1.4.1.27: glycine cleavage system
This is an abbreviated version!
For detailed information about glycine cleavage system, go to the full flat file.
Word Map on EC 1.4.1.27
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1.4.1.27
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hyperglycinemia
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nonketotic
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h-protein
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lipoic
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lipoylation
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one-carbon
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encephalopathy
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hydroxymethyltransferase
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lipoate
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dihydrolipoamide
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alpha-keto
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octanoylation
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2-oxoacids
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aminomethyltransferase
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5,10-methylenetetrahydrofolate
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dextromethorphan
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lipoyltransferase
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aminomethyl
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alpha-ketoacids
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1-carbon
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flaveria
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dimethylglycine
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medicine
-
synthesis
- 1.4.1.27
- hyperglycinemia
-
nonketotic
- h-protein
-
lipoic
-
lipoylation
-
one-carbon
- encephalopathy
- hydroxymethyltransferase
- lipoate
- dihydrolipoamide
-
alpha-keto
-
octanoylation
- 2-oxoacids
- aminomethyltransferase
- 5,10-methylenetetrahydrofolate
- dextromethorphan
- lipoyltransferase
-
aminomethyl
- alpha-ketoacids
-
1-carbon
- flaveria
- dimethylglycine
- medicine
- synthesis
Reaction
Synonyms
Amt, At1g11860, At1g32470, At1g48030, AT2G35370, At4g33010, DLD, DLDH, GCSH, GCV, GcvH, GcvP, GCVT, GDCSH, GDCSP, GDH1, GDSCT, GLDC, glycine cleavage complex, H-protein, LpdA, P-protein, sll0171, slr1096, T-protein
ECTree
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Metals Ions
Metals Ions on EC 1.4.1.27 - glycine cleavage system
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Co2+
0.1 mM, 83% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein)
Cu2+
0.1 mM, 100% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein). Of the two partial reactions, decarboxylation of glycine yielding the H-protein-bound aminomethyl moiety is not significantly affected, but carboxylation of the H-protein-bound aminomethyl moiety to form glycine is strongly inhibited
Fe2+
0.1 mM, 20% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein)
Ni2+
0.1 mM, 84% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein)
Zn2+
0.1 mM, 99% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein), competitive with both bicarbonate and H-protein and noncompetitive with glycine. Of the two partial reactions, decarboxylation of glycine yielding the H-protein-bound aminomethyl moiety is not significantly affected, but carboxylation of the H-protein-bound aminomethyl moiety to form glycine is strongly inhibited
additional information
additional information
no significant inhibition: Mn2+, Mg2+