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1.4.1.20: phenylalanine dehydrogenase

This is an abbreviated version!
For detailed information about phenylalanine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.20

Reaction

L-phenylalanine
+
H2O
+
NAD+
=
phenylpyruvate
+
NH3
+
NADH
+
H+

Synonyms

dehydrogenase, phenylalanine, L-PheDH, L-phenylalanine dehydrogenase, L-phenylalanine:NAD+ oxidoreductase, deaminating, PDH, PHD, PheDH, phenylalanine dehydrogenase, recombinant PheDH, recombinant phenylalanine dehydrogenase

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.20 phenylalanine dehydrogenase

Turnover Number

Turnover Number on EC 1.4.1.20 - phenylalanine dehydrogenase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
26
2-oxo-4-methylpentanoate
-
wild-type enzyme
37
2-oxo-4-methylthiobutanoate
-
wild-type enzyme
79
2-Oxohexanoate
-
wild-type enzyme
57
2-Oxoisohexanoate
-
wild-type enzyme
82
2-oxopentanoate
-
wild-type enzyme
27
4-methyl-2-oxopentanoate
-
25°C, pH 10.4
0.72
4-phenyl-2-butanone
mutant enzyme K66Q/S149G/N262C, at pH 9.6 and 30°C
27
alpha-keto-gamma-methiobutyrate
-
25°C, pH 10.4
51
alpha-Ketocaproate
-
25°C, pH 10.4
33
alpha-ketovalerate
-
25°C, pH 10.4
7.2
DL-alpha-keto-beta-methyl-n-valerate
-
25°C, pH 10.4
0.5 - 1.82
DL-propargylglycine
0.1 - 1.1
L-ethionine
0.24 - 0.28
L-Ile
0.14
L-isoleucine
-
25°C, pH 10.4
0.21 - 3.6
L-Leu
0.7
L-leucine
-
25°C, pH 10.4
0.16 - 0.84
L-Met
1.2
L-methionine
-
25°C, pH 10.4
0.17 - 3.2
L-norleucine
0.15 - 1.4
L-norvaline
0.75 - 816
L-Phe
0.608 - 68.01
L-phenylalanine
26 - 68
L-tyrosine
0.91
L-valine
-
25°C, pH 10.4
90
p-hydroxy-phenylpyruvate
-
25°C, pH 10.4
0.7
phenylacetone
mutant enzyme K66Q/S149G/N262C, at pH 9.6 and 30°C
91 - 113
phenylpyruvate
additional information
additional information
-
turnover numbers of wild-type and mutant enzymes
-