1.3.99.33: urocanate reductase
This is an abbreviated version!
For detailed information about urocanate reductase, go to the full flat file.
Reaction
Synonyms
SO_4620, urdA
ECTree
1.3.99.33 urocanate reductaseAdvanced search results
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General Information on EC 1.3.99.33 - urocanate reductase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
metabolism
enzyme UrdA provides an alternative pathway to metabolize the amino acid histidine by unidirectional reduction of urocanate to imidazole propionate
additional information
ligand-binding domains of UrdA, structure-function analysis, and mechanism of action of UrdA, overview. Both full-length UrdA and two-domain construct UrdA' show specific activity toward urocanate but not to fumarate, suggesting that the functional integrity and substrate specificity are conserved in the two-domain construct. Specific residues, in combination with larger conformational changes, regulate substrate access, and product release. Residue Tyr373 contributes to substrate specificity; residues R560 D388 and R411 are important for catalysis. A large conformational change is observed upon ligand binding
