1.4.1.15: lysine dehydrogenase

This is an abbreviated version!
For detailed information about lysine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.15

Reaction

L-lysine
+
NAD+
=
1,2-Didehydropiperidine-2-carboxylate
+
NH3
+
NADH
+
H+

Synonyms

L-lysine epsilon dehydrogenase, LysDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.15 lysine dehydrogenase

Natural Substrates Products

Natural Substrates Products on EC 1.4.1.15 - lysine dehydrogenase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-lysine + NAD+
1,2-didehydropiperidine-2-carboxylate + NH3 + NADH
show the reaction diagram
-
-
-
?
L-lysine + NAD+
1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+
show the reaction diagram
-
-
-
-
r
L-lysine + NAD+ + H2O
1,2-didehydropiperidine-6-carboxylate + NH3 + NADH
show the reaction diagram
-
epsilon amino group is oxidatively deaminated to alpha-aminoadipate delta-semialdehyde, which is spontaneously converted into 1,2-didehydropiperidine-6-carboxylate, first step of lysine degradation
-
?