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1.4.1.2: glutamate dehydrogenase

This is an abbreviated version!
For detailed information about glutamate dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.2

Reaction

L-glutamate
+
H2O
 +
NAD+
=
2-oxoglutarate
 +
NH3
 +
NADH
 +
H+

Synonyms

At5g18170, AtGDH1, BpNADGDH, c, CCNA_00086, CsGDH, dehydrogenase, glutamate, GDH, GDH isoenzyme 1, GDH, NAD-dependent, gdh-1, gdh-2, GDH1, GDH2, Gdh2p, GDH3, GdhA, GDHB, GDHI, GdhZ, Glu dehydrogenase, GluD, GLUD1, GLUD2, GluDH, glutamate dehydrogenase, glutamate dehydrogenase (NAD), glutamate dehydrogenase 2, glutamate dehydrogenase alpha subunit, glutamate dehydrogenase beta subunit, glutamate dehydrogenase isoform 1, glutamate oxidoreductase, glutamic acid dehydrogenase, glutamic dehydrogenase, hGDH1, hGDH2-nerve-specific GDH, house-keeping GDH, L-glutamate dehydrogenase, L-glutamic acid dehydrogenase, More, NAD(+)-dependent glutamate dehydrogenase, NAD(H)-dependent glutamate dehydrogenase, NAD+-dependant glutamate dehydrogenase, NAD+-dependent GDH, NAD+-dependent GDHX, NAD+-dependent GluDH, NAD+-dependent glutamate dehydrogenase, NAD+-GDH, NAD+-glutamate dehydrogenase, NAD+-specific GDH, NAD+-specific glutamate dehydrogenase, NAD-dependent GDH, NAD-dependent glutamate dehydrogenase, NAD-dependent glutamic dehydrogenase, NAD-dependent L-glutamate dehydrogenase, NAD-GDH, NAD-glutamate dehydrogenase, NAD-linked glutamate dehydrogenase, NAD-linked glutamic dehydrogenase, NAD-specific glutamate dehydrogenase, NAD-specific glutamic dehydrogenase, NAD-ylGdh2p, NAD:glutamate oxidoreductase, NADH-dependent GDH, NADH-dependent glutamate dehydrogenase, NADH-GDH, NADH-glutamate dehydrogenase, NADH-linked glutamate dehydrogenase, OsGDH1, OsGDH2, OsGDH3, Pcal_1031, RocG, sco2999, Surface-associated protein PGAG1, t-GDH, type I GDH, YALI0E09603g, ylGDH2

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.2 glutamate dehydrogenase

Activating Compound

Activating Compound on EC 1.4.1.2 - glutamate dehydrogenase

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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
acetonitrile
-
activates
Al3+
-
GDH is activated at 0.03-0.08 mM in the Tris-HCl buffer solution at pH 6.5 and 7.5
alkalized extract
-
asparagine
-
activates
aspartate
-
activates
ATP
-
activates in presence of 3 M NaCl or 3 M Kcl, slight activation in absence of salts
D-arginine
212% activity in the presence of 10 mM D-arginine
dAMP
-
stimulation
ethylene
glycerol
activates at 10%
guanidine hydrochloride
-
activates
H2O2
-
increase in the aminating GDH activity correlating with gene expression, in a dose-dependent manner
heating
-
at 90°C the activity of the recombinant enzyme increases to a level comparable to that of the native enzyme
-
isocitrate
10 M, 112% of initial activity
jasmonic acid
L-arginine
L-asparagine
L-aspartate
L-aspartic acid
-
-
L-cysteine
L-His
-
activates in presence of 3 M NaCl, 3 M Kcl or in absence of salts
L-histidine
L-isoleucine
-
-
L-Leu
-
activates in presence of 3 M NaCl, 3 M Kcl or in absence of salts
L-lysine
L-methionine
L-phenylalanine
-
-
L-tryptophan
leucine
-
stimulation
NaCl
-
high NaCl induces the formation of reactive oxygen species, which in turn induces the synthesis of the alpha-subunit of GDH
NaNO3
GDH1 transcripts slightly and slowly increase by 2fold after N nutrition addition while GDH2 mRNA is not affected
NH3
-
GDH is activated by excess ammonia
NH4Cl
rapid and marked increase in the accumulation of mRNAs for GDH1 and GDH2 after supply
NH4NO3
-
increases the NADH-GDH activity in the presence of Hg
protopine
salicylic acid
tetrahydrofuran
-
activates
Zn2+
224% activity in the presence of 1 mM Zn2+
additional information
-