1.4.1.28: secondary-alkyl amine dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about secondary-alkyl amine dehydrogenase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
AMDH, AmDH4, amine dehydrogenase, D187_009359, DapB_1, NAD+-dependent amine dehydrogenase, Pmob_1166
ECTree
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Application
Application on EC 1.4.1.28 - secondary-alkyl amine dehydrogenase [NAD(P)+]
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synthesis
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reductive amination of cyclohexanone (up to 100 mM) into cyclohexylamine is performed with an AmDH and formate dehydrogenase system with more than 99% conversion using Escherichia coli whole cell as well as purified enzymes. Chiral amine are produced from the corresponding ketone using inexpensive ammonium formate as sole sacrificial agent and enzymes omega-transaminase, AmDH, and formate dehydrogenase
synthesis
in the asymmetric amination of a series of structurally different hydroxy ketones, high stereoselectivity (above >99%) is achieved the reduction of aliphatic and aromatic compounds. The aliphatic substrates 1-hydroxy-4-methylpentan-2-one and 1-hydroxyhexan-2-one are aminated with 99% conversions
synthesis
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reductive amination of cyclohexanone (up to 100 mM) into cyclohexylamine using transgenic Escherichia coli as whole-cell reactors as well as purified enzymes