1.4.1.16: diaminopimelate dehydrogenase
This is an abbreviated version!
For detailed information about diaminopimelate dehydrogenase, go to the full flat file.
Word Map on EC 1.4.1.16
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1.4.1.16
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glutamicum
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corynebacterium
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d-amino
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deamination
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thermophilum
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symbiobacterium
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l-lysine
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dihydrodipicolinate
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2-keto
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thermosphaericus
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ureibacillus
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isoxazoline
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homoserine
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sphaericus
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synthesis
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biotechnology
- 1.4.1.16
- glutamicum
- corynebacterium
-
d-amino
-
deamination
- thermophilum
- symbiobacterium
- l-lysine
- dihydrodipicolinate
-
2-keto
- thermosphaericus
-
ureibacillus
-
isoxazoline
- homoserine
- sphaericus
- synthesis
- biotechnology
Reaction
Synonyms
BAB07799, BF3690, DAPDH, DDH, meso-2,6-diaminopimelate dehydrogenase, meso-alpha,epsilon-diaminopimelate dehydrogenase, meso-DAPDH, meso-diaminopimelate dehydrogenase, NADP+-dependent meso-diaminopimelate dehydrogenase, Sth1425, Theth_1310
ECTree
1.4.1.16 diaminopimelate dehydrogenaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 1.4.1.16 - diaminopimelate dehydrogenase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
(3S)-3-amino-4-{[(1S)-1-carboxy-2-phenylethyl]amino}-4-oxobutanoic acid
2% inhibition at 3 mM
(5R)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid
compound identified by molecular dynamics simulation, the predicted binding free energy of the compound with the enzyme is -19.77 kcal/mol, compared to -34.70 kcal/mol for diaminopimelate
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2-[(3S,4S)-3-carboxy-4-propylpyrrolidin-1-yl]-6-methylpyridine-3-carboxylic acid
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3-([3-[(4-methoxybenzene-1-sulfonyl)amino]quinoxalin-2-yl]amino)benzoic acid
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3-([4-[(3,4-dimethylbenzene-1-sulfonyl)amino]-1-hydroxynaphthalen-2-yl]sulfanyl)propanoic acid
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4-oxo-4-[4-[(quinoxalin-2-yl)sulfamoyl]anilino]butanoic acid
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5-[(3-carboxyphenyl)sulfamoyl]-2-hydroxybenzoic acid
6% inhibition at 3 mM
N-[3-[(benzenesulfonyl)amino]phenyl]-3,5-dimethyl-1H-pyrazole-4-sulfonamide
17% inhibition at 3 mM
(2E,6S)-6-aminohept-2-enedioic acid
compound identified by molecular dynamics simulation, the predicted binding free energy of the compound with the enzyme is -29.86 kcal/mol, compared to -34.70 kcal/mol for diaminopimelate
(2S)-2-amino-6-methylideneheptanedioic acid
compound identified by molecular dynamics simulation, the predicted binding free energy of the compound with the enzyme is -31.38 kcal/mol, compared to -34.70 kcal/mol for diaminopimelate
(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid
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(2S,5S)-2-amino-3(3-carboxy-2-isoxazolin-5-yl)propanoic acid
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competitive inhibition
(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid
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(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid
compound is selectively potent to Porphyromonas gingivalis strains W83 and ATCC 33277 with minimum inhibitory concentration values of 773 microM and 1.875 mM, respectively
(5S)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid
compound identified by molecular dynamics simulation, the predicted binding free energy of the compound with the enzyme is -18.89 kcal/mol, compared to -34.70 kcal/mol for diaminopimelate
additional information
diastereomer (5R)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid has no inhibitory activity at pH 7.8
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additional information
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diastereomer (5R)-5-[(2S)-2-amino-2-carboxyethyl]-4,5-dihydro-1,2-oxazole-3-carboxylic acid has no inhibitory activity at pH 7.8
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additional information
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no inhibition by Zn2+, Co2+ and Ni2+ at 1 mM, and by 1 mM of D-lysine, L-lysine, EDTA, 2,2'-dipyridyl, NaN3, or iodoacetic acid
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additional information
no inhibition by EDTA, NaN3, Na2S and iodoacetate at 1 mM
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additional information
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no inhibition by EDTA, NaN3, Na2S and iodoacetate at 1 mM
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