1.4.1.28: secondary-alkyl amine dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about secondary-alkyl amine dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

Synonyms

AMDH, AmDH4, amine dehydrogenase, D187_009359, DapB_1, NAD+-dependent amine dehydrogenase, Pmob_1166

ECTree

1 Oxidoreductases

1.4 Acting on the CH-NH₂ group of donors

1.4.1 With NAD⁺ or NADP⁺ as acceptor

1.4.1.28 secondary-alkyl amine dehydrogenase [NAD(P)+]

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
8	AA Sequence
3	Application
1	Cloned(Commentary)
19	Cofactor
3	Crystallization (Commentary)
1	General Information
11	Inhibitors
29	kcat/KM [mM/s]
11	Ki Value [mM]
39	KM Value [mM]
2	Localization
1	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
23	Organism
9	pH Optimum
4	Protein Variants
4	Purification (Commentary)
1	Reaction
21	Reference
84	Specific Activity [micromol/min/mg]
1	Storage Stability
225	Substrates and Products (Substrate)
3	Subunits
23	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
2	Temperature Range [°C]
7	Temperature Stability [°C]
27	Turnover Number [1/s]

Crystallization

print visible entries

print all entries

Crystallization on EC 1.4.1.28 - secondary-alkyl amine dehydrogenase [NAD(P)+]

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Crystallization (commentary) Search

homology modeling of structure in complex with NADH. Residue S68 of AmDH forms a hydrogen bond with the substrate hydroxyl group, and there are also hydrophobic interactions between the substrate and the side chains of V116 and L261

Geobacillus stearothermophilus

P13154

764412

homology modeling of structure. The coordination of the amine group to E108 holds the tetrahedral carbon of the substrate bearing the amine

Laribacter hongkongensis

762848

structure without substrate but bound to the cofactor NAD+, and a model of the ternary complex with product (2R,4S)-2,4-diaminopentanoate in the closed conformation. The active site features residues Glu102, Val134, Asn135, Arg161, Asn163, Phe168, Val172, Gln176, His197, Ile198, His264, Gln266, Gly299 and Thr303

Petrotoga mobilis

A9BHL2

763489