1.4.1.21: aspartate dehydrogenase

This is an abbreviated version!
For detailed information about aspartate dehydrogenase, go to the full flat file.

Reaction

Synonyms

AspDH, L-aspartate dehydrogenase, L-aspartate:NAD(P)+ oxidoreductase (deaminating), L-aspDH, NAD-dependent aspartate dehydrogenase, NADH2-dependent aspartate dehydrogenase, NADP+-dependent aspartate dehydrogenase, nadX

ECTree

     1 Oxidoreductases

         1.4 Acting on the CH-NH₂ group of donors

             1.4.1 With NAD⁺ or NADP⁺ as acceptor

                1.4.1.21 aspartate dehydrogenase

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Results	in table
1	Activating Compound
4875	AA Sequence
19	Application
1	CAS Registry Number
14	Cloned(Commentary)
58	Cofactor
2	Crystallization (Commentary)
31	General Information
2	General Stability
4	Inhibitors
26	kcat/KM [mM/s]
2	Ki Value [mM]
74	KM Value [mM]
14	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
54	Organism
4	Pathway
2	PDB ID
19	pH Optimum
2	pH Range
4	pH Stability
4	Protein Variants
9	Purification (Commentary)
3	Reaction
3	Reaction Type
25	Reference
20	Specific Activity [micromol/min/mg]
1	Storage Stability
110	Substrates and Products (Substrate)
29	Subunits
44	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
3	Temperature Range [°C]
22	Temperature Stability [°C]
34	Turnover Number [1/s]

KM Value

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KM Value on EC 1.4.1.21 - aspartate dehydrogenase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.067 - 1.2

L-Asp

2 entries

0.067 - 27

L-aspartate

18 entries

0.11 - 10

NAD+

11 entries

0.014 - 4.5

NADH

9 entries

0.102 - 7.43

NADP+

11 entries

0.032 - 0.21

NADPH

4 entries

4.3 - 167

NH3

8 entries

167

NH4+

Archaeoglobus fulgidus

-

-

672387

1.2 - 21

oxaloacetate

9 entries

additional information

additional information

Pseudomonas aeruginosa

-

Michaelis-Menten kinetics

724055

-

0.067

L-Asp

Thermotoga maritima

Q9X1X6

cofactor NAD+

654027

1.2

L-Asp

Thermotoga maritima

Q9X1X6

cofactor: NADP+

654027

0.067

L-aspartate

Thermotoga maritima

Q9X1X6

+/- 0.008, with NAD+

654027

0.067

L-aspartate

Thermotoga maritima

-

pH and temperature not specified in the publication, with NAD+

724068

0.19

L-aspartate

Archaeoglobus fulgidus

-

with NAD+ as the electron acceptor

672387

0.19

L-aspartate

Cupriavidus necator

-

pH 10.2, 37°C, with NAD+

724068

0.19

L-aspartate

Cupriavidus necator

Q46VA0

pH 10.2, 37°C, with NAD+

724591

1.2

L-aspartate

Thermotoga maritima

Q9X1X6

+/- 0.05, with NADP+

654027

1.2

L-aspartate

Thermotoga maritima

-

pH and temperature not specified in the publication, with NADP+

724068

2.3

L-aspartate

Archaeoglobus fulgidus

-

pH 11.6, 50°C, with NAD+

724068

4.3

L-aspartate

Archaeoglobus fulgidus

-

with NADP+ as the electron acceptor

672387

4.3

L-aspartate

Cupriavidus necator

-

pH 10.2, 37°C, with NADP+

724068

4.3

L-aspartate

Cupriavidus necator

Q46VA0

pH 10.2, 37°C, with NADP+

724591

4.74

L-aspartate

Pseudomonas aeruginosa

-

pH 9.8, 37°C, with NADP+

724055

4.74

L-aspartate

Pseudomonas aeruginosa

Q9HYA4

pH 9.8, 37°C, with NADP+

724068

4.87

L-aspartate

Pseudomonas aeruginosa

-

pH 9.8, 37°C, with NAD+

724055

4.87

L-aspartate

Pseudomonas aeruginosa

Q9HYA4

pH 9.8, 37°C, with NAD+

724068

13.4

L-aspartate

Rhodopseudomonas palustris

-

pH 9.8, 28°C, recombinant enzyme

723988

26.6

L-aspartate

Archaeoglobus fulgidus

-

pH 11.6, 50°C, with NADP+

724068

27

L-aspartate

Bradyrhizobium japonicum

-

pH 9.8, 28°C, recombinant enzyme

723988

0.11

NAD+

Archaeoglobus fulgidus

-

-

672387

0.11

NAD+

Cupriavidus necator

-

pH 10.2, 37°C

724068

0.11

NAD+

Cupriavidus necator

Q46VA0

pH 10.2, 37°C

724591

0.25

NAD+

Thermotoga maritima

Q9X1X6

-

654027

0.25

NAD+

Thermotoga maritima

Q9X1X6

+/- 0.02

654027

0.25

NAD+

Thermotoga maritima

-

pH and temperature not specified in the publication

724068

0.47

NAD+

Pseudomonas aeruginosa

-

pH 9.8, 37°C

724055

0.47

NAD+

Pseudomonas aeruginosa

Q9HYA4

pH 9.8, 37°C

724068

0.97

NAD+

Archaeoglobus fulgidus

-

pH 11.6, 50°C

724068

7

NAD+

Rhodopseudomonas palustris

-

pH 9.8, 28°C, recombinant enzyme

723988

10

NAD+

Bradyrhizobium japonicum

-

pH 9.8, 28°C, recombinant enzyme

723988

0.014

NADH

Archaeoglobus fulgidus

-

-

672387

0.014

NADH

Cupriavidus necator

Q46VA0

pH 8.2, 37°C

724591

0.014

NADH

Cupriavidus necator

-

pH not specified in the publication, 37°C

724068

0.042

NADH

Pseudomonas aeruginosa

-

pH 8.2, 37°C

763424

0.045

NADH

Pseudomonas aeruginosa

-

pH 8.2, 37°C

724055

0.045

NADH

Pseudomonas aeruginosa

Q9HYA4

pH 8.2, 37°C

724068

0.061

NADH

Archaeoglobus fulgidus

-

pH not specified in the publication, 50°C

724068

0.25

NADH

Bradyrhizobium japonicum

-

pH 9.0, 28°C, recombinant enzyme

723988

4.5

NADH

Rhodopseudomonas palustris

-

pH 9.0, 28°C, recombinant enzyme

723988

0.102

NADP+

Rhodopseudomonas palustris

-

pH 9.8, 28°C, recombinant enzyme

723988

0.12

NADP+

Bradyrhizobium japonicum

-

pH 9.8, 28°C, recombinant enzyme

723988

0.32

NADP+

Archaeoglobus fulgidus

-

-

672387

0.32

NADP+

Cupriavidus necator

-

pH 10.2, 37°C

724068

0.32

NADP+

Cupriavidus necator

Q46VA0

pH 10.2, 37°C

724591

0.47

NADP+

Pseudomonas aeruginosa

-

pH 9.8, 37°C

724055

0.47

NADP+

Pseudomonas aeruginosa

Q9HYA4

pH 9.8, 37°C

724068

0.72

NADP+

Thermotoga maritima

Q9X1X6

-

654027

0.72

NADP+

Thermotoga maritima

Q9X1X6

+/- 0.04

654027

0.72

NADP+

Thermotoga maritima

-

pH and temperature not specified in the publication

724068

7.43

NADP+

Archaeoglobus fulgidus

-

pH 11.6, 50°C

724068

0.032

NADPH

Bradyrhizobium japonicum

-

pH 9.0, 28°C, recombinant enzyme

723988

0.052

NADPH

Pseudomonas aeruginosa

-

pH 8.2, 37°C

724055

0.057

NADPH

Pseudomonas aeruginosa

-

pH 8.2, 37°C

763424

0.21

NADPH

Rhodopseudomonas palustris

-

pH 9.0, 28°C, recombinant enzyme

723988

4.3

NH3

Bradyrhizobium japonicum

-

pH 9.0, 28°C, recombinant enzyme

723988

10.1

NH3

Pseudomonas aeruginosa

-

pH 8.2, 37°C, with NADH

724055

10.1

NH3

Pseudomonas aeruginosa

Q9HYA4

pH 8.2, 37°C, with NADH

724068

11.3

NH3

Rhodopseudomonas palustris

-

pH 9.0, 28°C, recombinant enzyme

723988

12.7

NH3

Pseudomonas aeruginosa

-

pH 8.2, 37°C, with NADPH

724055

14.9

NH3

Archaeoglobus fulgidus

-

pH not specified in the publication, 50°C, with NADH

724068

167

NH3

Cupriavidus necator

Q46VA0

pH 8.2, 37°C, with NADH

724591

167

NH3

Cupriavidus necator

-

pH not specified in the publication, 37°C, with NADH

724068

1.2

oxaloacetate

Archaeoglobus fulgidus

-

-

672387

1.2

oxaloacetate

Cupriavidus necator

Q46VA0

pH 8.2, 37°C, with NADH

724591

1.2

oxaloacetate

Cupriavidus necator

-

pH not specified in the publication, 37°C, with NADH

724068

2.12

oxaloacetate

Pseudomonas aeruginosa

-

pH 8.2, 37°C, with NADH

724055

2.12

oxaloacetate

Pseudomonas aeruginosa

Q9HYA4

pH 8.2, 37°C, with NADH

724068

2.32

oxaloacetate

Archaeoglobus fulgidus

-

pH not specified in the publication, 50°C, with NADH

724068

3.14

oxaloacetate

Pseudomonas aeruginosa

-

pH 8.2, 37°C, with NADPH

724055

9.2

oxaloacetate

Rhodopseudomonas palustris

-

pH 9.0, 28°C, recombinant enzyme

723988

21

oxaloacetate

Bradyrhizobium japonicum

-

pH 9.0, 28°C, recombinant enzyme

723988