0108 mM
0.0113
GTP
Homo sapiens
-
IC50 for mutant enzyme M370L: 0.0113 mM
0.0122
GTP
Homo sapiens
-
IC50 for wild-type GLUD1: 0.0122 mM
0.0147
GTP
Homo sapiens
-
IC50 for mutant enzyme M415L: 0.0147 mM
0.0162
GTP
Homo sapiens
-
IC50 for mutant enzyme R443S: 0.0162 mM
0.0185
GTP
Homo sapiens
-
in the presence of 1 mM ADP, pH 8.0
0.0196
GTP
Homo sapiens
His-tagged recombinant protein, pH 8.0, 23°C
0.0212
GTP
Homo sapiens
wild-type, pH 8.0, 23°C
0.0239
GTP
Homo sapiens
-
in the presence of 0.1 mM ADP, pH 8.0
0.0245
GTP
Mus musculus
wild-type, pH 8.0, 23°C
0.0271
GTP
Mus musculus
N-terminally FLAG-tagged recombinant protein, pH 8.0, 23°C
0.07
GTP
Homo sapiens
-
isozyme GDH2
0.0785
GTP
Homo sapiens
-
in the absence of other modulators, pH 8.0
0.1668
GTP
Homo sapiens
-
in the presence of 1 mM ADP, pH 8.0
0.186
GTP
Homo sapiens
-
mutant S448P, pH 8.0, 25°C
0.227
GTP
Homo sapiens
-
mutant Q441R, pH 8.0, 25°C
0.242
GTP
Homo sapiens
wild-type, pH 8.0, 23°C
0.25
GTP
Homo sapiens
His-tagged recombinant protein, pH 8.0, 23°C
0.2627
GTP
Homo sapiens
-
wild-type, pH 8.0, 25°C
0.31
GTP
Homo sapiens
-
GDH1, in the absence of ADP, in 50 mM triethanolamine pH 8.0 buffer
0.317
GTP
Homo sapiens
-
mutant S445L, pH 8.0, 25°C
2.921
GTP
Homo sapiens
-
mutant H454Y, pH 8.0, 25°C
18.5
GTP
Homo sapiens
-
GDH1, in the presence of 1 mM ADP, in 50 mM triethanolamine pH 8.0 buffer
78.5
GTP
Homo sapiens
-
GDH2, in the absence of ADP, in 50 mM triethanolamine pH 8.0 buffer in 50 mM TRA pH 8.0 buffer
139.4
GTP
Homo sapiens
-
mutant enzyme R443S/G456A, in the absence of ADP, in 50 mM triethanolamine pH 8.0 buffer
166.8
GTP
Homo sapiens
-
GDH2, in the presence of 1 mM ADP, in 50 mM triethanolamine pH 8.0 buffer
180
GTP
Homo sapiens
-
mutant K450E, pH 8.0, 25°C
622.4
GTP
Homo sapiens
-
mutant enzyme R443S/G456A, in the absence of ADP, in 50 mM triethanolamine pH 8.0 buffer
0.0117
pregnenolone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0541
pregnenolone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.104
pregnenolone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.287
pregnenolone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.0123
progesterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.0589
progesterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication
0.119
progesterone
Homo sapiens
pH 8.0, temperature not specified in the publication
0.596
progesterone
Homo sapiens
presence of 0.1 M ADP, pH 8.0, temperature not specified in the publication