126.96.36.199: coproporphyrinogen dehydrogenase
This is an abbreviated version!
For detailed information about coproporphyrinogen dehydrogenase, go to the full flat file.
Word Map on EC 188.8.131.52 Reaction
Coproporphyrinogen III +
protoporphyrinogen IX Synonyms
anaerobic coproporphyrinogen III oxidase, At5g63290, AtHEMN1, BtrN, Coprogen oxidase, coproporphyrinogen III oxidase, coproporphyrinogen oxidase, coproporphyrinogenase, CPO, HemN, HEMN1, HemW, More, oxidase, coproporphyrinogen, oxygen-independent coproporphyrinogen III oxidase, oxygen-independent coproporphyrinogen-III oxidase, oxygen-independent CPO, radical S-adenosyl-L-methionine dehydrogenase, radical SAM enzyme, Sll1876, Sll1917, viperin
Inhibitors on EC 184.108.40.206 - coproporphyrinogen dehydrogenase
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uncompetitive substrate inhibition
enzyme inactivation at 30%
O2 affects tetrapyrrole biosynthesis presumably at the level of the S-adenosyl-L-methionine and [4Fe-4S] containing HemN enzyme
not inhibited by S-adenosyl-L-methionine
Cu2+ affects tetrapyrrole biosynthesis presumably at the level of the S-adenosyl-L-methionine and [4Fe-4S] containing HemN enzyme, copper targets the 4Fe-4S clusters in the anaerobic enzyme
copper affects tetrapyrrole biosynthesis presumably at the level of the SAM and [4Fe-4S] containing HemN enzyme. Members of the radical SAM enzyme family are copper sensitive. The excess copper target in the tetrapyrrole pathway is the anaerobic coproporphyrinogen III oxidase [4Fe-4S] containing HemN