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1.4.1.12: 2,4-diaminopentanoate dehydrogenase

This is an abbreviated version!
For detailed information about 2,4-diaminopentanoate dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.12

Reaction

(2R,4S)-2,4-diaminopentanoate
+
H2O
 +
NAD(P)+
=
(2R)-2-amino-4-oxopentanoate
 +
NH3
 +
NAD(P)H
 +
H+

Synonyms

2,4-DAPDH, 2,4-diaminopentanoic acid C4 dehydrogenase, 2R,4S-2,4-diaminopentanoate dehydrogenase, DAPDH

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.12 2,4-diaminopentanoate dehydrogenase

Inhibitors

Inhibitors on EC 1.4.1.12 - 2,4-diaminopentanoate dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,4S)-2,4-diaminopentanoate
-
uncompetitive substrate inhibition
2-amino-4-ketopentanoate
-
70% inhibition in the presence of 1 mM 2-amino-4-ketopentanoate
5,5'-dithiobis(2-nitrobenzoate)
-
-
acetyl-CoA
-
30% inhibition in the presence of 1 mM acetyl-CoA
Ca2+
-
85% residual activity at 0.5 mM
Co2+
-
34% residual activity at 0.5 mM
Cu2+
-
complete inhibition at 0.5 mM
D-alanine
-
45% inhibition in the presence of 1 mM D-alanine
D-ornithine
-
uncompetitive inhibition
Fe2+
-
84% residual activity at 0.5 mM
Mg2+
-
65% residual activity at 0.5 mM
N-ethylmaleimide
-
-
Ni2+
-
2% residual activity at 0.5 mM
organic mercurials
-
-
-
p-chloromercuribenzoate
-
-
Zn2+
-
2% residual activity at 0.5 mM
additional information
-
not inhibited by EDTA, KBr, KCl, KNO3, CH3COOK, and K2SO4
-