1.3.99.4: 3-oxosteroid 1-dehydrogenase

This is an abbreviated version!
For detailed information about 3-oxosteroid 1-dehydrogenase, go to the full flat file.

Word Map on EC 1.3.99.4

Reaction

a 3-oxosteroid
+
acceptor
=
a 3-oxo-DELTA1-steroid
+
reduced acceptor

Synonyms

1-ene-dehydrogenase, 3-keto-5alpha-steroid DELTA(1)-dehydrogenase, 3-ketosteroid 1(2)-dehydrogenase, 3-ketosteroid delta1-dehydrogenase, 3-ketosteroid-1-en-dehydrogenase, 3-ketosteroid-D1-dehydrogenase, 3-ketosteroid-DELTA1-dehydrogenase, 3-oxosteroid D1-dehydrogenase, 3-oxosteroid Delta1-dehydrogenase, 3-oxosteroid:(2,6-dichlorphenolindophenol) DELTA1-oxidoreductase, 3-oxosteroid:(2,6-dichlorphenolindophenol)D1-oxidoreductase, 4-en-3-oxosteroid:(acceptor)-1-en-oxido-reductase, 4-ene-3-oxosteroid: (acceptor)-1-ene-oxoreductase, 4-ene-3-oxosteroid:(acceptor)l-ene-oxidoreductase, D1-dehydrogenase, D1-steroid reductase, dehydrogenase, 3-oxo steroid Delta 1-, Delta1-dehydrogenase, DELTA1-KSTD1, DELTA1-steroid reductase, ketosteroid DELTA1-dehydrogenase, KsdD, KsdD1, KsdD2, KsdDM, KSDH, KstD, KSTD1, KSTD2, KSTD3, KSTD3 orthologue, KstDF, Rv3537, steroid-1-dehydrogenase

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.4 3-oxosteroid 1-dehydrogenase

Substrates Products

Substrates Products on EC 1.3.99.4 - 3-oxosteroid 1-dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5alpha,17beta)-17-hydroxyandrostan-3-one + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
11-deoxy-17alpha-hydroxycorticosterone + acceptor
17,21-dihydroxypregna-1,4-diene-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-17alpha,21-diol-3,20-dione
-
-
?
11alpha-hydroxy-testosterone + acceptor
11alpha,17beta-dihydroxyandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
?
11alpha-hydroxyprogesterone + acceptor
11alpha-hydroxy-1,4-pregnene-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-11alpha-ol-3,20-dione
-
-
?
11beta-cortisol + 2,6-dichlorophenol-indophenol
(11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
11beta-hydroxy-4-androstene-3,17-dione + acceptor
11beta-hydroxy-1,4-androstene-3,17-dione + reduced acceptor
show the reaction diagram
11beta-hydroxytestosterone + acceptor
11beta,17beta-dihydroxyandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
-
4-androstene-11beta,17beta-diol-3-one
-
-
?
17alpha-hydroxy-progesterone + acceptor
1,4-pregnene-17alpha-ol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-17alpha-ol-3,20-dione
-
-
?
17alpha-methyltestosterone + acceptor
17alpha-methylandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
?
19-nor-4-androstene-3,17-dione + acceptor
19-nor-1,4-androstene-3,17-dione + reduced acceptor
show the reaction diagram
-
4-estren-3,17-dione
-
-
?
19-nortestosterone + acceptor
17beta-hydroxy-1,4-estrene-3-one + reduced acceptor
show the reaction diagram
-
4-estren-17beta-ol-3-one
-
-
?
19alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
19alpha-hydroxy-androst-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
23,24-bis-nor-5alpha-cholestan-3-one acid + 2,6-dichlorophenol-indophenol
?
show the reaction diagram
3-oxo-5beta-cholan-24-oic acid + acceptor
? + reduced acceptor
show the reaction diagram
-
-
-
-
?
3-oxosteroid + acceptor
3-oxo-DELTA1-steroid + reduced acceptor
show the reaction diagram
-
key catalyst in microbial steroid metabolism
-
-
-
4-androstene-17beta-ol-3-one + 2,6-dichlorophenol-indophenol
1,4-androstadiene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-androstene-3,11,17-trione + acceptor
1,4-androstene-3,11,17-trione + reduced acceptor
show the reaction diagram
-
-
-
-
?
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
1,4-androstadiene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
1,4-androstene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-androstene-3,17-dione + acceptor
1,4-androstadiene-3,17-dione + reduced acceptor
show the reaction diagram
4-androstene-3,17-dione + acceptor
1,4-androstene-3,17-dione + reduced acceptor
show the reaction diagram
4-androstene-3,17-dione + FAD
1,4-androstadiene-3,17-dione + FADH2
show the reaction diagram
4-androstene-3,17-dione + phenazine methosulfate
1,4-androstene-3,17-dione + reduced phenazine methosulfate
show the reaction diagram
-
-
-
-
?
4-pregnen-3-one-20beta-carboxylic acid + 2,6-dichlorophenol-indophenol
pregna-1,4-dien-3-one-20beta-carboxylic acid + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
4-pregnene-3,20-dione + acceptor
1,4-pregnene-3,20 dione + reduced acceptor
show the reaction diagram
5alpha-androst-1-en-3-one + acceptor
5alpha-androstan-3-one + reduced acceptor
show the reaction diagram
-
-
-
-
?
5alpha-androstan-3-one-17beta-ol + 2,6-dichlorophenol-indophenol
(5alpha,17beta)-17-hydroxyandrost-1-en-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5alpha-androstane-17beta-ol-3-one + 2,6-dichlorophenol-indophenol
5alpha-androst-1-ene-17beta-ol-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5alpha-androstane-3,17-dione + 2,6-dichlorophenol-indophenol
5beta-androst-1-en-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5alpha-pregnane-3,20-dione + 2,6-dichlorophenol-indophenol
5alpha-pregn-1-en-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
5beta-androstan-3,17-dione + acceptor
5beta-androst-1-en-3,17-dione + reduced acceptor
show the reaction diagram
-
-
-
-
?
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxy-1,4-androstadiene 3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxy-androst-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + 2,6-dichlorophenol-indophenol
9alpha-hydroxyandrost-1,4-diene-3,17-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + acceptor
9alpha-hydroxy-1,4-androstadiene 3,17-dione + reduced acceptor
show the reaction diagram
9alpha-hydroxy-4-androstene-3,17-dione + FAD
9alpha-hydroxy-1,4-androstadiene-3,17-dione + FADH2
show the reaction diagram
androsterone + acceptor
3-alpha-hydroxy-1-androstene-17-one + reduced acceptor
show the reaction diagram
-
4-androstene-3,11,17-trione
-
-
?
cholesterol + acceptor
?
show the reaction diagram
corticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnene-17alpha,21-diol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
?
corticosterone + acceptor
1,4-pregnene-17alpha,21-diol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-11beta,21-diol-3,20-dione
-
-
?
cortisol + acceptor
prednisolone + reduced acceptor
show the reaction diagram
-
optimal concentration is 0.1 mg/ml, increase of concentration to 1 mg/ml reduces prednisolone yield
-
-
?
cortisone + acceptor
1,4-pregnene-17alpha,21-diol-3,11,20-trione + reduced acceptor
show the reaction diagram
deoxycorticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnadiene-21-ol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
?
deoxycorticosterone + 2,6-dichlorophenol-indophenol
1,4-pregnene-21-ol-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
deoxycorticosterone + acceptor
1,4-pregnene-21-ol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-21-ol-3,20-dione
-
-
?
hydrocorticosterone + acceptor
1,4-pregnene-11beta,17alpha,21-triol-3,20-dione + reduced acceptor
show the reaction diagram
-
4-pregnene-11beta,17alpha,21triol-3,20-dione
-
-
?
progesterone + 2,6-dichlorophenol-indophenol
pregna-1,4-diene + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
progesterone + 2,6-dichlorophenol-indophenol
pregna-1,4-diene-3,20-dione + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
testololactone + acceptor
D-homo-17alpha-oxoandrosta-1,4-diene-3,17-one + reduced acceptor
show the reaction diagram
-
D-homo-17a-oxoandrost-4-ene-3,17-dione
-
-
?
testosterone + 2,6-dichlorophenol-indophenol
17beta-hydroxyandrost-1,4-diene-3-one + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
-
-
-
?
testosterone + 2,6-dichlorophenol-indophenol
? + reduced 2,6-dichlorophenol-indophenol
show the reaction diagram
testosterone + acceptor
17beta-hydroxyandrost-1,4-diene-3-one + reduced acceptor
show the reaction diagram
additional information
?
-