1.3.99.36: cypemycin cysteine dehydrogenase (decarboxylating)

This is an abbreviated version!
For detailed information about cypemycin cysteine dehydrogenase (decarboxylating), go to the full flat file.

Reaction

cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys
+
acceptor
=
C3.19,S21-cyclocypemycin(1-18)-L-Ala-L-Leu-N-thioethenyl-L-valinamide
+
CO2
+
H2S
+
reduced acceptor

Synonyms

CYPD, cypemycin decarboxylase, cypemycin dehydratase.

ECTree

     1 Oxidoreductases
         1.3 Acting on the CH-CH group of donors
             1.3.99 With unknown physiological acceptors
                1.3.99.36 cypemycin cysteine dehydrogenase (decarboxylating)

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Systematic Name

Systematic Name on EC 1.3.99.36 - cypemycin cysteine dehydrogenase (decarboxylating)

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SYSTEMATIC NAME
IUBMB Comments
cypemycin(1-18)-L-Cys-L-Leu-L-Val-L-Cys:acceptor oxidoreductase (decarboxylating, cyclizing)
Cypemycin, isolated from the bacterium Streptomyces sp. OH-4156, is a peptide antibiotic, member of the linaridins, a class of posttranslationally modified ribosomally synthesized peptides. The enzyme decarboxylates and reduces the C-terminal L-cysteine residue, producing a reactive ethenethiol group that reacts with a dethiolated cysteine upstream to form an aminovinyl-methyl-cysteine loop that is important for the antibiotic activity of the mature peptide.