1.4.1.24: 3-dehydroquinate synthase II

This is an abbreviated version!
For detailed information about 3-dehydroquinate synthase II, go to the full flat file.

Word Map on EC 1.4.1.24

Reaction

2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
+
H2O
+
NAD+
=
3-dehydroquinate
+
NH3
+
NADH
+
H+

Synonyms

aroB', aroB2, dehydroquinate synthase II, DHQ synthase, DHQ synthase II, DHQS, MJ1249, MJ1249 protein, type II 3-dehydroquinate synthase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.24 3-dehydroquinate synthase II

Systematic Name

Systematic Name on EC 1.4.1.24 - 3-dehydroquinate synthase II

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SYSTEMATIC NAME
IUBMB Comments
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate:NAD+ oxidoreductase (deaminating)
The enzyme, which was isolated from the archaeon Methanocaldococcus jannaschii, plays a key role in an alternative pathway for the biosynthesis of 3-dehydroquinate (DHQ), an intermediate of the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme catalyses a two-step reaction - an oxidative deamination, followed by cyclization.