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1.4.1.1: alanine dehydrogenase

This is an abbreviated version!
For detailed information about alanine dehydrogenase, go to the full flat file.

Word Map on EC 1.4.1.1

Reaction

L-alanine
+
H2O
 +
NAD+
=
pyruvate
 +
NH3
 +
NADH
 +
H+

Synonyms

(S)alanine dehydrogenase, (S)alanine:NAD oxidoreductase, 40 kDa antigen, ADH, AF1665, ALADH, alanine dehydrogenase, alanine oxidative deaminase, alanine oxidoreductase, ALD, AldA, alpha-alanine dehydrogenase, ApalaDH, AsAlaDH, CQA66_00465, dehydrogenase, alanine, glyoxylate reductive aminase, GxrA, HAADH1, HAADH2, L-Ala dehydrogenase, L-AlaDH, L-AlaDH-Bs, L-alanine dehydrogenase, MtbALD, NAD(H)-dependent L-alanine dehydrogenase, NAD+ dependent amino acid dehydrogenase, NAD+-dependent alanine dehydrogenase, NAD-dependent alanine dehydrogenase, NAD-linked alanine dehydrogenase, NADH-dependent alanine dehydrogenase, OF4Ald, PlaAlaDH, PvRA, pyruvate reductive aminase, Rv2780, ScALD, SCO1773, SheAlaDH, TB43

ECTree

     1 Oxidoreductases
         1.4 Acting on the CH-NH2 group of donors
             1.4.1 With NAD+ or NADP+ as acceptor
                1.4.1.1 alanine dehydrogenase

KM Value

KM Value on EC 1.4.1.1 - alanine dehydrogenase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
11
2-oxo-3-methylbutanoate
-
-
2.4 - 23
2-oxobutanoate
0.48
2-oxobutyrate
-
pH 8.5, 82°C
7
2-Oxohexanoate
-
-
23 - 33
2-oxopentanoate
1.61
3-Fluoropyruvate
-
-
80
3-hydroxypyruvate
-
-
12
3-methyl-2-oxobutanoate
-
-
45
4-methyl-2-oxopentanoate
-
-
16
glyoxalate
-
-
1.91 - 12
glyoxylate
2.5
Hydroxypyruvate
-
-
0.33 - 176
L-2-aminobutanoate
0.085
L-2-aminobutyrate
-
pH 8.5, 82°C
0.018 - 30
L-Ala
0.049 - 53
L-alanine
250
L-Ile
-
-
0.014 - 62
L-norvaline
0.039 - 57
L-Ser
24
L-serine
wild-type, pH 10.2, temperature not specified in the publication
0.02 - 150
L-Val
0.01 - 11.4
NAD+
0.009 - 50
NADH
0.35 - 4
NADP+
0.032 - 0.448
NADPH
2.3 - 2900
NH3
0.82 - 500
NH4+
0.97 - 3
oxaloacetate
0.0512 - 8.16
pyruvate
additional information
additional information
-