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1.4.1.27: glycine cleavage system

This is an abbreviated version!
For detailed information about glycine cleavage system, go to the full flat file.

Word Map on EC 1.4.1.27

Reaction

glycine
+
tetrahydrofolate
+
NAD+
=
5,10-methylenetetrahydrofolate
+
NH3
+
CO2
+
NADH

Synonyms

Amt, At1g11860, At1g32470, At1g48030, AT2G35370, At4g33010, DLD, DLDH, GCSH, GCV, GcvH, GcvP, GCVT, GDCSH, GDCSP, GDH1, GDSCT, GLDC, glycine cleavage complex, H-protein, LpdA, P-protein, sll0171, slr1096, T-protein

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.27 glycine cleavage system

Metals Ions

Metals Ions on EC 1.4.1.27 - glycine cleavage system

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Co2+
P15505, P15505; P11183; P28337
0.1 mM, 83% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein)
Cu2+
P15505, P15505; P11183; P28337
0.1 mM, 100% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein). Of the two partial reactions, decarboxylation of glycine yielding the H-protein-bound aminomethyl moiety is not significantly affected, but carboxylation of the H-protein-bound aminomethyl moiety to form glycine is strongly inhibited
Fe2+
P15505, P15505; P11183; P28337
0.1 mM, 20% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein)
Ni2+
P15505, P15505; P11183; P28337
0.1 mM, 84% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein)
Zn2+
P15505, P15505; P11183; P28337
0.1 mM, 99% inhibition of the exchange of glycine carboxyl carbon with CO, catalyzed by glycine decarboxylase (P-protein) and aminomethyl carrier protein (H-protein), competitive with both bicarbonate and H-protein and noncompetitive with glycine. Of the two partial reactions, decarboxylation of glycine yielding the H-protein-bound aminomethyl moiety is not significantly affected, but carboxylation of the H-protein-bound aminomethyl moiety to form glycine is strongly inhibited
additional information